Va Office Of Research And Development

This phase 2 trial tested whether combining testosterone therapy with a special type of electrical stimulation (long pulse width) could rebuild leg muscle in 12 people with spinal cord injury whose muscles no longer respond to standard electrical stimulation. Participants receive…

This pilot study tested whether combining neuromuscular electrical stimulation with daily vitamin D could improve bone health in veterans with chronic spinal cord injury. Six participants underwent 9 months of treatment, with bone changes measured by MRI and DXA scans. The goal w…

This study tested a new therapy called TR&ST that involves both a veteran at risk for suicide and their romantic partner. The goal was to see if working together as a couple could reduce suicidal thoughts more than standard VA care. The study included 104 veterans and their partn…

This study tested a telehealth program for veterans who drink too much and have high blood pressure or other heart risks. The program included four therapy sessions by video call, a coaching call, and daily text messages for a month. The goal was to see if this approach was pract…

This study tested a specialized support program for veterans with both bipolar disorder and substance use problems after they leave the hospital. Half of the 138 participants received extra counseling and monitoring, while the other half got standard safety checks. The goal was t…

This study looked at whether having a live-in support partner helps Veterans lose more weight. 300 Veterans with obesity joined a 72-week weight management program, either with a partner or alone. The goal was to see if teamwork leads to better weight loss and maintenance.

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested whether a person with chronic paralysis from a spinal cord injury could control their own hand using brain signals. One participant used a brain implant to send commands to small electrodes in their arm and hand, which then stimulated muscles to create different…

This study tested two different texting programs to help Veterans with type 2 diabetes manage their blood sugar. 366 Veterans took part. One program sent standard daily tips, while the other let Veterans customize the messages they received. The goal was to see which approach wor…

This study tested whether a nurse-led program could help veterans with HIV lower their blood pressure and reduce their risk of heart disease. 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to help manage blood pressure…

This study tested whether adding the antibiotic rifampin to standard treatment helps diabetic patients with foot bone infections avoid amputation. Over 800 veterans took part, receiving either rifampin or a placebo for six weeks. The goal was to see if rifampin improves amputatio…

This study tested whether peer specialists—people who have serious mental illness themselves and are trained to help others—can effectively deliver two types of therapy: Cognitive Behavioral Social Skills Training (CBSST) and Social Skills Training (SST). The goal is to help vete…

This completed study tested a remote, self-guided lifestyle program for 696 veterans with obesity and obstructive sleep apnea. Participants watched videos, completed handouts, and tracked their eating and activity, with optional coaching. The goal was to see if this low-cost appr…

This completed phase 3 trial tested whether a lifestyle program (diet and exercise) plus the drug metformin could reverse frailty and sarcopenic obesity in 114 older veterans aged 65-85. Participants followed a weight-loss diet and exercised three times a week, while taking metfo…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This completed study tested whether combining transcranial magnetic stimulation (TMS) with brief cognitive behavioral therapy (BCBT) could reduce suicide behavior in 55 high-risk veterans. Participants had a recent suicide attempt or strong suicidal thoughts. The goal was to see …

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goa…

This study looked at whether giving extra education and encouragement to diabetic foot ulcer patients helps them wear their prescribed walking boot more often. The boot is standard care, but many patients don't wear it enough. The study enrolled 18 veterans and measured boot wear…

This study tested whether probenecid, a medicine usually used for gout, can improve heart function and exercise ability in veterans with heart failure. About 99 veterans with a specific type of heart failure took probenecid twice daily for 180 days. Researchers measured changes i…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested a simple mental technique called WOOP (Wish, Outcome, Obstacle, Plan) to help veterans with obesity lose weight. About 405 veterans used WOOP along with the VA's telephone weight-loss program MOVE! to see if it boosted motivation and weight loss. The goal was to…

This study tested a new group program called Project Life Force against standard care for veterans at high risk of suicide. The program helps veterans build and improve their personal safety plans over 10 sessions using skills like emotion regulation and coping. The goal was to s…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35 to 70 took part. Researchers measured bone strength using special scans and blood tests over 12 months to see if tes…

This study tested a non-invasive brain stimulation method called rTMS to help veterans with alcohol use disorder stay sober. 49 veterans received either real or fake (sham) rTMS, and researchers tracked their alcohol use for 6 months. The goal was to see if rTMS could reduce rela…

This study tested whether long-term aerobic exercise can slow the progression of Parkinson's disease. Researchers enrolled 57 adults with mild to moderate Parkinson's to see if regular exercise improves movement, thinking, and driving safety. The goal is to find a low-cost, acces…

