Could a gut supplement ease gulf war illness symptoms?
NCT ID NCT05367245
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 34 times
Summary
This phase 2 trial is testing whether a butyrate supplement (Cal-Mag Butyrate) can improve physical function in 120 veterans with Gulf War Illness. The study also looks at effects on fatigue, memory, gut health, and inflammation. Participants take the supplement or a placebo for several weeks, and researchers measure changes using health surveys and cognitive tests.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Miami VA Healthcare System, Miami, FL
RECRUITINGMiami, Florida, 33125, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Long Beach Healthcare System, Long Beach, CA
RECRUITINGLong Beach, California, 90822, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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VA Salt Lake City Health Care System, Salt Lake City, UT
RECRUITINGSalt Lake City, Utah, 84148-0001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Calcium-Magnesium Butyrate (a dietary supplement)
What this could lead to
If it works, this could point toward a treatment that improves physical function and reduces fatigue, gut issues, and cognitive problems in veterans with Gulf War Illness.
What could go wrong
This is a mid-stage trial with only 120 participants, so results may not apply to all veterans. The supplement may not work better than a placebo, and side effects are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.