COCAINE USE DISORDER

This early-stage study is testing whether pentoxifylline, a drug that reduces inflammation, can lower the rewarding effects of cocaine. Thirty adults with cocaine use disorder who are not seeking treatment will take the drug and then choose between cocaine or money in a controlle…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with cocaine use disorder reduce their cocaine use. About 75 adults will receive semaglutide along with counseling. Researchers will measure changes in brain responses to cocaine-relat…

This study tests whether a gentle brain stimulation technique called tDCS can help people with cocaine addiction feel less craving. 120 adults with cocaine use disorder will receive tDCS sessions over 5 weeks while doing cognitive tasks. Researchers will use brain scans to see ho…

This study tests whether clonidine, a blood pressure medicine, can reduce cravings in people hospitalized for cocaine or crack use. 36 participants will receive either clonidine or an active placebo (clonazepam) to compare effects. The goal is to find a safe, effective way to eas…

This study uses a special brain scan (PET) to measure the density of connections between brain cells in people with cocaine use disorder compared to healthy volunteers. Researchers want to understand how cocaine changes the brain's wiring. About 80 adults aged 21-60 will particip…

This study follows 32 people with cocaine use disorder during inpatient detox to see how their sleep changes from active use through early and late withdrawal. Using wearable sleep monitors, questionnaires, and hormone tests, researchers aim to understand both objective and perce…

This study aims to find the best way to use financial incentives to help people with opioid or cocaine use disorder stay drug-free. Researchers will compare two types of reward schedules—one that increases rewards over time and one that decreases them—using a smartphone app. Abou…