Common antifungal drug shows promise against esophageal cancer
NCT ID NCT05563766
First seen Nov 05, 2025 · Last updated Jun 23, 2026 · Updated 28 times
Summary
This phase II trial tests whether adding itraconazole, a common antifungal medication, to standard chemoradiation can improve outcomes for people with resectable esophageal cancer. About 78 participants will receive itraconazole before and after standard treatment, then undergo surgery. The main goal is to see if more tumors completely disappear by the time of surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Durham VA Medical Center, Durham, NC
RECRUITINGDurham, North Carolina, 27705-3875, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Michael E. DeBakey VA Medical Center, Houston, TX
RECRUITINGHouston, Texas, 77030-4211, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Ann Arbor Healthcare System, Ann Arbor, MI
RECRUITINGAnn Arbor, Michigan, 48105-2303, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX
RECRUITINGDallas, Texas, 75216-7167, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Palo Alto Health Care System, Palo Alto, CA
RECRUITINGPalo Alto, California, 94304-1207, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Portland Health Care System, Portland, OR
RECRUITINGPortland, Oregon, 97207-2964, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Puget Sound Health Care System Seattle Division, Seattle, WA
RECRUITINGSeattle, Washington, 98108-1532, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Itraconazole (an antifungal drug)
What this could lead to
If it works, this could point toward a new way to boost the effectiveness of standard chemoradiation for esophageal cancer, potentially improving survival chances.
What could go wrong
This is a small, early-phase trial (78 people). The drug may not improve response rates as hoped, and side effects from adding itraconazole to chemoradiation are not yet fully known.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.