Va Office Of Research And Development

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach leads to greater weight loss and PTSD symptom reduction compared to standard VA care. About 182 Veterans will take pa…

This study tests whether giving immunotherapy and chemotherapy before radiation can help veterans with stage III lung cancer that cannot be removed by surgery. About 25 participants will receive the treatment combination. The goal is to see if this approach improves how long the …

This study tests whether adding a drug that blocks a cancer cell survival process (autophagy) to standard TACE treatment can better kill liver cancer cells and boost the immune system. About 93 adults with unresectable liver cancer will receive the combination. The goal is to see…

This study looks at whether adding a smartphone app to standard medication can help Veterans with alcohol use disorder drink less heavily. About 330 Veterans from VA primary care will either get medication alone or medication plus the app. The goal is to see if the app makes it e…

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in veterans aged 55 and older who have obesity and signs of muscle loss (sarcopenia). Participants will be randomly assigned to either the e…

This study looks at whether a type of dietary fiber (soluble corn fiber) can help older men absorb more calcium and improve bone health. Researchers will enroll 30 male Veterans aged 60 and older. Participants will take the fiber supplement and have their calcium absorption, bone…

This study is for veterans with prostate cancer that has returned in a few spots (1-10) after initial treatment. It compares standard hormone therapy alone versus standard therapy plus PET-guided radiation to those spots. The goal is to see if adding radiation delays the cancer f…

This study tests a program called Measurement-Based Care (MBC) for veterans with inflammatory bowel disease (IBD). The program involves regular check-ins between clinic visits to track symptoms and adjust treatment early. Researchers want to see if this approach improves quality …

This study looks at two different talk therapies for Veterans recently hospitalized for suicide risk. 136 Veterans will be randomly assigned to one of the therapies and followed for a year. Researchers will also use brain scans to see if they can predict who might attempt suicide…

This study tests whether a new combination of two oral drugs (Stenoparib and Temozolomide) works better than the current standard treatment for people whose small cell lung cancer has returned after initial therapy. About 166 adults with relapsed extensive-stage small cell lung c…

This study tests a simple, non-invasive technique called remote ischemic preconditioning in 240 adults with heart failure who are scheduled for a heart catheterization. Before the procedure, a blood pressure cuff on the arm is inflated briefly to temporarily restrict blood flow, …

This study tests whether a butyrate supplement (a type of fatty acid) can improve physical function in 120 veterans with Gulf War Illness. The treatment aims to restore gut health, reduce fatigue, and ease cognitive problems. Participants will take the supplement and be monitored…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device monitors sleep and gently vibrates to interrupt nightmares without fully waking the person. Researchers want to see if better sleep from fewer nightmar…

This study tests whether adding itraconazole, a common antifungal medication, to standard chemotherapy and radiation can improve outcomes for people with esophageal cancer. About 78 participants with resectable tumors will receive itraconazole before surgery. The goal is to see i…

This study explores whether brief, mild changes in oxygen levels (called mild intermittent hypoxia) can improve blood vessel function and reduce tiredness in people with obstructive sleep apnea. The treatment aims to help those who struggle with standard CPAP therapy. Researchers…

This study tests whether adding an experimental drug (tulmimetostat) to an existing immunotherapy (pembrolizumab) can shrink tumors or slow cancer growth in people with advanced non-small cell lung cancer whose disease has worsened after initial treatments. About 66 veterans will…

This study tests whether adding an experimental drug (capivasertib) to standard hormone therapy before prostate surgery can better shrink or destroy high-risk prostate cancers that have a specific genetic change (PTEN loss). About 30 men with localized but aggressive prostate can…

This study tests a face-to-face program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The goal is to help them build skills and motivation to successfully take part in home-based cardiac rehab. R…

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have received a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if the drug improves kidney functi…

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One group gets a combination of Dialectical Behavior Therapy (DBT) and a special PTSD therapy (DBT PE), while the other gets standard care. The goal is to see which approach better reduces…

