COCAINE USE DISORDER
Clinical trials for COCAINE USE DISORDER explained in plain language.
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New pill may blunt Cocaine's high and heart risks
Disease control CompletedThis early-stage study tested whether a drug called STP7 (mavoglurant) can safely reduce the physical and psychological effects of cocaine in people who use it. Twenty-one adults who were experienced with cocaine but not seeking treatment received either STP7 or a placebo, then w…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE1 • Sponsor: Stalicla SA • Aim: Disease control
Last updated May 01, 2026 15:57 UTC
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Could a tiny daily pill curb cocaine cravings in opioid patients?
Disease control CompletedThis study tested whether a low dose of cariprazine (1.5 mg daily) can help people who are already stable on buprenorphine-naloxone for opioid use disorder also reduce or stop cocaine use. About 26 adults with both opioid and cocaine use disorders took either cariprazine or a pla…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: Kyle Kampman • Aim: Disease control
Last updated Apr 29, 2026 15:15 UTC
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Could a diabetes drug help people stay off cocaine?
Disease control CompletedThis study looked at whether pioglitazone, a diabetes medicine, combined with cognitive behavioral therapy can help people who recently stopped using cocaine stay drug-free. 61 adults with cocaine use disorder took part. The goal was to see if the drug improves brain health and r…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE2 • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated Apr 29, 2026 15:14 UTC
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Antibiotic may dull painful memories in PTSD and addiction
Symptom relief CompletedThis study tested whether minocycline, an antibiotic, could reduce the frequency and intensity of intrusive memories in 138 adults with PTSD or cocaine use disorder. Participants took minocycline while recalling their traumatic or drug-related memories, aiming to weaken those mem…
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: Psychiatric University Hospital, Zurich • Aim: Symptom relief
Last updated May 01, 2026 15:57 UTC
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Brain scans could guide cocaine recovery in veterans
Knowledge-focused CompletedThis study looked at brain activity and thinking skills in 63 veterans with cocaine use disorder to see if they could predict who would benefit most from a behavioral treatment called contingency management (CM). CM rewards patients for staying drug-free, but it doesn't work for …
Matched conditions: COCAINE USE DISORDER
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated May 01, 2026 16:00 UTC
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New study checks for Drug-Cocaine interactions in volunteers
Knowledge-focused CompletedThis early-stage study looked at whether the experimental drug SXC-2023 interacts with cocaine in 19 adults who use cocaine but are not seeking treatment. Participants received either the drug or a placebo, then were given intravenous cocaine to monitor safety and effects like he…
Matched conditions: COCAINE USE DISORDER
Phase: PHASE1 • Sponsor: National Institute on Drug Abuse (NIDA) • Aim: Knowledge-focused
Last updated Apr 30, 2026 15:50 UTC