PULMONARY HYPERTENSION

This study tests whether six weeks of special breathing exercises (called inspiratory muscle strength training) can improve heart and lung function in people with pulmonary hypertension, a condition where high blood pressure strains the heart and lungs. Four adults already schedu…

This study is testing the safety of an inhaled dry powder drug called LIQ861 (treprostinil) in 80 adults with pulmonary hypertension (high blood pressure in the lungs) linked to lung disease or other causes. Participants receive the drug through an inhaler, and researchers monito…

This study looks at a different way of clamping the umbilical cord after birth for babies born with a hole in their diaphragm (congenital diaphragmatic hernia). The new method, called physiological-based cord clamping, waits until the baby's lungs have filled with air before clam…

This study looks at how well and how safely the drug bevacizumab works for people with hereditary hemorrhagic telangiectasia (HHT) who have severe liver issues causing high heart output and possible heart failure. Researchers will check heart function before and after 6 months of…

This study tests an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by scarring lung disease. About 135 adults will receive either the drug or a placebo for 16 weeks. The goal is to see if the drug improves blood flow in the lungs and w…

This study looks at the long-term safety of a drug called ralinepag for people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug is …

This study tests an experimental drug called MK-5475 (frespaciguat) in adults who have both COPD and pulmonary hypertension (high blood pressure in the lungs). The main goal is to see if the drug helps people walk farther in 6 minutes after 24 weeks compared to a placebo. About 1…

This study tests a new computer tool called IMPULSE that helps doctors read heart ultrasound images to find pulmonary hypertension (high blood pressure in the lungs) earlier. About 200 people with unexplained shortness of breath or risk factors will take part. The goal is to see …

This study tests whether special screening methods can find pulmonary hypertension (high blood pressure in the lungs) earlier in people with interstitial lung disease. About 300 adults with various types of ILD will be screened using heart catheterization to confirm the condition…

This study looks at whether a supervised exercise program can improve heart function, exercise capacity, and quality of life in people with heart failure and pulmonary hypertension. About 40 adults with stable heart failure will take part. The goal is to see if exercise can lower…

This study is observing 350 adults with pulmonary hypertension to see if certain markers in urine and blood are linked to worsening kidney function. Researchers will track kidney decline, need for dialysis, and death. The goal is to better understand the connection between these …

This study is looking at two substances in the blood, Activin-A and FSTL3, to see if they can help predict how people with pulmonary hypertension (high blood pressure in the lungs) will do over time. Researchers will follow 550 adults with different types of this condition for tw…

This study looks at whether wearing an activity tracker (like a Fitbit) can give doctors a better idea of how someone with pulmonary hypertension will do over 12 weeks, compared to the standard 6-minute walk test. About 230 adults with this condition will wear an accelerometer an…

This study was designed to look for early signs of high blood pressure in the lungs after mitral valve surgery. Researchers planned to use blood tests and heart imaging to find problems before they become dangerous. However, the study was withdrawn before enrolling any participan…

This study checks if a 2-minute step test works as well as the standard 6-minute walk test for people with pulmonary hypertension. About 35 adults will do both tests while wearing a portable device that measures oxygen use and heart rate. The goal is to see if the shorter, simple…

This study looks at whether measuring certain substances in the blood of people with pulmonary hypertension (PH) can help doctors pick the best treatment. About 100 adults getting a standard heart test for PH will also have these extra measurements. The goal is to see if this lea…