This early-stage trial tests a new drug delivery system for non-muscle-invasive bladder cancer that has not responded to standard BCG therapy. The drug, called PPM, uses tiny particles to deliver chemotherapy directly to cancer cells in the bladder. Up to 29 participants will rec…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study is testing a new treatment strategy for men with advanced prostate cancer that has stopped responding to standard hormone-blocking therapy. All participants will receive two types of targeted radiation treatment and will stop their current hormone-suppressing therapy. …

This study is for Veterans with advanced liver disease who want better care. It uses a nurse counselor over video or phone to help patients understand their illness, share what matters most to them, and align treatments—including possible liver transplant—with their goals. The st…

This study is testing whether the drug empagliflozin, which is used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. The goal is to see if it can help protect the heart and the transplanted kidney. The study will enroll 264 vetera…

This study tests whether the medication empagliflozin can make arteries more flexible in veterans with obesity. About 50 participants will take either the drug or a placebo for 12 weeks. The goal is to see if the drug improves blood vessel health, which could lower future heart r…

This study tests whether a telehealth pain management program can help veterans who have surgery outside the VA avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery through community care will either receive the telehealth program or standard care. …

This study compares two screening methods—ultrasound and a shorter MRI—to see which finds liver cancer earlier in people with cirrhosis. The goal is to catch cancer at a stage where it can be treated more effectively, potentially reducing deaths from liver cancer. About 4,700 par…

This study tests whether a smart mat that checks foot temperature at home can help prevent foot ulcers in 800 Veterans with diabetes who have had a foot ulcer or amputation before. The mat sends data to a monitoring team that alerts VA providers if problems arise. The goal is to …

This study tests whether a program called VA Brief Intervention and Contact (VA BIC) can lower suicide risk in Veterans after they leave a non-VA mental health treatment center. About 120 Veterans who have had recent suicidal thoughts will take part. The goal is to see if this ap…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via video calls at home, can improve social and daily functioning in veterans recently discharged from the hospital for heart problems. About 132 veterans with depression will receive either 1…

This study is testing a wearable leg exoskeleton to help people with spasticity (muscle stiffness) from spinal cord injury. Ten veterans will use the device for leg stretching, treadmill walking, and overground walking to see if it improves muscle activity, joint motion, and walk…

This study compares a new type of below-knee amputation (called Ewing amputation) to the standard procedure in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the t…

This study tests a 3-session program called Omnis Salutis that teaches veterans how to communicate their health goals to doctors and loved ones. It includes 238 veterans with PTSD, depression, anxiety, or substance use issues. The goal is to see if the program improves their soci…

This study tests whether yoga-based exercises can improve community functioning in veterans with severe mental illness like schizophrenia or bipolar disorder. About 112 veterans will be randomly assigned to either yoga or a wellness program. The goal is to see if yoga helps with …

This study compares a new therapy that treats both social anxiety and PTSD at once to standard therapy that focuses on one condition at a time. About 264 veterans will participate. The goal is to see if the new approach works as well or better and is easier for the VA to offer.

This study tests whether a wearable robotic arm device (MyoPro) combined with motor-learning therapy can improve arm function in people who had a stroke at least 6 months ago and have severe arm weakness. About 60 participants will be randomly assigned to receive either therapy w…

This study tests a new way to deliver exercise rehab to people with Parkinson's disease using a stationary bike that can be monitored and adjusted remotely. Researchers will enroll 72 veterans to see if this approach improves movement and thinking. The goal is to provide effectiv…

This early-phase study tests whether a non-invasive magnetic pulse treatment, called iTBS, can safely reduce impulsivity and suicidal thoughts in veterans who have had a mild traumatic brain injury. About 55 veterans will receive the treatment daily for two weeks. The goal is to …

This study tests a home-based telerehabilitation program for 40 veterans who recently finished treatment for early-stage lung cancer. The program aims to reduce common after-treatment problems like shortness of breath, fatigue, and fear of cancer returning, while improving physic…

This study tests whether a home-based exercise program using a wearable activity monitor and group coaching can improve walking ability in Veterans with peripheral artery disease (PAD). PAD causes leg pain and limits walking, but supervised exercise is often inconvenient. The pro…

