Wearable sensors and brain signals may unlock new balance treatments for Parkinson's
NCT ID NCT06405334
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to understand why people with Parkinson's disease have balance problems and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes in 100 Veterans. The goal is to find brain pathways linked to balance issues so new treatments can be developed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Veterans with Parkinson's disease who experience postural instability and are treated at the Minneapolis VA Health Care System
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Aims 1 and 2 Inclusion criteria: * All Veterans with a clinical diagnosis of Parkinson's disease as made by their treating neurologist in Hoehn and Yahr stage 2-3 with the ability to give informed consent will be considered for possible participation in this study. * Veterans cannot be past stage 3 as our measures depend on physical independence and fall risk prediction is less useful after stage 3. * Capacity to consent will be assessed with the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC). * A score of less than 14.5 will be used as the cut-off to decide whether a Veteran is capable of consenting as the false positive rate is zero below this score with marginal increases in sensitivity above this score (89% sensitivity, 100% specificity). Aim 3 Inclusion criteria: * In addition to the inclusion criteria for Aims 1 and 2, Veterans with an implanted STN DBS lead with a Percept device in place. Exclusion Criteria: Aims 1 and 2 Exclusion criteria: * Veterans with dementia of sufficient severity to impair their ability to make healthcare related decisions for themselves will be excluded. * Veterans with other forms of parkinsonism (PSP, CBGD, etc.) will be excluded. * Veterans past H\&Y Stage 3 will be excluded. * Veterans with symptomatic orthostatic hypotension (defined as sustained drop in systolic blood pressure by 20 mmHg or diastolic blood pressure by 10 mmHg within 3 minutes of standing after being supine for five minutes) will also be excluded as this is an entity the investigators are not characterizing and could confound/bias the dataset. Aim 3: Exclusion criteria: * In addition to the exclusion criteria for Aims 1 and 2, Veterans with DBS leads implanted in other locations will be excluded.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Minneapolis VA Health Care System, Minneapolis, MN
RECRUITINGMinneapolis, Minnesota, 55417-2309, United States
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