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New exercise study aims to fight fatigue in kidney disease

NCT ID NCT04397159

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a combination of flywheel resistance and aerobic exercise can reduce fatigue and improve muscle function in veterans with chronic kidney disease who are not yet on dialysis. Researchers will measure changes in leg muscle endurance, perceived exhaustion, and blood flow. The study enrolls 30 participants aged 50 and older.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
flywheel resistance plus aerobic exercise
What this could lead to
If it works, this could point toward a simple exercise program to help veterans with kidney disease feel less tired and move better.
What could go wrong
This is a small, early study with only 30 participants, so results may not apply to everyone. Exercise may be hard for some to complete.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ambulatory (with or without a gait aid), 50 years of age or older diagnosed with chronic kidney disease (CKD) stages 3 \& 4 predialysis (as defined by eGFR 59-15 ml/min per 1.73m2) * Control group will include ambulatory individuals without clinical evidence of kidney disease (defined by eGRF \>60 ml/min per 1.73m2) within the last 12-months * All participants must be able to speak and read English, and demonstrate orientation to person, place, and time Exclusion Criteria: * adults diagnosed with acute renal failure/injury within the last 12-months * non-ambulatory individuals * adults who do not use the DC VAMC as their main site for renal care * those who have any uncontrolled cardiovascular * musculoskeletal disease * or other conditions that, in the opinion of the principal investigator, could make participation in the study unsafe * any orthopedic or joint pain which would prevent the participant from safely engaging in the study protocol * additionally, individuals with plans to relocate from the DC metro area within one year will not be eligible for the intervention portion of the study

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Conditions

The condition(s) this trial relates to.

chronic kidney disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease predialysis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Washington DC VA Medical Center, Washington, DC

    RECRUITING

    Washington D.C., District of Columbia, 20422-0001, United States