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Could vitamin d and iron tame OCD's impulse control?

NCT ID NCT07763977

Disease control Sponsor: Guangdong Provincial People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial explores whether adding vitamin D and iron supplements to usual OCD treatment can improve the ability to control impulses. It involves 60 people with OCD who will receive the supplements for 12 weeks. Researchers will use brain scans and behavioral tasks to see if these supplements affect brain chemicals linked to self-control and immune function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
calcitriol (a form of vitamin D) and iron supplements
What this could lead to
If successful, this could point toward a simple supplement-based add-on to help people with OCD better control impulses and reduce symptoms.
What could go wrong
This is a small, early-stage trial with no control group, so results may not be conclusive. Supplements may not affect brain chemistry as hoped, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Meet the DSM-5 diagnostic criteria for obsessive-compulsive disorder (OCD); 2. Have a total score of ≥16 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and a total score of \<17 on the 17-item Hamilton Depression Rating Scale (HAMD-17); 3. Have a disease duration of ≥1 year and be between 14 and 50 years of age; 4. Be right-handed and have completed at least junior high school education; and 5. Fully understand the study procedures, be willing and able to participate in and complete the entire study, and provide written informed consent. Exclusion Criteria: 1. Presence of a neurological disorder or serious medical condition; 2. Pregnancy or breastfeeding; 3. A history of alcohol or substance abuse or dependence; 4. A history of seizures; 5. A diagnosis of a major psychotic disorder or bipolar disorder; 6. A diagnosis of depressive disorder; 7. Any contraindication to magnetic resonance imaging (MRI); 8. Use of iron or vitamin D supplements within the previous 6 months, or use of corticosteroids for any reason within the previous 3 months; or 9. Presence of an acute or chronic systemic disease that may affect iron or vitamin D levels, including, but not limited to, hypothyroidism, hyperthyroidism, hypoparathyroidism, hyperparathyroidism, diabetes mellitus, clinically active infection, or iron-deficiency anemia.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive compulsive disorder (OCD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Guangdong Mental Health Center, Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510120, China

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