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study tested whether a small wearable sensor, combined with a smart computer program, could detect early signs of worsening heart failure and alert doctors to adjust treatment before a hospital stay is needed. Researchers enrolled 176 veterans with heart failure and randomly…

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life,…

This study tested a weight management program designed specifically for veterans with PTSD who are overweight or have obesity. The program added extra support to standard PTSD care to help overcome barriers like stress and low motivation. 174 veterans took part to see if the prog…

This study tested whether ibudilast, a drug that reduces brain inflammation, could help people addicted to methamphetamine. Researchers measured changes in brain function and thinking skills in 176 participants. The goal was to find a medication to support recovery, not to cure t…

This study tested a weight loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. The program used a smartphone app and support from peer specialists to help participants lose weight and walk farther. T…

This study checked whether 3D-printed nasal swabs work as well as standard swabs for diagnosing COVID-19. About 1,179 people who had COVID-19 symptoms or were recently exposed took part. Researchers compared the new swabs' accuracy and safety, like nosebleed risk, to the usual on…

This study tested whether an electronic self-report screening system (eScreening) helps VA clinics detect depression, PTSD, alcohol problems, and suicide risk more quickly and more often in newly enrolled post-9/11 veterans. Researchers compared screening rates and referral times…

This study tested a program to help Veterans at risk for suicide by making their homes safer. The program provided free safety devices for firearms and medications, along with counseling. Researchers wanted to see if Veterans would take part and find the program helpful. The stud…

This study looked at whether a heart-healthy, low-salt diet (the DASH diet) could prevent heart failure in older Veterans with high blood pressure, obesity, and metabolic syndrome. 71 participants followed the diet and researchers measured changes in artery stiffness and heart st…

This study tested whether a simple checklist could reduce MRSA infections after joint replacement or heart surgery in over 23,000 veterans. The checklist included steps like testing for MRSA before surgery and using special cleaning methods. The goal was to see if this approach c…

This study looked at over 5,000 people with kidney disease who needed an angiogram (a test that uses dye to see blood vessels). The goal was to see if giving sodium bicarbonate (a type of baking soda) or N-acetylcysteine (a common supplement) could prevent serious problems like k…

This study tested whether adding the sleep medication eszopiclone (Lunesta) to brief behavioral therapy improves sleep quality and CPAP use in veterans with PTSD and complex insomnia. Fifty-three veterans who had trouble sticking with CPAP therapy for sleep apnea took part. The g…

This study looked at whether Tai Chi or a wellness program could help Gulf War Veterans with chronic pain, fatigue, and mood problems. 114 Veterans took part, with sessions done in person or later by video due to COVID-19. The goal was to see if these gentle mind-body approaches …

This study tested a brief form of cognitive behavioral therapy (bCBT) for Veterans with anxiety. 225 Veterans from three VA medical centers received either bCBT (in-person or by video) or usual care. The goal was to see if this short therapy helps reduce anxiety symptoms better t…

This study tested a therapy called Impact of Killing (IOK) for veterans with PTSD caused by moral injury—distress from killing or being responsible for a death in war. One hundred veterans received either IOK or a standard PTSD therapy over 10 sessions. The goal was to see if IOK…

This study tested a phone-based program called Caregiver SOS for employed people caring for Veterans with depression, anxiety, PTSD, or brain injury. The program offers six one-hour sessions over 3-4 months to help manage stress and balance work and caregiving. Researchers measur…

This study tested a rehabilitation program called Live Long Walk Strong in 151 veterans aged 50 and older who had trouble walking. The program focused on improving strength, balance, and other skills that help with mobility. Researchers measured walking speed and other physical a…

This study tested a 10-week group therapy called START-PTSD for 45 veterans with PTSD who had declined standard trauma-focused treatments. The therapy helps veterans identify and gradually reduce 'safety aids'—behaviors like avoiding certain places or using mental distractions—th…

This study tested whether a brief cognitive behavioral therapy program (six 30-minute sessions) can help veterans with chronic musculoskeletal pain improve their daily functioning and reduce pain-related distress. 184 veterans from primary care clinics took part, with some receiv…

This pilot study tested whether a TENS device, which sends mild electrical pulses through the forehead, is safe and practical for treating chronic eye pain in veterans. Thirty-nine adults with persistent eye pain for at least six months used the device at home for up to 20 minute…

This study tested whether adding a smartphone app (CBT MobileWork-V) to standard cognitive behavioral therapy helps veterans with depression learn and use therapy skills better. Fifteen OEF/OIF/OND veterans with depression took part. The app was designed to make it easier to prac…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This completed trial tested a personalized version of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) for veterans with hoarding disorder. The therapy was delivered at home via telemedicine and home visits over 24 sessions. Researchers compared it to standard case m…