This study tests whether a device that reads muscle signals can help stroke survivors with severe arm weakness improve their arm movement during early rehabilitation. Ten veterans who had a stroke within the past 2 days to 6 months will use the device alongside standard therapy. …

This study tests a mobile app called MIST designed to help veterans reduce suicidal thoughts. The app uses techniques to change unhelpful thinking patterns. Researchers will enroll 50 veterans to see if the app is easy to use and acceptable as a support tool alongside regular men…

This study looks at whether a special intermittent fasting diet can help people with advanced lung cancer who are receiving immunotherapy. Researchers want to see if the diet is safe and if it can make the cancer treatment work better. About 66 patients will take part, following …

This study compares two approaches for veterans with mental health and relationship problems: a 3-session couple-based program (Brief Relationship Checkup) versus standard individual care. The goal is to see which better reduces suicide risk factors by improving relationship heal…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury (SCI) manage chronic pain. Ten veterans will try a specially adapted version of the VA CALM mindfulness course, first in a group and later using VR headsets. The goal …

This study is testing whether using a weighted blanket at night can help veterans with chronic pain and sleep problems. Researchers will give 160 veterans either a light (3-pound) or heavy (15-pound) blanket to use at home for 6 weeks. They will track changes in pain levels, slee…

This study looks at whether adding aerobic exercise (like walking or cycling) to standard physical therapy can help stroke survivors recover better. Researchers want to see if it improves arm movement, thinking, and mood. The study involves 40 Veterans who had a stroke at least 6…

This study tests a non-invasive device that stimulates the vagus nerve to help veterans with alcohol use disorder. The goal is to reduce withdrawal-related distress, cravings, and improve quality of life. Eighty veterans will receive the stimulation and be monitored for changes i…

This study tests a new, non-invasive brain stimulation technique called LIP-tES to help reduce light sensitivity in Veterans who have had a mild traumatic brain injury. About 36 participants will receive either real or sham stimulation and complete questionnaires and MRI scans to…

This study is testing whether a lightweight, wearable exoskeleton can help people with Parkinson's disease walk more safely and with fewer falls. Thirty veterans with mild to moderate Parkinson's will use the device during supervised walking sessions twice a week for eight weeks.…

This study tests whether hearing aids can improve daily life for veterans who have normal hearing tests but still struggle to understand conversations, especially in noisy places. About 142 veterans will either get hearing aids or standard care, and researchers will measure chang…

This study looks at two different exercise routines for veterans with moderate Parkinson's disease. One group will exercise a lot for one week, then rest for three weeks. The other group will exercise every week without breaks. Researchers will measure walking speed, overall phys…

This study tests a 40-minute web-based program designed to teach Veterans coping skills for suicidal thoughts. Researchers will compare the program to standard care in 180 Veterans over one month. The goal is to see if the online tool reduces suicidal thoughts and behaviors more …

This study looks at whether walking on an incline or walking faster on flat ground is better for people with COPD to reduce shortness of breath during exercise. About 54 veterans with COPD will walk on a treadmill in different ways to see which approach helps them breathe easier …

This study tests whether wearing bright light therapy glasses can reduce leftover daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who already use CPAP. About 60 participants will wear active or sham light glasses for four weeks each, in random or…

This study tests four different programs to help cancer survivors who have been using opioids for a long time reduce their opioid use and better manage chronic pain. About 294 veterans who have finished cancer treatment and still have pain will try one of these programs. The goal…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea. About 668 participants will use PAP therapy and be tested on memor…

This study tests whether a 3-month virtual nutrition program, including food delivery and cooking demonstrations, can help older veterans with limited mobility eat better and feel more connected. Researchers will measure diet quality, social engagement, and quality of life in 180…

This study tests a home-based program for older veterans (age 60+) with multiple chronic conditions and limited mobility. The program combines high-intensity exercise, self-management training, social support, and telehealth technology. Researchers want to see if it improves stre…

