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Sleep brain waves may reveal PTSD in veterans

NCT ID NCT04209387

Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether brain wave patterns during sleep can detect PTSD and measure how severe it is. Researchers studied 26 veterans with PTSD using EEG recordings. The goal is to create an objective test that goes beyond questionnaires and doctor assessments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to an objective brain-based test to diagnose PTSD and track treatment progress, reducing reliance on self-reports.
What could go wrong
This is a small, completed study with only 26 veterans. The markers need much larger validation before they can be used in clinics. They may not work for all PTSD cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

26 people

The number who actually took part.

Started

Feb 2021

Finished

Dec 2024

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Veterans who have been previously deployed and meet diagnostic criteria for PTSD. Prior traumatic experience(s) does not have to be direct combat (e.g. may include search and rescue of combat operations). Persons previously treated for PTSD will be eligible so long as current diagnostic criteria are present.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veterans who have been previously deployed and meet diagnostic criteria for PTSD. Prior traumatic experience(s) does not have to be direct combat (e.g. may include search and rescue of combat operations). Persons previously treated for PTSD will be eligible so long as current diagnostic criteria are present. Specific inclusion criteria are as follows: * Current (past month) diagnosis of PTSD as determined from the 30-item CAPS (score \>45). * History of deployment and combat-related exposure stated as the principal reason for seeking treatment (based on self-report). * Ability to read and speak English to complete surveys and participate in therapy. * Explicit denial of suicidal or homicidal ideation or intent, which will be corroborated by reviewing the patient chart. Exclusion Criteria: * Brain injury prohibiting speech, writing, and purposeful actions. * Identified to have current suicidal or homicidal ideation (immediate referral to a crisis center/hospital). * Major confounding psychiatric disorder; i.e. assessment indicates presence of: * Major mental health disorder that involves psychosis * Otherwise in the state of psychological crisis (appropriate referral to occur) * Current or recent (within 1 month of study entry) DSM-5 substance use disorder * Individuals who are taking either illicit or prescribed Rx that could interfere with EEG, including benzodiazepines and certain mood stabilizers (e.g., Lithium)

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PTSD

Contacts and locations

Locations

  • VA Bedford HealthCare System, Bedford, MA

    Bedford, Massachusetts, 01730-1114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.