Can a supplement curb cocaine cravings during opioid withdrawal?
NCT ID NCT05610072
First seen Dec 18, 2025 · Last updated May 18, 2026 · Updated 22 times
Summary
This study looked at how the brain chemical glutamate changes in people who use both opioids and cocaine. Researchers tested whether a supplement called N-acetylcysteine (NAC) could reduce cravings for cocaine during opioid withdrawal. Twelve adults with opioid and cocaine use disorder participated, but they were not seeking treatment. The goal was to understand brain function, not to provide a cure.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Kentucky Department of Behavioral Science
Lexington, Kentucky, 40536-0086, United States
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University of Kentucky Laboratory of Human Behavioral Pharmacology
Lexington, Kentucky, 40507, United States
Conditions
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