This study tested a program called PEACE for veterans leaving a psychiatric hospital. The program includes a one-hour talk about suicide prevention, seven follow-up calls, and a mobile app to help veterans feel connected. Researchers compared this extra support to standard care a…

This study tested whether taking branched-chain amino acids (BCAAs) can improve sleep and thinking in veterans who have had a mild traumatic brain injury. 160 veterans were randomly assigned to receive different doses of BCAAs or a placebo for 12 weeks. The main goal was to see i…

This study tested a program called Patient Priorities Care for older veterans with multiple chronic conditions. The program helps patients talk with their doctor about what matters most to them and what they are willing to do. The goal was to see if this approach reduces the burd…

This completed VA study tested two ways to help more veterans with chronic insomnia get brief behavioral treatment (BBTI) in primary care clinics. Over 277,000 veterans were included across four VA medical centers. The study compared training providers alone versus training plus …

This pilot study tested a brief virtual mindfulness program called RECLAIM in 36 veterans who had difficulty adjusting to civilian life after service. The program aimed to reduce depressive symptoms and improve community reintegration. Participants completed questionnaires about …

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested whether MitoQ, a supplement that targets cell energy centers, can reduce fatigue in people with multiple sclerosis. 45 participants took either 20 mg, 40 mg, or a placebo daily for 12 weeks. Researchers measured fatigue using a standard survey to see if MitoQ ma…

This study tested an app called EMPOWER-ED that provides education and tools to help veterans reduce or stop long-term benzodiazepine use. 170 veterans who had been taking these medications for at least 3 months participated. The app is designed to support self-managed tapering, …

This study tested whether an online program for insomnia could help veterans with COPD sleep better and feel better. 13 veterans were randomly assigned to either the online insomnia treatment or online education about sleep. The goal was to see if the treatment improved sleep qua…

This study tested whether orofacial myofunctional therapy (OMT) — simple tongue and throat exercises done during the day — can improve breathing during sleep in people with mild-to-moderate sleep apnea. 209 adults with sleep apnea participated, comparing OMT to a placebo exercise…

This study tested whether adding oxytocin (a natural hormone) to standard talk therapy helps Veterans with PTSD feel better faster and stay in treatment longer. About 180 Veterans took part, receiving either oxytocin or a placebo alongside therapy sessions. The goal was to see if…

This study tested a behavioral sleep treatment in 36 veterans who have PTSD, insomnia, and sleep apnea. The goal was to see if improving sleep also improves quality of life and daily functioning. Participants attended therapy sessions and reported their sleep and well-being throu…

This study looked at whether mindfulness training could help veterans with PTSD who struggle with anger and aggression. 61 veterans took part. The goal was to see if learning to focus on the present moment could help them control angry feelings and reduce aggressive behavior.

This study tested a shorter version of Cognitive Processing Therapy (CPT) for Veterans with PTSD. Many Veterans drop out of the standard 12-session therapy, missing the most helpful parts. The goal was to find which therapy components work best and deliver them in fewer sessions …

This study tested a program called EMPOWER for veterans who had already completed trauma-focused therapy for PTSD and seen improvement. The program gave veterans a workbook and four therapist check-ins over 12 weeks to help them keep using therapy skills, manage symptoms, and sta…

This study tested a program called Whole Health STEPS for Veterans with mental health concerns who are not in mental health treatment. The program uses a peer support specialist to help Veterans set and work toward wellness goals, with increasing support as needed. The goal was t…

This study tested whether an 8-week mindfulness program (MBSR) could help people with Parkinson's disease feel better in their daily lives. 107 participants were randomly assigned to either MBSR or a supportive education group. Researchers measured changes in quality of life, anx…

This study developed and tested a mobile website called LIMIT to help veterans on long-term opioid therapy safely reduce their dose while managing chronic pain. 44 veterans participated, using either the LIMIT app or a pain diary app for 6 months. The goal was to see if the tool …

This study tested two online programs designed to help people with multiple sclerosis manage spasticity (muscle tightness) in their legs. Participants attended two video classes that included education and stretching exercises. The goal was to see if these programs could reduce t…

This completed study tested two types of telehealth cognitive behavioral therapy (CBT) in 48 veterans with chronic pain who also felt lonely. One therapy focused on loneliness, the other on coping with pain. Researchers measured changes in loneliness, social interactions, and pai…

This completed VA study tested whether a single therapy, called Transdiagnostic Behavior Therapy (TBT), works as well as separate, disorder-specific therapies for veterans with PTSD, major depression, or panic disorder. 304 veterans participated, and researchers measured symptoms…