This study tests whether allopurinol, a medicine usually used for gout, can improve heart function, exercise ability, and quality of life in African American veterans with resistant high blood pressure. About 50 participants will take allopurinol for 8 weeks. The goal is to see i…

This study tests whether a gentle brain stimulation technique called tDCS can boost the effects of cognitive training to help veterans with obesity become less impulsive and lose weight. About 124 veterans will be randomly assigned to receive either real or fake tDCS during cogni…

This study tests a sleep therapy adapted for trauma survivors in women veterans with both insomnia and PTSD. Half receive the sleep therapy, half get a standard educational program. The goal is to see if better sleep makes them more willing and able to start PTSD treatment. 100 w…

This study tests a home-based virtual reality program to help veterans with traumatic brain injury who have trouble focusing on close objects. About 45 veterans will use VR games to improve their near vision. The goal is to make diagnosis and treatment easier and more accessible.

This study compares two ways of delivering prolonged exposure therapy for PTSD in veterans: standard therapy versus therapy with a companion smartphone app called PE Coach. About 124 veterans with PTSD will be randomly assigned to one of the two groups. Researchers want to see if…

This study tests whether adding a memory-enhancing technique to standard PTSD therapy (cognitive processing therapy) helps older veterans learn and remember therapy content better. About 30 veterans over age 59 with PTSD will participate. The goal is to see if this approach is fe…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. Fatigue is a common and disabling symptom after stroke. The study will measure changes in fatigue, mood, and thinking b…

This study tests whether a specific type of sound therapy, called notched noise therapy, can help reduce the ringing in the ears (tinnitus) that many Veterans experience. About 108 Veterans with constant tinnitus will use special ear-level devices that play sounds designed to cal…

This study looks at whether oxygen, finasteride, or acetazolamide can help reduce sleep apnea in adults aged 60 and older with mild to moderate sleep apnea. The goal is to find new ways to stabilize breathing and improve sleep quality. Researchers will measure breathing patterns …

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with moderate to severe anxiety and depression. The medication is already known to be safe and well-tolerated. Researchers hope it may also help with sleep problems and chroni…

This study tests a new bandage called exciflex that delivers small amounts of electricity to help heal chronic wounds that won't close on their own. The study includes 16 veterans with diabetes or spinal cord injury who have wounds on their lower legs. The bandage can stay on for…

This study tests whether dronabinol, a drug similar to a compound in marijuana, can help people with obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep tests before and after will measure if breathing problems during sl…

This study is testing a new social skills training program for Veterans with serious mental illnesses like schizophrenia, bipolar disorder, major depression, or PTSD. The program is designed to help them better understand social cues and build stronger relationships at work. Abou…

This study looks at whether a combination of flywheel resistance and aerobic exercise can reduce fatigue and improve muscle function in veterans with chronic kidney disease (stages 3 and 4) who are not yet on dialysis. About 30 participants will undergo exercise training, and res…

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study tests whether a 6-month online spin cycling program can improve vision and daily function in 70 veterans aged 65-89 with intermediate age-related macular degeneration (AMD). AMD is a leading cause of vision loss, and there are few treatments. Participants will join gro…

This study tests a simple, 3-session writing program to help sexual minority veterans cope with stress related to their identity. Researchers want to see if it's practical and can reduce symptoms of depression and anxiety. About 85 veterans who identify as gay, lesbian, bisexual,…

This study tests two approaches to help people with knee osteoarthritis keep up with physical therapy exercises at home. One uses a smartphone app with game-like rewards and social support, and the other adds a health coach. The goal is to see if these methods improve long-term p…

This study tests a home-based, supervised group exercise program for veterans who had COVID-19 at least 90 days ago. The goal is to see if this tele-rehabilitation program can improve their heart and lung fitness. The study will enroll 80 high-risk veterans with conditions like h…

This study tests whether daily growth hormone injections for 6 months can improve quality of life in veterans who have both mild traumatic brain injury (mTBI) and adult growth hormone deficiency (AGHD). About 172 veterans aged 21-55 will receive either the hormone or a placebo. T…

