Veterans' skin treatment gets a potential boost from an old drug
NCT ID NCT06778434
First seen Jan 10, 2026 · Last updated Jun 22, 2026 · Updated 28 times
Summary
This study tests whether adding a cream containing imipramine (an antidepressant) to standard photodynamic therapy (PDT) can improve treatment of actinic keratosis, a common pre-cancerous skin condition. About 48 US veterans with fair skin and many pre-cancers will receive PDT on their face and forearms, with imipramine on one side and a placebo cream on the other. The goal is to see if imipramine reduces immune suppression caused by PDT, making the treatment work better and possibly less painful.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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Dayton VA Medical Center, Dayton, OH
RECRUITINGDayton, Ohio, 45428, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
imipramine (topical cream)
What this could lead to
If it works, this could make a common skin pre-cancer treatment more effective and less painful for veterans.
What could go wrong
This is a small, early Phase 2 trial with only 48 participants. The combination has not been tested in humans before, so it may not work as hoped or could cause unexpected skin reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.