This study looked at whether 6 months of supervised exercise training could reduce PTSD symptoms and improve physical health in older veterans with PTSD. 80 veterans took part, with one group doing exercise and another receiving health education. The goal was to see if exercise c…

This pilot study tested whether trained peer specialists—veterans who have faced similar challenges—could support fellow veterans at high risk for suicide. Over three months, 17 veterans received one-on-one mentoring focused on building hope, connection, and meaning in their comm…

This study looked at how partnered tango dancing affects brain activity in people with Parkinson's disease. Researchers measured brain signals during leg movements before and after dance training. The goal was to see if dance could improve motor control by changing how brain regi…

This study tested whether a special sound therapy, called notched noise, could reduce tinnitus (ringing in the ears) in 108 Veterans. Participants wore hearing aids that played either notched noise (sound with the tinnitus frequency removed) or regular broadband noise. The goal w…

This completed study looked at why veterans with Long COVID feel so tired and tested a very simple home-based resistance exercise program (just one day a week for 8 weeks) to see if it's safe and feasible. Only 21 veterans aged 50 and older took part. The goal was to understand t…

This study tested whether adding virtual coaching to an online insomnia program helps veterans sleep better. 244 veterans with insomnia were randomly assigned to the digital program with coaching or with minimal contact. The coaching provided support and guidance to help veterans…

This study tested special exoskeleton footwear designed to assist walking in people over 40 with and without peripheral artery disease (PAD). Researchers measured how the shoes affected walking mechanics, muscle oxygen, and energy use, and asked participants about comfort and fat…

This study tested a walking program for veterans with chronic pain who are also being treated for opioid use disorder. The program included pain education and a pedometer to track steps. Researchers wanted to see if it was feasible and acceptable for this group.

This study tested whether adding cannabidiol (CBD) to standard talk therapy helps reduce PTSD symptoms in military Veterans. 136 Veterans received either CBD or a placebo alongside prolonged exposure therapy. The goal was to see if CBD could make the therapy work better and faste…

This study tested whether a natural brain chemical called pregnenolone can reduce PTSD symptoms in Iraq and Afghanistan veterans. 96 veterans with PTSD took either pregnenolone or a placebo for 10 weeks and had their symptoms checked regularly. The goal was to see if the suppleme…

This study tested whether neuromuscular electrical stimulation (NMES) can help Veterans with blood cancers maintain physical function and reduce fatigue during stem cell transplant. 46 participants used NMES while in the hospital. The goal was to see if this approach could preven…

This study tested a telehealth program (CBT-TS) to help 300 veterans on long-term opioids for chronic pain feel more willing to try non-drug treatments like therapy or exercise. The goal was to reduce pain and reliance on opioids. Results will show if changing beliefs about these…

This study tested whether custom 3D printed insoles can reduce pressure on the bottom of the feet for people with diabetes who are at risk for foot ulcers. Thirty adults participated, wearing the insoles during lab visits while their foot pressure and movement were measured. The …

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part, and their daily step counts were measured. The goal was to see if this approach improves physica…

This study looked at whether adding a short writing therapy (Written Exposure Therapy) to a 28-day residential substance use program helps veterans who have both PTSD and substance use disorders. Fifty-six veterans took part. The goal was to see if the writing therapy was practic…

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve qualit…

This study tested a new 8-week group program called Mindful Action for Pain (MAP) for veterans with chronic pain. MAP combines mindfulness meditation with proven strategies to help people live better despite pain. The goal was to see if it could reduce how much pain interferes wi…

This study looked at whether having a pharmacist check in with older Veterans via video call at home could improve how they take their medications. The study included 304 Veterans who had at least two chronic conditions and took five or more daily medicines. The goal was to reduc…

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study tested a phone-based coaching program for veterans with type 2 diabetes who feel stressed or overwhelmed by daily self-care tasks like checking blood sugar and taking insulin. The program gave personalized advice and support to help reduce that stress and improve blood…

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This pilot study tested a brief text-based intervention to help veterans with social anxiety reduce safety behaviors (like avoiding eye contact or rehearsing sentences). 23 veterans enrolled in a work therapy program participated. The goal was to see if this approach is feasible …

This study tested whether adding a non-invasive brain stimulation technique called tDCS to physical therapy helps stroke survivors walk better. 44 people who had a stroke at least 6 months earlier took part. The goal was to see if the combination improved walking speed and functi…

This study tested whether morning bright light therapy could improve sleep and reduce pain in 77 veterans with chronic mild traumatic brain injury (mTBI). Participants had ongoing sleep problems and moderate to severe pain. The goal was to see if better sleep leads to less pain a…

