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Can brain scans predict who quits cocaine? VA study hopes to find out

NCT ID NCT03799341

First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times

Summary

This study looked at how brain signals and thinking skills affect recovery from cocaine addiction in 63 veterans. Participants either received usual care or a prize-based program that rewards cocaine-free urine tests. Researchers measured brain activity and thinking before and during treatment to see what predicts success. The goal is to personalize addiction treatment based on each person's brain function.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

    Pittsburgh, Pennsylvania, 15240, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Prize-Based Contingency Management (a behavioral program where patients earn chances to win prizes for cocaine-free urine tests)

What this could lead to

If successful, this could help doctors choose the best version of contingency management for each veteran, improving recovery from cocaine addiction.

What could go wrong

This is a small, early-stage study (63 participants) that only measures brain signals and behavior. It does not test a new drug or cure, so the direct benefit to patients is limited.

Conditions

The condition(s) this trial relates to.

cocaine dependence Cocaine-Related Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.