PULMONARY HYPERTENSION

This study looks at whether long-term exercise training can improve daily function and heart-lung health in people with pulmonary hypertension, a condition where blood pressure in the lungs is too high. About 104 adults who are stable on medication will take part. The goal is to …

This study tests whether sildenafil (the drug in Viagra) can help people with severe lung high blood pressure caused by rheumatic heart valve disease. Researchers will give 100 adults either sildenafil or a placebo for six weeks to see if it improves their walking distance and he…

This study tests whether two heart medications (empagliflozin and ranolazine) can help people with pulmonary hypertension and right heart failure. About 30 adults will receive either standard care alone or standard care plus one of the drugs. The main goal is to see if a larger s…

This study tests whether a mechanical heart pump (HeartMate 3) can help people with advanced heart failure live longer and avoid serious complications like stroke or the need for a heart transplant. About 850 participants will either receive the pump or continue with standard med…

This study tests whether a once-daily inhaled medication called treprostinil palmitil can help adults with pulmonary hypertension (high blood pressure in the lungs) caused by interstitial lung disease (lung scarring) walk farther. About 344 participants will receive either the dr…

This study tests an investigational drug called TX000045 in people with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure. About 180 adults will receive either the drug or a placebo for 24 weeks. The goal is to see if the drug improves bl…

This early-stage study tests whether a supplement called L-Citrulline is safe for preterm infants who have lung disease (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of this natural substance can reduce harmful inflammation. About 36 infants wil…

This study tests a fetal surgery called FETO (fetoscopic endoluminal tracheal occlusion) in pregnant women carrying babies with severe congenital diaphragmatic hernia (CDH). The goal is to see if temporarily blocking the baby's windpipe helps the lungs grow larger and improves su…

This study looks at the long-term safety and effects of an experimental medicine called PF-07868489 for people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lung arteries makes the heart work harder. Adults who completed a prior study of…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by scarring lung disease. About 20 adults will take part to see if the combination is safe and tolerable. The goal is to manage …

This study tests a remote monitoring system to better manage oxygen therapy in premature infants with bronchopulmonary dysplasia (BPD). About 70 babies born before 32 weeks will be enrolled. The goal is to reduce health complications and improve long-term outcomes by carefully co…

This study tests a new device for people with pulmonary hypertension, a condition where high blood pressure in the lungs strains the heart. The device is implanted to help the heart pump blood more easily. The study will check if the device is safe and works well in 30 adults wit…

This early study tests a new way to use a heart-lung machine (ECMO) to keep people with severe lung disease and heart failure alive until they can get a lung transplant. The approach uses a special tube placed across the heart's wall to improve blood flow. Only 4 participants wil…

This study looks at whether different oxygen levels can help preterm infants who have both a chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in the lungs (pulmonary hypertension). About 39 infants born extremely early will be enrolled. Researchers will m…

This study tests a stem cell transplant for people aged 8-24 with severe systemic sclerosis (scleroderma) that hasn't improved with standard treatments. The goal is to see if this approach is safer and still controls the disease. Participants receive high-dose therapy to reset th…

This study tests an oral medication called levosimendan in 230 adults with pulmonary hypertension and a type of heart failure where the heart pumps normally but is stiff. The main goal is to see if the drug helps people walk farther in six minutes compared to a placebo. Participa…

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve exercise ability in people with severe high blood pressure in the lungs caused by COPD. About 200 adults will receive either tadalafil or a placebo pill for 16 weeks. The main goal is to see if tho…

This study aims to see if voice recordings can help detect pulmonary hypertension, a serious heart and lung condition. Researchers at Mayo Clinic will collect voice samples from 7,000 people already scheduled for an echocardiogram. They will compare voice patterns to standard tes…

This study is testing whether a non-invasive, radiation-free chest monitor called electrical impedance tomography (EIT) can accurately detect pulmonary hypertension, a serious lung and heart condition. Currently, diagnosis requires an invasive procedure called right heart cathete…

This study tests whether an artificial intelligence (AI) tool that reads electrocardiograms (ECGs) can help doctors find undiagnosed pulmonary hypertension in people with interstitial lung disease. About 900 adults with severe lung scarring will be randomly assigned to have their…

This study is testing whether a special digital stethoscope that also records a single-lead ECG can help doctors spot signs of pulmonary hypertension (high blood pressure in the lungs). Researchers will collect heart and lung sound recordings from over 2,400 adults who are alread…

This study tests whether a 16-week home exercise program, guided by a smartwatch, can help children aged 8-18 with pulmonary hypertension become more active and improve their muscle strength and quality of life. Participants will wear activity trackers and follow a personalized e…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for 6 months, and n…

This study tests whether giving iron through a vein can improve exercise ability and daily function in people with pulmonary hypertension (high blood pressure in the lungs) who also have low iron. Many patients with this condition cannot absorb iron from pills, so intravenous iro…

This small pilot study is testing whether semaglutide, a drug already approved for diabetes and weight loss, is safe and tolerable for people with advanced lung diseases like COPD or pulmonary fibrosis. Eight participants will take the drug for 12 weeks and be monitored for side …

This study looks at why people with pulmonary arterial hypertension (PAH) lose muscle mass and how that affects their daily life and activity. Researchers will measure body composition, heart function, diet, and physical performance in 150 adults with PAH. No new treatments are t…

This study is observing 120 adults with pulmonary hypertension who are already taking the drug sotatercept at the Mayo Clinic. Researchers will track quality of life, hospital visits, medication changes, and side effects over time. The goal is to understand how well the drug work…

This study involves 100 people with suspected pulmonary hypertension who are already scheduled for a right heart catheterization. During the procedure, doctors will take two small blood samples from a specific position in the lung artery to analyze oxygen and other gas levels. Th…

This study looks back at medical records of 1000 people with COPD who had a special heart test. The goal is to learn more about a condition called pulmonary hypertension, where blood vessels in the lungs are under high pressure. By studying these records, researchers hope to bett…

This study tests a new ultrasound technology called NeoDoppler that can continuously monitor blood flow in the brains of sick and premature infants. Researchers will enroll 180 newborns, including healthy preterm and term babies as well as those with conditions like heart defects…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers want to find different patterns of heart strain to help develop better treatments in the future. The study involves 60 adults aged 40 and older with COPD.