This study tested a type of talk therapy called Acceptance and Commitment Therapy (ACT) to help veterans with PTSD improve their social support and relationships. 107 veterans took part, and the therapy focused on helping them feel less isolated and more connected to family and f…

This study tested two sleep medications, trazodone and eszopiclone, in 673 veterans with PTSD-related insomnia. The goal was to see if these drugs could reduce insomnia symptoms over 12 weeks. Participants were adults aged 18-75 with military-related PTSD and insomnia. The study …

This study tested a 10-week, at-home cognitive training program for 9 veterans with major depression and a recent suicide attempt. The program aimed to improve decision-making and reduce depression through problem-solving exercises delivered via video calls. Early results suggest…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested whether a combined speech and exercise program delivered via telemedicine can improve speech clarity in people with Parkinson's disease. 104 veterans with speech problems took part. The goal was to see if remote training could help them communicate better in dai…

This study tested a personalized version of cognitive processing therapy (CF-CPT) for veterans with PTSD. 179 veterans participated to see if tailoring therapy to individual needs improves daily functioning, quality of life, and treatment completion compared to standard therapy. …

This study looked at whether a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) can help veterans who also have serious mental illnesses like schizophrenia or bipolar disorder. 47 veterans took part to see if the therapy was acceptable and practi…

This study tested a home-based program to help aging veterans with a history of traumatic brain injury (TBI) improve their thinking skills, such as attention and planning. Twenty-nine veterans aged 65 and older used telehealth technology to complete cognitive exercises from home.…

This study tested whether veterans with chronic low back pain can reduce pain and improve daily function by learning self-administered acupressure. About 300 veterans participated, with half using a tablet app to guide daily acupressure sessions for 6 weeks. The goal was to see i…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can relieve pain, headaches, depression, and other symptoms in 204 veterans with Gulf War Illness. Participants received rTMS, a non-invasive brain stimulation, and reported changes in pain, m…

This study tested whether specially designed shoes (carbon fiber or spring-loaded) could help people with peripheral artery disease (PAD) walk farther and with less pain. Ten veterans with PAD wore the shoes for three months. Researchers measured changes in walking distance and c…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested a therapy called ACT-MI for veterans struggling with moral injury—pain from events that went against their values. 74 warzone veterans took part to see if the therapy was acceptable and practical. The goal was to help them live meaningful lives, not to cure a di…

This study tested a problem-solving program delivered by phone and online for 210 Hispanic caregivers of veterans who had a stroke. The goal was to reduce caregiver depression and burden, and improve their quality of life. The program was adapted to be culturally relevant for His…

This study tested whether magnetic stimulation to the front of the brain could help older veterans stick to a home exercise program using Nintendo Wii-Fit. 72 sedentary veterans aged 60+ were asked to exercise 45 minutes daily, five days a week for 12 weeks. Those who struggled w…

This study tested a program called Compensatory Cognitive Training (CCT) in 21 veterans with PTSD who still had memory and attention problems after standard PTSD treatment. The goal was to see if CCT could help improve their thinking skills and daily functioning. The study was sm…

This study tested two different 2-month training programs to help veterans with psychosis improve their social interactions and quality of life. 113 veterans took part. The goal was to see which training worked better for everyday social situations.

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study looked at whether giving repeated doses of ketamine (compared to a placebo) could help veterans with PTSD feel better faster while they also received a standard talk therapy called Prolonged Exposure. About 75 veterans took part. The goal was to see if ketamine could s…

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This study tested a behavioral program to help older veterans with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. About 100 veterans who had stopped using their PAP device worked with a sleep coach over several sessions. The goal was t…

This study tested whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) could improve memory and thinking in 32 older veterans with mild cognitive impairment or dementia. Participants received rTMS sessions, and researchers measured changes i…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study looked at whether two types of talk therapy—Behavioral Therapy and Cognitive Therapy—can help Gulf War Veterans who have trouble sleeping. Fifty veterans took part, and their sleep problems were measured using a standard questionnaire. The goal was to see which therapy…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study looked at whether a 16-week program of aerobic and resistance exercise could improve heart and muscle health in 33 HIV-infected veterans aged 50 and older. Participants did treadmill tests and heart imaging to measure changes in fitness and inflammation. The goal was t…

This study tested whether placing mild electrical stimulation on the skin over the spine could help raise and stabilize low blood pressure in veterans with spinal cord injury. Ten participants with injuries at or above the T6 level took part. The goal was to find the best electro…

This study tested a specially adapted sleep therapy, called Sleep-SMART, for 30 older veterans who have both mild cognitive impairment (MCI) and chronic insomnia. The therapy combines standard insomnia treatment with extra memory and thinking strategies to help veterans learn and…

