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Can a simple therapy ease OCD in veterans? new trial aims to find out

NCT ID NCT05240924

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About half of the 160 participants also have post-traumatic stress disorder (PTSD). The therapy involves 8-16 sessions where veterans learn to face their fears without performing compulsive rituals. The goal is to see if ERP works better than usual care for this group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exposure and Response Prevention (ERP) therapy
What this could lead to
If successful, this could provide an effective, evidence-based therapy option for veterans with OCD, including those who also have PTSD.
What could go wrong
This is a relatively small trial (160 participants) and the therapy may not work for everyone. It is also limited to veterans in specific VA settings, so results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia. * Willingness to participate in Exposure and Response Prevention(ERP) Exclusion Criteria: * Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use). * Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.

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Conditions

The condition(s) this trial relates to.

Compulsive Behavior obsessive-compulsive disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Comorbid post-traumatic stress disorder and OCD Obsessive compulsive disorder (OCD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    19 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Asheville VA Medical Center, Asheville, NC

    RECRUITING

    Asheville, North Carolina, 28805-2576, United States

  • Durham VA Medical Center, Durham, NC

    RECRUITING

    Durham, North Carolina, 27705-3875, United States

  • East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ

    RECRUITING

    East Orange, New Jersey, 07018, United States

  • Fayetteville VA Medical Center, Fayetteville, NC

    RECRUITING

    Fayetteville, North Carolina, 28301-3856, United States

  • Hampton VA Medical Center, Hampton, VA

    RECRUITING

    Hampton, Virginia, 23667, United States

  • Hunter Holmes McGuire VA Medical Center, Richmond, VA

    RECRUITING

    Richmond, Virginia, 23249-0001, United States

  • James J. Peters VA Medical Center, Bronx, NY

    RECRUITING

    The Bronx, New York, 10468-3904, United States

  • Jonathan M. Wainwright Memorial VA Medical Center, Walla Walla, WA

    RECRUITING

    Walla Walla, Washington, 99362-3975, United States

  • Michael E. DeBakey VA Medical Center, Houston, TX

    RECRUITING

    Houston, Texas, 77030-4211, United States

  • Michael E. DeBakey VA Medical Center, Houston, TX

    RECRUITING

    Houston, Texas, 77030-4211, United States

  • Northport VA Medical Center, Northport, NY

    RECRUITING

    Northport, New York, 11768-2200, United States

  • Ralph H. Johnson VA Medical Center, Charleston, SC

    RECRUITING

    Charleston, South Carolina, 29401-5703, United States

  • Salem VA Medical Center, Salem, VA

    RECRUITING

    Salem, Virginia, 24153-6404, United States

  • Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC

    RECRUITING

    Salisbury, North Carolina, 28144, United States

  • Spokane VA Medical Center, Spokane, WA

    RECRUITING

    Spokane, Washington, 99205-6185, United States

  • VA NY Harbor Healthcare System, New York, NY

    RECRUITING

    New York, New York, 10010-5011, United States

  • VA Roseburg Healthcare System, Roseburg, OR

    RECRUITING

    Roseburg, Oregon, 97471, United States

  • VA Southern Oregon Rehabilitation Center and Clinics, White City, OR

    RECRUITING

    White City, Oregon, 97503, United States

  • VA Western New York Healthcare System, Buffalo, NY

    RECRUITING

    Buffalo, New York, 14215-1129, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.