PULMONARY HYPERTENSION

This study tests whether adding telaglenastat to standard treatment can lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 people with mild to moderate symptoms will receive the drug for a set period. The drug is …

This study looks at whether the drug sotatercept can help repair damaged blood vessels in the lungs of people with pulmonary arterial hypertension (PAH). Researchers will use special imaging techniques to see if the blood vessels become healthier over 9 months. The study plans to…

This study tests a device that uses radiofrequency energy to calm overactive nerves in the lung arteries of people with heart failure and a specific type of high blood pressure in the lungs. About 750 adults who are stable on heart failure medications will either get the procedur…

This study tests whether inhaled nitric oxide can help newborns with a hole in their diaphragm (congenital diaphragmatic hernia) who also have high blood pressure in their lungs. About 40 babies will receive the gas, and doctors will check if their oxygen levels improve. The goal…

This study looks at the long-term safety of an inhaled medication called treprostinil palmitil inhalation powder (TPIP) for people with pulmonary hypertension caused by interstitial lung disease. About 344 adults who finished a previous study will take the drug and be monitored f…

This study looks at using ultrasound instead of X-ray to guide a thin tube (catheter) into the heart's artery for people with pulmonary hypertension. The goal is to see if ultrasound is safe, fast, and accurate. About 35 adults will take part, and the main focus is on how well th…

This study looks at whether a 16-week home exercise program can improve how well the heart and lungs work in people with pulmonary hypertension linked to interstitial lung disease. About 30 adults will follow a structured exercise plan at home, and researchers will measure change…

This study will use artificial intelligence and 3D ultrasound to measure how well the right side of the heart works together in healthy adults and people with certain heart conditions. Researchers will enroll about 2,640 participants to establish normal values and see if these me…

This study will follow 400 people receiving a stem cell transplant for blood cancers to learn why some develop serious heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, EKGs, and blood tests to find early warning signs. Th…

This study will check if people with more severe sleep apnea also have higher blood pressure in their lungs. About 55 adults with sleep apnea will have their heart and lungs checked using ultrasound. No new treatments are tested—the goal is simply to understand the link between t…

This study will collect heart sound recordings from 1,000 adults undergoing routine echocardiograms. Researchers will test whether artificial intelligence (AI) can accurately detect pulmonary hypertension and other cardiovascular diseases from these recordings. The goal is to val…

This study looks at why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will collect blood, lung fluid, and tissue samples from 105 adults having lung surgery. They will compare three groups: those with lung dis…

This study is testing a smartphone app called MedlyPeds that lets kids with heart disease send daily health updates to their doctors from home. About 30 children aged 8-18 with various heart conditions will use the app for 3 months. The goal is to see if the app is easy to use an…

This study will follow 300 adults with a portosystemic shunt (an abnormal blood vessel connection between the liver and other organs) who also have pulmonary hypertension (high blood pressure in the lungs). Researchers aim to learn how common this condition is, what symptoms appe…

This study will follow 200 adults with severe pulmonary hypertension who are hospitalized for acute right heart failure. Researchers across Europe will collect medical data to see how different treatments and care pathways affect survival and the need for lung transplant. The goa…