New drug trial aims to ease breathing for heart failure patients

NCT ID NCT06616974

Recruiting now Disease control Sponsor: Tectonic Therapeutic Source: ClinicalTrials.gov ↗

First seen Dec 10, 2025 · Last updated May 25, 2026 · Updated 23 times

Summary

This study tests an investigational drug called TX000045 in people with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure. About 180 adults will receive either the drug or a placebo for 24 weeks. The goal is to see if the drug improves blood flow in the lungs and is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Almada
RECRUITING

Almada, 2805-267, Portugal
Auchenflower
RECRUITING

Auchenflower, Queensland, 4066, Australia
Augusta
RECRUITING

Augusta, Georgia, 30912, United States
Aurora
RECRUITING

Aurora, Colorado, 80045, United States
Austria
RECRUITING

Vienna, 1100, Austria
Baltimore
RECRUITING

Baltimore, Maryland, 21201, United States
Barcelona
RECRUITING

Barcelona, 08035, Spain
Belgrade
RECRUITING

Belgrade, 11000, Serbia
Białystok
RECRUITING

Bialystok, 15-276, Poland
Boise
RECRUITING

Boise, Idaho, 83706, United States
Boston
RECRUITING

Boston, Massachusetts, 02180, United States
Brussel
RECRUITING

Brussels, 1070, Belgium
Bucuresti
RECRUITING

Bucharest, 022328, Romania
Camperdown
RECRUITING

Camperdown, New South Wales, 2050, Australia
Camperdown
RECRUITING

Camperdown, 2050, Australia
Chermside
RECRUITING

Chermside, Queensland, 4032, Australia
Chicago
RECRUITING

Chicago, Illinois, 60453, United States
Chisinau
RECRUITING

Chisinau, Moldova
Christchurch
RECRUITING

Christchurch, 8011, New Zealand
Craiova
RECRUITING

Craiova, 200642, Romania
Dunedin
RECRUITING

Dunedin, 9016, New Zealand
Durham
RECRUITING

Durham, North Carolina, 27710, United States
Genk
COMPLETED

Genk, 3600, Belgium
Hobart
RECRUITING

Hobart, Tasmania, 7000, Australia
Indianapolis
RECRUITING

Indianapolis, Indiana, 46219, United States
Jacksonville
RECRUITING

Jacksonville, Florida, 32216, United States
Kragujevac
RECRUITING

Kragujevac, 34000, Serbia
Krakow
RECRUITING

Krakow, 31-202, Poland
Lisboa
RECRUITING

Lisbon, 1649-028, Portugal
Lublin
RECRUITING

Lublin, 20-090, Poland
Macquarie
RECRUITING

Macquarie, New South Wales, 2109, Australia
Madrid
RECRUITING

Madrid, 28034, Spain
Madrid
RECRUITING

Madrid, 28041, Spain
Mainz
RECRUITING

Mainz, 55131, Germany
Malvern
RECRUITING

Malvern, Victoria, 3145, Australia
McDonough
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McDonough, Georgia, 30253, United States
Minneapolis
RECRUITING

Minneapolis, Minnesota, 55414, United States
New Lambton
RECRUITING

New Lambton, New South Wales, 2305, Australia
New Lambton
RECRUITING

New Lambton, 2305, Australia
New York
RECRUITING

New York, New York, 10029, United States
New York
RECRUITING

New York, New York, 10075, United States
Nis, Belgrade
RECRUITING

Belgrade, Nis, 18108, Serbia
Omaha
RECRUITING

Omaha, Nebraska, 68198, United States
Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Phoenix
RECRUITING

Phoenix, Arizona, 85283, United States
Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
Pleven
RECRUITING

Pleven, 5800, Bulgaria
Plovdiv
RECRUITING

Plovdiv, 4001, Bulgaria
Port Arthur
RECRUITING

Port Arthur, Texas, 77642, United States
Porto
RECRUITING

Porto, 4099-001, Portugal
Richmond
RECRUITING

Richmond, Virginia, 23230, United States
Riga
RECRUITING

Riga, LV10002, Latvia
Rock Hill
RECRUITING

Rock Hill, South Carolina, 29732, United States
Salt Lake City
RECRUITING

Salt Lake City, Utah, 84112, United States
San Francisco
RECRUITING

San Francisco, California, 94143, United States
Santa Rosa
RECRUITING

Santa Rosa, California, 95405, United States
Santiago de Compostela ( Coruña )
RECRUITING

Santiago de Compostela, 15706, Spain
Scottsdale
RECRUITING

Scottsdale, Arizona, 85258, United States
Serbia
RECRUITING

Belgrade, 11040, Serbia
Sofia
RECRUITING

Sofia, 1700, Bulgaria
Sofia
RECRUITING

Sofia, 1750, Bulgaria
Sremska Kamenica
RECRUITING

Kamenitz, 21204, Serbia
St Louis
RECRUITING

St Louis, Missouri, 63110, United States
Sydney
RECRUITING

Sydney, New South Wales, 2010, Australia
Tampa
RECRUITING

Tampa, Florida, 33613, United States
Targu Mures
RECRUITING

Târgu Mureş, 540136, Romania
Tbilisi
RECRUITING

Tbilisi, Tb, 0186, Georgia
Tbilisi
RECRUITING

Tbilisi, 0159, Georgia
Tbilisi
RECRUITING

Tbilisi, 0167, Georgia
Tbilisi
RECRUITING

Tbilisi, 0191, Georgia
Toledo
RECRUITING

Toledo, Ohio, 43606, United States
Toledo
RECRUITING

Toledo, 45007, Spain
USA
RECRUITING

Louisville, Kentucky, 40202, United States
Ukraine
RECRUITING

Kyiv, 01135, Ukraine
United States
RECRUITING

Norfolk, Virginia, 23507, United States
Valencia
RECRUITING

Valencia, 46010, Spain
Valencia
RECRUITING

Valencia, 46015, Spain
Waco
RECRUITING

Waco, Texas, 76712, United States
Warsaw
RECRUITING

Warsaw, 04-628, Poland
Wollongong
RECRUITING

Wollongong, New South Wales, 2500, Australia
Wrocław
RECRUITING

Wroclaw, 50-556, Poland
Yerevan
RECRUITING

Yerevan, 0006, Armenia
Yerevan
RECRUITING

Yerevan, 0025, Armenia
Yerevan
RECRUITING

Yerevan, 0087, Armenia
York
RECRUITING

York, Pennsylvania, 17403, United States
Łodź
RECRUITING

Lodz, 91-347, Poland

Conditions

Explore the condition pages connected to this study.

HEART FAILURE WITH PRESERVED EJECTION FRACTION PULMONARY HYPERTENSION