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Brain wave therapy could help veterans with blast injuries

NCT ID NCT03836976

Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if this approach could help identify and treat brain circuit problems caused by blast exposure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Auditory gamma sensory stimulation (40 Hz amplitude-modulated tone)
What this could lead to
If successful, this could lead to new ways to detect and treat brain injury from blasts in veterans, helping their recovery.
What could go wrong
This is a very small early study with only 5 participants, so results may not apply broadly. It is exploratory and may not lead to a proven treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

5 people

The number who actually took part.

Started

Dec 2019

Finished

Jun 2026

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Research participants will be 50 veterans * Ages 18-65 years * Have experienced blast exposure * Recruited from the VA Translational Research Center for TBI and Stress Disorders (TRACTS) at the VA Boston Healthcare System (VABHS) * Half of the participants will have experienced blast exposure from a Close distance (\<10 m) * Half of the participants will have experienced blast exposure from a Far distance (\>10 m) * These groups will be matched on age and female/male ratio Exclusion Criteria: Initial exclusion criteria for TRACTS are: * History of neurological illness * Huntington's * Parkinson's * dementia, etc * History of seizure disorders unrelated to head injury * Current diagnosis of schizophrenia, bipolar, or other psychotic disorder * Self-reported severe depression or anxiety requiring hospitalization overnight, or current active homicidal and/or suicidal ideation with intent requiring crisis intervention * Cognitive disorder due to general medical condition other than TBI * Unstable psychological diagnosis (suspected psychotic or personality disorder) that would interfere with accurate data collection, determined by consensus of at least three doctoral-level psychologists. Additional exclusion criteria for participants in the present project will be: * Current alcohol or drug dependence, or abuse within the last 6 months (DSM-IV criteria) * Hearing impairments as assessed by audiometry

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Conditions

The condition(s) this trial relates to.

Brain Concussion traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MTBI

Contacts and locations

Locations

  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

    Boston, Massachusetts, 02130-4817, United States

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