This study tested whether transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic fields to stimulate specific brain areas — can improve daily functioning in veterans with PTSD. Researchers compared real TMS to a sham (fake) treatment in 59 veterans.…

This study tested a short, non-medication anxiety treatment called VAST for veterans in primary care. About 170 veterans with anxiety symptoms were randomly assigned to receive VAST or usual care. The goal was to see if VAST reduces anxiety and improves daily life better than sta…

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The goal was to reduce distress and help them reintegrate into civilian life. 176 veterans participated, and the wo…

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was pract…

This small study tested whether a special laser treatment can help veterans with leg amputations who have painful scars that make wearing their artificial limb hard. Ten veterans received the laser therapy, and researchers measured changes in pain, scar appearance, walking abilit…

This study tested whether weekly social groups could help older veterans with depression feel less lonely and improve their mood. 18 veterans joined the groups and filled out questionnaires about their symptoms and social connections. The goal was to see if the program works and …

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested whether a brain wave measurement called mismatch negativity (MMN) can help match veterans with mental illness to the most effective cognitive training program. 100 veterans with conditions like schizophrenia, PTSD, or mood disorders participated. The goal was to…

This study looked at how brain signals and thinking skills affect recovery from cocaine addiction in 63 veterans. Participants either received usual care or a prize-based program that rewards cocaine-free urine tests. Researchers measured brain activity and thinking before and du…

This study tested a new approach called DREAM, where Veterans at risk for sleep apnea could go straight to home sleep testing without an initial in-person clinic visit. Over 6,500 Veterans took part to see if this speeds up diagnosis and treatment. The goal is to make sleep apnea…

This study tested a web-based decision support tool called MyPath for women veterans aged 18-44. The tool helps them think about pregnancy goals and birth control before a VA primary care visit. Half of the 465 participants got a link to the tool before their appointment; the oth…

This study tested a way to return genetic test results to 112 veterans who had a gene variant linked to heart disease. Participants received their results and genetic counseling. Researchers then checked if their cholesterol levels improved after 6 months. The goal was to see if …

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if thi…

This pilot study tested an 8-week group program called RBSTE designed to help Veterans of Color build coping skills and empowerment in response to race-based stress. Thirty-seven veterans participated to see if the program is feasible and acceptable. The goal is to gather informa…

This study tested whether having frontline mental health staff use computer simulations to plan clinic changes can improve access to evidence-based care for veterans with PTSD, depression, or opioid use disorder. Researchers compared this simulation approach to usual quality impr…

This study tested whether regular support calls can help veterans who are not ready to quit smoking to eventually stop. Over 500 veterans received either four calls a year (enhanced care) or one call a year (standard care). The goal was to see if more calls led to more quit attem…

This study looked at whether a 12-week indoor cycling program could improve brain blood flow and function in 37 older veterans (ages 65-80) who did not exercise regularly. Researchers measured brain health before and after the exercise program using MRI scans. The goal was to lea…

This study looked at whether a program that helps doctors and patients make decisions together can improve care for veterans with rheumatoid arthritis. About 900 veterans took part across multiple VA clinics. The goal was to see if this approach lowers disease activity and helps …

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study tested a self-help tool called EMBER to see if it helps veterans with obesity use VA weight management programs more often. 470 veterans were randomly assigned to receive EMBER or just a list of programs. Researchers checked program use after 2 and 6 months via records…

This study tested a new program called the Relational Playbook, which gives nurse managers tools and coaching to create a more supportive work environment for their cardiology teams. Ten VA heart clinic staff members took part to see if the program was easy to use and helpful. Th…

This study looked at different methods for screening male veterans over 65 for osteoporosis, a condition that weakens bones and raises fracture risk. Over 3,500 veterans took part, and researchers compared how well each screening approach worked. The goal was to find the most eff…

This study looked at how often and in what way word-retrieval therapy should be given to stroke survivors with aphasia (trouble finding words). Researchers tested 32 Veterans to see which treatment schedule works best and what factors predict improvement. The goal is to personali…

This study looked at whether it's possible and acceptable to screen for hearing loss in the emergency department (ED). Researchers worked with 133 veterans who had mild hearing trouble to see if using a hearing device helped them communicate with doctors and understand discharge …

This study looked at how mild traumatic brain injury (mTBI) affects self-regulation—the ability to plan, focus, and manage emotions. Researchers used brain scans (fMRI) and tested a medication called tolcapone to see if it could improve memory and self-control in 55 veterans with…

This study tested a program called Recovery Bridge, where trained peer specialists help people leaving psychiatric hospital adjust to life back in the community. The goal was to see if the program is practical and acceptable, and to explore whether it reduces hospital readmission…