This study aims to find genetic factors linked to pulmonary hypertension (high blood pressure in the lungs). Researchers will collect health surveys and saliva samples from 10,000 US adults aged 18 and older, both with and without the condition. Participation is online and takes …

This study aims to monitor the safety of targeted drugs for pulmonary hypertension (PH) by following 700 patients every 6 months using a computerized system. The main goals are to track side effects and deaths. Participants include people aged 3 months to 85 years with confirmed …

This study looks at how often people on dialysis develop high blood pressure in the lungs (pulmonary hypertension) and what factors contribute to it. Researchers will follow 70 adults on long-term dialysis for two years, using heart ultrasounds and other tests to track their cond…

This study is testing a new MRI technique that uses a special gas called hyperpolarized xenon to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if thi…

This study checks how well smartwatches measure oxygen levels in people with pulmonary hypertension, a condition that affects blood vessels in the lungs. Researchers will compare smartwatch readings to standard finger probes and blood tests at rest, after exercise, and while brea…

This study compares noninvasive heart ultrasound (echocardiogram) with invasive right heart catheterization to see if ultrasound can reliably measure heart and lung function. Researchers will study 3,000 people referred for catheterization, measuring heart output and oxygen use d…

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart muscle samples from 50 adults to find the best ways to diagnose and test new treatments for this condition. The go…

This study is a registry that will follow 900 adults who have both pulmonary hypertension (high blood pressure in the lungs) and interstitial lung disease (a type of lung scarring). The goal is to collect information on their health history and track how their condition changes o…

This study is testing a new device called HemoCept to see if it can accurately measure pressure in the heart's blood vessels during a standard procedure called right heart catheterization. About 50 adults with conditions like pulmonary hypertension or heart failure will take part…

This study is a national registry that collects information from 3,000 people with pulmonary hypertension (PH) treated at specialized centers across the U.S. Researchers will track how patients are diagnosed and treated, and follow them over time to see what factors lead to bette…

This study is creating and testing a questionnaire to see how much people with pulmonary arterial hypertension (PAH) know about their disease. Researchers will check if the questions make sense to patients and experts, and if the tool gives reliable results. Up to 200 adults with…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track patients' health, treatments, and outcomes over time. The goal is to better understand these conditions and improv…

This study looks at 40 adults getting chest radiation for cancer. Researchers will use PET/MR scans and blood tests before and after treatment to find early signs of heart and lung problems, like pulmonary hypertension. The goal is to better predict who might develop these side e…

This study is testing a new tool called the PVD-B65 risk score to see if it can accurately predict who is at higher risk of dying within one year for people with both chronic lung disease and pulmonary hypertension. Researchers will follow 100 adults and track their health outcom…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension. Researchers want to understand if diaphragm problems are linked to shortness of breath. No new treatments are being tested—this is an observat…

This study is creating a large database of information from 900 people who have pulmonary hypertension (high blood pressure in the lungs) or are at risk for it. Researchers will collect medical history, test results, and follow-up data over time. The goal is to improve understand…

This study looks at whether nicotinamide riboside, a form of vitamin B3, can improve how cells produce energy in people with a high-risk type of pulmonary hypertension (CPH). Ten adults with CPH will receive both the supplement and a placebo at different times. The goal is to mea…

This study is a registry that collects information from children and teens diagnosed with pulmonary hypertension (high blood pressure in the lungs). Researchers will follow their health over time to see how the disease progresses, how treatments work, and what affects long-term o…

This study follows people with pulmonary arterial hypertension (PAH) and healthy volunteers to see how the disease progresses. Researchers will use blood tests, heart and lung imaging, and walking tests to find new markers that could lead to better treatments. About 270 adults ag…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers want to find different patterns of heart strain to help design better treatments in the future. About 60 adults aged 40 and older with COPD will take part.

This study is building a large collection of blood samples and health information from 5,000 adults with congenital heart disease, pulmonary hypertension, or related conditions. Researchers will use this data to better understand how these diseases work and what affects patient h…

This study is testing new MRI techniques to see how the heart works during physical stress, like exercise or fluid changes. Researchers will compare healthy volunteers and people with heart conditions to better understand heart function. The goal is to improve diagnosis and care …

This study tests whether artificial intelligence (AI) can help doctors find a serious lung condition called pulmonary arterial hypertension (PAH) earlier in people with systemic sclerosis (scleroderma). Researchers will compare AI-based screening to traditional methods in 350 adu…

This study tests whether a special type of MRI, using inhaled xenon gas, can show how well the drug sotatercept is working in people with pulmonary arterial hypertension (PAH). PAH is a serious condition where blood vessels in the lungs narrow, making the heart work harder. The s…

This early-stage study tests a new medicine called F230 in 136 healthy adults to see if it is safe and how the body processes it. The drug is designed to treat pulmonary hypertension, a serious lung condition. Researchers will also check if food changes how the drug works. No dir…