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Could a Two-Drug combo curb cocaine cravings? new study says maybe

NCT ID NCT05262270

Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a combination of two extended-release medications (naltrexone and buprenorphine) could help adults reduce cocaine use. Over 400 people who wanted to cut back or quit cocaine took part. The approach uses monthly injections to manage cravings and use, aiming for better control of the disorder.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

427 people

The number who actually took part.

Started

Apr 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Individuals must meet all of the inclusion criteria and no exclusion criteria in order to be eligible to participate in the study, including but not limited to: Inclusion Criteria: 1. Be 18 to 65 years of age; 2. Be interested in reducing or stopping cocaine use. 3. Be willing to comply with all study procedures and medication instructions. Exclusion Criteria: 1\. Have any condition for which, in the opinion of the site investigator or designee, study participation would not be in their best interest or that could prevent, limit, or confound the protocol-specified assessments.

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Conditions

The condition(s) this trial relates to.

cocaine dependence Cocaine-Related Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cocaine use disorder

Contacts and locations

Locations

  • Addictions Institute of Mount Sinai

    New York, New York, 10029, United States

  • Berman Center for Outcomes and Clinical Research at Hennepin Healthcare

    Minneapolis, Minnesota, 55404, United States

  • Center on Substance Use and Health (CSUH)

    San Francisco, California, 94102, United States

  • Cove Behavioral Health

    Tampa, Florida, 33605, United States

  • Mountain Manor Treatment Center

    Baltimore, Maryland, 21229, United States

  • UCLA Vine Street Clinic

    Los Angeles, California, 90038, United States

  • UTSW Medical Center, Center for Depression Research and Clinical Care

    Dallas, Texas, 75247, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35209, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60608, United States

  • University of Texas Health San Antonio

    San Antonio, Texas, 78229, United States

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