PET scans reveal Cocaine's impact on brain wiring
NCT ID NCT04721418
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 40 times
Summary
This study uses PET scans with a special tracer to measure the density of synapses (connections between brain cells) in people with cocaine use disorder compared to healthy volunteers. Researchers aim to see if cocaine changes brain connections, especially in areas linked to decision-making and reward. The study involves 80 participants and includes a 3-week abstinence period for the cocaine group to track changes over time.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COCAINE USE DISORDER are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Connecticut Mental Health Center
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
11C-UCB-J (radioactive tracer for PET scan)
What this could lead to
If successful, this could reveal how cocaine changes brain connections, pointing toward new treatments for addiction.
What could go wrong
This is an early observational study, not a treatment trial. It may not find clear differences or lead directly to therapies.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.