This study tested whether a coaching program for primary care doctors at one VA clinic could improve care for veterans with unhealthy alcohol use. The program aimed to help doctors offer more counseling, medications, and referrals to specialty treatment. Researchers tracked chang…

This study tested a 12-week program where trained peer leaders guided older veterans with mobility issues in group exercise sessions twice a week and healthy eating discussions once a week. The goal was to see if this approach could improve diet quality and physical fitness. Thir…

This study tested a career counseling program called Purposeful Pathways for veterans with psychiatric disorders who were struggling to find or keep jobs. The program involved up to 12 weekly sessions focused on career goals, job searching, and building confidence. Researchers wa…

This study tested whether simple nudges—like an alert in a doctor's daily task list or an email comparing their prescribing habits to peers—could increase the use of two types of heart failure medications (SGLT2 inhibitors and MRAs) that are proven to save lives but are often und…

This study looked at how to help more veterans with opioid use disorder get effective medication. Researchers combined six pilot projects across 63 VA sites to find the best ways to increase access to these treatments. The goal was to see if a structured support program for healt…

This completed VA study tested whether teaching mindfulness during hand hygiene could improve well-being and reduce burnout in 343 nurses and physicians. Participants in the intervention group received mindfulness education, group discussions, and an optional app, and were encour…

This study tested whether brain wave patterns during sleep can detect PTSD and measure how severe it is. Researchers studied 26 veterans with PTSD using EEG recordings. The goal is to create an objective test that goes beyond questionnaires and doctor assessments.

This completed study looked at how veterans with HIV use the VA's online health portal, My HealtheVet (MHV). Researchers reviewed medical records and interviewed 123 veterans and their providers to understand how MHV helps manage HIV. The goal was to create and test a new interve…

This study looked at how to help VA clinics refer more veterans to a suicide prevention telehealth program called SP 2.0. Researchers used coaching and team-based quality improvement methods. Only 4 clinics participated, so the results are very limited and not generalizable.

This study looked at what makes it easier or harder for veteran stroke survivors to do arm and hand exercises at home. Researchers gave surveys about mood, confidence, and sleep, then used a wearable tracker to measure exercise. The goal is to find ways to help people stick with …

This study looked at whether offering PTSD therapy several times a week (massed) instead of once a week helps veterans complete their treatment. 30 veterans took part, and researchers measured how many finished therapy, how satisfied they were, and changes in PTSD symptoms. The g…

This study tested whether taking calcium before exercise can help bones get stronger from workouts. Exercise normally causes a drop in blood calcium, which may limit bone benefits. Researchers gave 18 Veterans calcium or a placebo before exercise to see if it improved bone-buildi…

This study tested whether a smartphone app could help veterans with serious mental illnesses like schizophrenia and bipolar disorder track their own symptoms. 87 veterans used the app to monitor their activity, sleep, and social interactions. The goal was to see if this data coul…

This study tested a new hybrid pump that creates a vacuum to hold a prosthetic limb securely in place. Twelve people with amputations walked in a lab to see if the pump worked well. The goal was to improve comfort and mobility compared to traditional suspension methods.

This study tested a special prosthetic foot that can twist as you walk, just like a real ankle does. Fourteen people with a below-knee amputation tried different twist settings while walking in straight lines and circles. The goal was to find the setting that feels best and puts …

This study looked at whether a gentle, non-invasive brain stimulation technique can help older adults (65+) learn and remember new walking skills more easily. Researchers used brain scans to understand how the brain changes with practice. The goal is to make physical therapy fast…

This study looked at how sharing information about what matters to older Veterans with chronic pain—like how they store medications or get help from family—can improve their care. Researchers talked with 230 Veterans aged 65 and older, their caregivers, and doctors to design a co…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness (like schizophrenia or major depression with psychosis) work more closely with their doctors in making treatment decisions. The program involved eight wee…

This study looked at a telemedicine program called TOP that helps rural veterans with PTSD get care without traveling far. Over 500 veterans took part. The goal was to see which method of rolling out the program worked better to reach more patients and improve PTSD symptoms.

This study tested a new way to assess and train balance using a reaching task. Seven people (healthy adults and stroke survivors) participated. The goal was to see if this method can help improve balance and prevent falls.

