Can a blood pressure drug curb cocaine cravings?
NCT ID NCT07313371
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether clonidine, a blood pressure medicine, can help reduce cravings in people hospitalized for cocaine or crack use disorder. 36 participants will receive either clonidine or an active placebo (clonazepam) to compare effects. The main goal is to see if cravings decrease, measured by a simple 0-10 scale.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients hospitalized in the adult Alcohol and Drugs ward of the Perdizes Institute (IPer) at the Hospital das Clínicas, University of São Paulo Medical School * DSM-5 criteria for cocaine and/or crack use disorder * Voluntarily seeking treatment * Must be able to swallow pills Exclusion Criteria: * Inability to read and/or understand the study questionnaires * benzodiazepine use disorder * opioid use disorder * alcohol use disorder
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Instituto Perdizes
RECRUITINGSão Paulo, São Paulo, 05021-001, Brazil
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Other studies related to the condition(s) this trial covers.
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