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Thinking ahead may curb cocaine cravings, study suggests

NCT ID NCT05507814

Knowledge-focused Sponsor: Virginia Polytechnic Institute and State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a mental exercise called Episodic Future Thinking (EFT) could change how people with cocaine use disorder make decisions and reduce their cocaine use. 141 participants were asked to vividly imagine positive future events or control events. Researchers measured changes in decision-making, cravings, and brain activity. The goal was to understand if this simple technique could help people think more about long-term rewards over immediate drug use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Episodic Future Thinking (EFT) - a behavioral exercise where participants imagine positive future events
What this could lead to
If it works, this could point toward a simple mental exercise to help people with cocaine use disorder make better decisions and reduce cravings.
What could go wrong
This is a small, early-stage study testing a theory, not a proven treatment. The intervention is brief and may not lead to lasting changes in real-world cocaine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

141 people

The number who actually took part.

Started

Nov 2022

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. demonstrate recent cocaine use and CUD (use in last month, DSM-5 for CUD \> 4) 2. be 18 years of age or older 3. have a desire to quit or cut down on their cocaine use, but do not have proximate plans to enroll in treatment for CUD during the study period Exclusion Criteria: 1. meeting moderate to severe DSM-5 criteria for opioid use disorder 2. having a current diagnosis of any psychotic disorder 3. having a history of seizure disorders or traumatic brain injury 4. having any contraindication for participation in the MRI sessions

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Conditions

The condition(s) this trial relates to.

cocaine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cocaine use disorder

Contacts and locations

Locations

  • Fralin Biomedical Research Institute at VTC

    Roanoke, Virginia, 24016, United States

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Other studies related to the condition(s) this trial covers.