This study followed 368 people with end-stage ankle arthritis who chose to have surgery. Researchers used surveys, step counts, and walking tests to measure how well they functioned after surgery. The goal was to compare different surgical treatments and understand long-term outc…

This study monitored the sleep of 48 Veterans with PTSD and frequent trauma nightmares using special mattress sensors in their own homes. The goal was to learn how nightmares affect sleep quality and heart activity, and how these change with a cognitive-behavioral treatment. Resu…

This study looked at whether balance and walking problems in people with Parkinson's disease are caused by changes in the inner ear (vestibular system) rather than just a lack of dopamine in the brain. 60 participants with Parkinson's underwent balance tests and brain scans. The …

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with PTSD. Researchers measured cravings, heart rate, and drinking patterns, and also examined how these effects change across the menstrual cycle. The goal was to be…

This study looked at how to help busy doctors at VA clinics adopt better treatments for three common issues: reducing risky medications in older adults, using blood thinners more safely, and offering talk therapy for insomnia instead of sleep pills. Researchers compared two diffe…

This study tested whether a gentle brain stimulation technique called tDCS could make cognitive training more effective for veterans with alcohol use disorder. Forty-five veterans participated, receiving either real or fake tDCS while doing brain exercises. The goal was to see if…

This study tested different public messages to encourage veterans who recently left the military and are thinking about suicide to seek mental health care. Researchers enrolled 355 veterans who had suicidal thoughts but were not currently in treatment. They measured whether the m…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study looked at how to best help emergency room doctors avoid prescribing potentially harmful medications to older veterans. Researchers compared two methods: giving doctors regular reports on their prescribing habits (passive feedback) versus having them actively discuss an…

This study tested a new way to deliver mental health care to rural veterans by combining in-person primary care with telemedicine support. About 318 veterans with depression, alcohol use problems, or PTSD took part. The goal was to see if this blended approach improves mental hea…

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…

This study looked at whether veterans with traumatic brain injury (TBI) and insomnia can reliably measure their internal body clock at home. Thirty-one veterans wore a wrist device for a week and collected saliva samples to track melatonin levels. The goal was to see if these hom…

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard an…

This study tested a special training platform designed to help older veterans and those with disabilities improve their balance and reduce the risk of falling. Researchers enrolled 62 participants and used reaching tasks at the limits of balance to measure and train stability. Th…

This study followed 416 veterans with low back pain to see which physical activities cause short-term pain flares and which help long-term recovery. Participants reported their pain and disability over time. The goal was to identify helpful and harmful activities, not to test a t…

This study looked at nearly 1,000 transgender veterans to understand what helps or hinders them from getting gender-affirming treatments like hormone therapy and mental health care. Researchers surveyed veterans to find out which treatments they received and where, and how this a…

This study looked at whether a program called MISSION-CJ can help homeless veterans who have both substance use and mental health problems stay out of trouble with the law. 134 veterans took part, and researchers tracked arrests, substance use, housing, and employment. The goal w…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study followed 227 veterans with swallowing problems (dysphagia) for 8 weeks to see if measuring throat pressure during swallowing can predict who will improve with therapy. Participants did standard strengthening exercises, and researchers compared their pressure readings, …

This pilot study tested whether health coaching can help veterans who recently left the military adjust to civilian life and reduce suicide risk. Researchers worked with 95 veterans to see if the program was practical and well-received. The goal was to prepare for a larger future…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study looked at whether adding family members to cognitive behavioral therapy (CBT) helps veterans with anxiety disorders. 48 veterans and their family members tried a new program called AF-CBT. The goal was to see if the program was acceptable and practical, not yet to prov…

This study tested a simple, portable virtual reality system to measure balance in veterans with cervical spondylotic myelopathy (CSM), a spinal cord condition that affects walking and stability. Eight participants completed balance tasks under different visual and surface conditi…

This study looked at whether diuretics (water pills) can help reduce extra fluid in the body and improve heart health in people with early chronic kidney disease. Researchers measured changes in heart stress markers, fatigue, and depression after 4 weeks of treatment. The goal wa…

This study looked at how complementary health approaches like acupuncture, massage, and yoga affect chronic pain in over 3,600 veterans. Researchers compared the effects of practitioner-delivered therapies alone versus combining them with self-care practices. The goal was to unde…

This small study tested whether real-time neurofeedback—a technique where people learn to control their own brainwaves—could improve memory-related brain activity in older veterans with mild cognitive impairment. Four veterans aged 60 and older participated. The goal was to see i…

This study looked at whether measuring the skin's electrical activity can warn of agitation or aggressive behavior in people with dementia. 21 patients from a dementia unit took part. The goal was to see if a warning signal appears before an outburst, which could help caregivers …

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This study looked at whether sending caring postcards from fellow Veterans can reduce loneliness and improve mental health in older Veterans. Nearly 1,000 Veterans aged 50 and older who had missed VA appointments took part. They received up to 10 postcards and completed surveys t…