New trial aims to delay prostate cancer progression with targeted local therapy
NCT ID NCT04787744
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This study for veterans with prostate cancer that has returned in a few spots (oligorecurrence) compares standard systemic therapy alone versus standard therapy plus PET-directed local treatment using surgery or radiation. The goal is to see if adding local therapy delays the cancer from becoming resistant to hormone therapy. About 464 participants will be enrolled across multiple VA centers.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PROSTATE CANCER are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Email: •••••@•••••
-
Bay Pines VA Healthcare System, Pay Pines, FL
RECRUITINGBay Pines, Florida, 33744, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Clement J. Zablocki VA Medical Center, Milwaukee, WI
RECRUITINGMilwaukee, Wisconsin, 53295-1000, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
RECRUITINGPhiladelphia, Pennsylvania, 19104-4551, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Durham VA Medical Center, Durham, NC
RECRUITINGDurham, North Carolina, 27705, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
TERMINATEDEast Orange, New Jersey, 07018, United States
-
Edward Hines Jr. VA Hospital, Hines, IL
RECRUITINGHines, Illinois, 60141-3030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Hunter Holmes McGuire VA Medical Center, Richmond, VA
RECRUITINGRichmond, Virginia, 23249, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Kansas City VA Medical Center, Kansas City, MO
TERMINATEDKansas City, Missouri, 64128-2226, United States
-
Louis Stokes VA Medical Center, Cleveland, OH
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Minneapolis VA Health Care System, Minneapolis, MN
ACTIVE_NOT_RECRUITINGMinneapolis, Minnesota, 55417-2309, United States
-
Richard L. Roudebush VA Medical Center, Indianapolis, IN
RECRUITINGIndianapolis, Indiana, 46202-2884, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
VA Ann Arbor Healthcare System, Ann Arbor, MI
RECRUITINGAnn Arbor, Michigan, 48105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
RECRUITINGBoston, Massachusetts, 02130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
RECRUITINGWest Los Angeles, California, 90073, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
VA Long Beach Healthcare System, Long Beach, CA
RECRUITINGLong Beach, California, 90822, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
VA NY Harbor Healthcare System, New York, NY
TERMINATEDNew York, New York, 10010-5011, United States
-
Washington DC VA Medical Center, Washington, DC
RECRUITINGWashington D.C., District of Columbia, 20422-0001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
William S. Middleton Memorial Veterans Hospital, Madison, WI
RECRUITINGMadison, Wisconsin, 53705-2254, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PET-directed local therapy (surgery or radiation)
What this could lead to
If successful, this approach could help men with recurrent prostate cancer delay the need for stronger hormone therapy and maintain a better quality of life for longer.
What could go wrong
This is a mid-stage trial, so results are not yet proven. Adding local therapy may increase side effects without improving outcomes, and the benefit may vary depending on the number and location of metastases.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.