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Brain training after ICU: hope for dementia-like fog?

NCT ID NCT04353804

Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a computer-based brain training program can help people who survived a stay in the Intensive Care Unit (ICU) recover their thinking and memory skills. Many ICU survivors experience long-term cognitive problems similar to dementia. The study will involve 160 adults who recently left the ICU. Participants will use a computerized cognitive rehabilitation program to see if it improves their ability to handle everyday tasks like managing money and medicines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

160 people

The number who actually took part.

Started

Oct 2022

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults with a recent ICU stay (Medical or Surgical) requiring treatment for respiratory failure and/or shock (i.e., high-risk population) * No longer requiring ICU-level care Exclusion Criteria: * History of pre-existing severe cognitive impairment (IQCODE\>=3.8 or documentation in medical record) * Unwilling to commit to participation in the intervention * Under consideration for hospice * Primary residence over 100 miles from enrolling site if the patient is unwilling to return to the enrolling site for follow-up * Homeless without a secondary contact available * Severe substance abuse or neuropsychiatric disorder of a severity that prevents independent living * Active suicidal ideation * Any past or present behavior that may be deemed a safety risk for follow-up * Blind, deaf, or unable to understand/communicate in English * Required ICU level care less than 24 hours * Not capable of completing computer-based training * Co-enrollment in another study * Incarcerated

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive rehabilitation ICU Icu survivorship Intensive care unit

Contacts and locations

Locations

  • Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

    Nashville, Tennessee, 37212-2637, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37212, United States

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