This study tests a non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can safely improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, and …

This study tests whether giving a personal hearing amplifier to Veterans who have trouble hearing in the emergency room can help them understand their discharge instructions better and reduce the chance of returning to the ER within 3 or 30 days. About 1,050 Veterans from six VA …

This study tests whether high intensity interval training (HIIT) can reduce frailty and improve resilience in 200 older veterans aged 65 and up. Participants will do supervised bike exercises at a center and at home. The goal is to improve physical fitness, thinking skills, and t…

This study tests whether adding a cream called imipramine (an antidepressant) to standard light therapy (PDT) can improve treatment of actinic keratosis, a common skin pre-cancer, in 48 U.S. veterans. The goal is to see if imipramine reduces immune system suppression caused by PD…

This study tests whether metformin, a safe diabetes drug, can improve walking ability and reduce leg pain in veterans with peripheral artery disease (PAD). PAD causes leg pain during activity due to blocked arteries, and there is no effective medical treatment. The trial will giv…

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can help veterans with obsessive-compulsive disorder (OCD) function better at work, home, and in social settings. About 160 veterans with OCD (half also have PTSD) will receive either ER…

This study tests whether a small, FDA-cleared device placed on the ear can reduce pain and improve daily function in 240 veterans with fibromyalgia. The device sends mild electrical pulses to nerves in the ear, aiming to calm pain signals without medication. Participants will be …

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD and struggle to recognize emotions in others. The program combines face and voice emotion training with attention exercises. Researchers hope this will improve veterans'…

This study looks at whether adding Whole Health Coaching to standard pain management helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans who have high-impact chronic pain and take long-term opioids will take part. The goal is to see if coa…

This study looks at whether a supervised exercise program can improve balance and walking in older adults with moderate (50-69%) narrowing of the carotid artery who have no symptoms. About 50 participants will do aerobic and balance exercises. The goal is to see if exercise helps…

This study tests whether a brief PTSD therapy called Written Exposure Therapy (WET) works for veterans who also have a serious mental illness like schizophrenia or bipolar disorder. The goal is to see if the therapy is practical and helpful for this group, and to make it more cul…

This study tests a two-session program for family members of Veterans with PTSD. The goal is to see if involving family helps Veterans stay in their regular PTSD therapy and reduces symptoms more than therapy alone. About 200 Veteran-family pairs will take part, with some familie…

This study tests a cognitive behavioral therapy (CBT) program that treats anxiety, PTSD, and alcohol use at the same time in veterans. The goal is to improve how well participants function in daily life, reduce anxiety, and lessen alcohol-related problems. The study will enroll 4…

This study is for people with spinal cord injury who have trouble emptying their bowels. Normally, they use a gloved finger to stretch the rectum to help things move. The researchers want to see if using a mild electrical zap instead works just as well or better. If it does, it c…

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes basic sensory information, which may help thinking, daily f…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, mood, and sleep in veterans who have both mild traumatic brain injury and PTSD. About 144 veterans from two VA hospitals will take part. The goal is to find better ways to …

This study tests whether a group exercise program done over video calls is practical and helpful for veterans with knee or hip arthritis. Fifty veterans will take part in a 3-month exercise program, followed by 6 months of maintenance with either text messages or extra group sess…

This study is testing a new wheelchair design that lets users change gears, similar to a bicycle. The goal is to see if having different gear ratios makes pushing easier on flat ground, uphill, or over carpet, and reduces shoulder pain. About 30 manual wheelchair users with spina…

This study compares two support programs for family caregivers of Veterans with dementia who are in the hospital. One program, Hospital GamePlan4Care, provides a handbook, online training, and phone coaching tailored to the caregiver. The other offers general education and resour…

This study is testing whether a single intravenous dose of ketamine can quickly improve depression in 80 veterans with Parkinson's disease who haven't responded well to standard antidepressants. Researchers will also look at how ketamine affects the brain's ability to adapt and l…

