Could a common ED drug ease breathing in COPD patients?
NCT ID NCT05937854
First seen Feb 17, 2026 · Last updated Jun 22, 2026 · Updated 20 times
Summary
This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will randomly receive either tadalafil or a placebo pill for 6 months, and researchers will track breathing, activity levels, and quality of life. The goal is to see if adding tadalafil to standard COPD care helps people feel better and move more.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Atlanta VA Medical and Rehab Center, Decatur, GA
RECRUITINGDecatur, Georgia, 30033-4004, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
RECRUITINGOmaha, Nebraska, 68105-1850, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Providence VA Medical Center, Providence, RI
RECRUITINGProvidence, Rhode Island, 02908-4734, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Rocky Mountain Regional VA Medical Center, Aurora, CO
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
RECRUITINGBoston, Massachusetts, 02130-4817, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tadalafil (also known as Cialis or Adcirca)
What this could lead to
If it works, this could offer a new way to reduce breathlessness and improve daily activity for people with COPD and high blood pressure in the lungs.
What could go wrong
This is a mid-stage trial with only 126 participants, so results may not apply to everyone. Tadalafil can cause side effects like headache, muscle aches, or low blood pressure, and it may not improve symptoms at all.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.