Can a magnetic helmet curb alcohol cravings in veterans?
NCT ID NCT03191266
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could help veterans with alcohol use disorder stay sober for six months. Forty-nine veterans who were already in treatment received either real or sham rTMS. Researchers then tracked their alcohol use monthly to see if the stimulation improved abstinence rates.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS)
- What this could lead to
- If it works, this could offer a non-invasive, safe treatment option to help veterans with alcohol use disorder maintain long-term sobriety.
- What could go wrong
- This was a small, early-stage study with only 49 participants, so results may not apply broadly. The treatment may not be more effective than a placebo, and long-term benefits are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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49 people
The number who actually took part.
- Started
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Apr 2018
- Finished
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Jun 2024
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The study will be open to male and females, regardless of race and ethnic origin, who are in active treatment for an alcohol use disorder (AUD). * Meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition criteria for AUD, and alcohol is self-identified as primary substance of misuse. * Actively in treatment at VA Palo Alto HCS Addiction Treatment Service, and able to read, verbalize understanding, and voluntarily sign the Informed Consent Form prior to participation in study procedures. * Participants will be accepted if taking medications specifically for the treatment of MDD, cigarette smoking, or for other psychiatric conditions. * as long as the medications are not documented to lower seizure threshold * must be stable on any psychotropic medication for at least 1 month prior to enrollment * it would be clinically contraindicated to require participants to discontinue such medications for research. * Participants will be abstinent from alcohol and non-prescribed substances for at least 7 consecutive days prior to active or sham rTMS and no participant demonstrates active acute withdrawal symptoms. Exclusion Criteria: Psychiatric: * History of Schizophrenia Spectrum Disorders * Bipolar Disorders * A current substance use disorder that exceeds the severity of the AUD * based on DSM-5 diagnostic criteria * Current use of an FDA approved medication for treatment of AUD, i.e.: * disulfiram * acamprosate * naltrexone * Active current suicidal intent or plan * patients with a previous clinical flag for risk for suicide will be required to have an established safety plan involving their primary psychiatrist and the treatment team before entering the clinical trial * Any form of previous rTMS or electroconvulsive treatment Biomedical: * Including but not limited to uncontrolled thyroid disease * Unstable congestive heart failure * Angina * Other severe cardiac illness as defined by treatment regimen changes in the prior 3 months * Cerebrovascular accident * Cancer if \< 1 year since end of treatment * Unstable diabetes * COPD requiring oxygen supplementation * Alzheimer's disease * Parkinson's disease * Any biomedical implants with ferromagnetic content * Neurostimulation devices * Cardiac pacemakers or any magnetic resonance contraindications * Traumatic brain injury with self-reported or observed loss of consciousness \> 30 minutes * Any primary or traumatically induced seizure disorder General: * Lack of fluency in English * Wechsler Adult Reading Test below the 7th percentile, i.e.: * moderate or greater impairment in estimated general intelligence * Females who are pregnant or actively attempting pregnancy * conservative exclusion for magnetic resonance research * Current use of any medication or substance that is documented to lower seizure threshold or has been identified as a contraindication for rTMS treatment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, 94304-1207, United States
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Other studies related to the condition(s) this trial covers.
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