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New hope for veterans: simple therapy may lift depression after brain injury

NCT ID NCT04976621

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was practical and helpful in reducing depression and improving community life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

46 people

The number who actually took part.

Started

Feb 2022

Finished

Jun 2024

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veteran enrolled in the outpatient Rehabilitation Medicine Service at the Corporal Michael J. Crescenz VA Medical Center * Age of 21 years or older * Meet professional criteria for mild or moderate TBI * Confirmation of TBI diagnosis * Have a CES-D score at or above 16 at both the Telephone Screen and Baseline * Those taking antidepressants or other medications affecting mood or behavior must have been using these for at least three months, to allow for stabilization. * Those in psychotherapy can participate if therapy has been ongoing for three months or longer. * Veterans report current TBI-related symptoms on the Telephone Screen. * Speak English Exclusion Criteria: * A diagnosis of severe TBI * Psychosis * Aphasia * History of bipolar disorder * Presence of suicidal ideation with affirmative response on item 9 of the PHQ-9 * History of severe physical aggressiveness, judged by the clinical team * Currently receiving Cognitive Behavioral Therapy for depression * Dementia (determined on case-by-case basis based on physician diagnosis and participant's difficulty understanding interview questions)

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic Depression depressive disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic brain injury

Contacts and locations

Locations

  • Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Philadelphia, Pennsylvania, 19104-4551, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.