This study looks at whether older adults (75+) who had precancerous polyps removed still benefit from repeat colonoscopies. Researchers will track cancer rates in 130,000 Veterans and interview patients and doctors to understand risks and benefits. The goal is to create clear gui…

This study looks at why people with Parkinson's disease have trouble with balance and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes to understand the brain pathways involved. The goal is to gather information that could l…

This study uses a special X-ray technique to see how the bone and skin move inside a prosthetic leg socket when people walk. Researchers want to compare two types of socket suspension to find which one reduces movement and improves comfort. About 21 adults with a below-knee amput…

This study looks at Veterans aged 50-75 who had a moderate traumatic brain injury (TBI) at least 15 years ago. Researchers want to see if these individuals have worse balance and thinking skills compared to those without a TBI, even if they feel fine. The goal is to gather inform…

This study aims to understand what causes substance use and cravings in Veterans with substance use disorder. Researchers will create a personal model for each participant showing links between their substance use, urges, and other symptoms like anxiety or PTSD. They will also te…

This study looks at whether sleep problems, like sleep apnea, make thinking and memory worse after a COVID-19 infection. Researchers will follow 200 veterans to measure sleep, brain function, and quality of life. The goal is to find out if treating sleep issues can help people re…

This study looks at how emotions and brain inflammation are connected to pain in veterans with fibromyalgia, a chronic pain condition. Researchers will measure pain, mood, and inflammation markers in 60 veterans. The goal is to use this information to create an exercise program t…

This study is creating and testing materials to help veterans with mental illness or substance use disorders adjust to life after prison. Researchers will work with 20 veterans who have been out of prison for up to three years. The goal is to improve their mental health and quali…

This study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…

This study looks at why some veterans experience lasting brain and mental health problems after COVID-19, like memory issues and fatigue. Researchers will track 200 veterans over time, using surveys and thinking tests to measure symptoms. They also collect blood and saliva to fin…

This study looks at why central sleep apnea (CSA) occurs in people with heart failure or those taking opioid painkillers. Researchers will test combinations of breathing devices and medications in 200 Veterans to find better ways to treat CSA. The goal is to understand the body's…

This study tests a computer-based brain training program for people who have memory and thinking problems after a stay in the Intensive Care Unit (ICU). About 160 adults who recently left the ICU will be randomly assigned to use the program or receive usual care. The goal is to s…

This study looks at how to help older adults with chronic kidney disease recover muscle strength and function after being in the hospital. Researchers will test different ways to measure muscle health and compare home-based versus supervised exercise programs. The goal is to find…

This study looks at how COVID-19 treatments like Paxlovid and remdesivir are used in the VA healthcare system and how well they work. Researchers will study up to 400,000 veterans to compare treatments, track hospitalizations and deaths, and also examine flu and RSV vaccines and …

This study looks at whether a genetic test can help find men who are at high risk for serious prostate cancer while helping low-risk men avoid unnecessary biopsies. About 5,000 male Veterans aged 55-69 will take part. The goal is to make prostate cancer screening more accurate an…

This study looks at whether a computer-based working memory training program can help veterans with PTSD learn to overcome fear. About 120 veterans will do memory exercises or a sham version for 4 weeks, then have brain scans and fear tests. The goal is to see if the training cha…

This study looks at whether backward walking training can improve walking and balance in people who have had a stroke. Researchers will compare two different training schedules (18 vs. 27 sessions) and use brain scans to see how the brain changes. The goal is to find the best dos…

This study aims to help Veterans and their primary care doctors decide whether an in-person, phone, or video visit is best for each situation. Researchers will survey 600 Veterans and their doctors to understand the benefits and costs of each visit type. They will then test a new…

This study tests a new tool that helps physical therapists create personalized recovery plans for veterans after total knee replacement. Instead of a one-size-fits-all approach, the tool adjusts therapy based on each person's needs and goals. The goal is to improve how well veter…

This study tests a program called VA S.A.V.E. that teaches family members and friends of Veterans how to spot signs of suicide risk and connect the Veteran to professional help. About 710 participants who are close to a Veteran will take the training and report how often they use…