Could a common hormone be better for blood pressure during lung surgery?

NCT ID NCT07614438

Disease control Sponsor: Fondation Hôpital Saint-Joseph Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two drugs, vasopressin and norepinephrine, given during and after surgery to remove chronic blood clots from the lungs. The goal is to see which drug better controls blood pressure in the lungs without harming the rest of the body. About 90 adults scheduled for this surgery will take part, and their lung artery pressure will be measured right after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Vasopressin
What this could lead to: If vasopressin works better, it could become the preferred drug to manage blood pressure during and after this lung surgery, potentially improving recovery.
What could go wrong: This is a small, early-phase trial with only 90 participants at one hospital. The drug may not show a clear benefit over the standard treatment, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years; * Patient scheduled for pulmonary endarterectomy surgery; * In women of childbearing potential: negative serum pregnancy test and use of adequate contraception; * Affiliation to the French social care service; * Patient able to understand and sign a written informed consent form. Exclusion Criteria: * Emergency surgery; * Mesenteric ischemia and/or acute coronary syndrome within the month preceding the intervention; * Patients with documented mesenteric artery stenosis; * Impossibility to insert the pulmonary artery catheter (anatomical or technical issue); * Preoperative administration of norepinephrine and/or inotropic drugs (dobutamine, isoproterenol, epinephrine) or patients assisted by veno-venous or veno-arterial ECMO before surgery; * Known allergy to the active substance vasopressin or to any of its excipients; * Concomitant coronary bypass procedure or other combined surgery (i.e. valve replacement); * mPAP\<25 mmHg on preoperative right heart catheterization; * Patient with preoperative natremia below 130 mol/L; * Patient participating to another interventional clinical trial; * For females only: documented pregnancy or lactation; * Patient under tutorship, curatorship or legal protection; * Patient deprived of liberty.

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Conditions

The condition(s) this trial relates to.

chronic thromboembolic pulmonary hypertension pulmonary hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Chronic pulmonary thromboembolism Pulmonary hypertension Vasopressor

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could a common hormone be better for blood pressure during lung surgery?

What the study statuses mean