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Exercise may turn back the clock for HIV veterans

NCT ID NCT04103593

Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life, not to cure HIV.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

89 people

The number who actually took part.

Started

Mar 2020

Finished

Sep 2024

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Veteran living with HIV and under care at VAMC * 50 years of age and older * Stable antiretroviral therapy (same ARV medications within 3 months) * At least one HIV-1 PCR \< 20 c/ml (viral load) within prior 6 months Exclusion Criteria: * History of AIDS defining illnesses (within 6 months; CDC Criteria) * Myocardial infarction (within 3 months) * Exertional or unstable angina (current chest pain that limits activity) * Severe congestive heart failure (EF \< 20% in last year or NYHA Classification III or IV) * Uncontrolled hypertension (SBP \>180 \&/or DBP \> 110 mm Hg) * Therapy with beta blockers or non-dihydropyridine calcium channel blocker (within 1 month) * Screening EKG with ischemia, complex arrhythmia, or high-grade block (per Minnesota Code) * Poorly controlled DM within prior 1 month (FBS\>180 mg/dl, RBS \> 299 mg/dl, or HbA1C \> 10) * Receiving treatment for cancer except skin cancer (within 3 months) * Peripheral vascular disease with claudication * Severe arthritis limiting ambulation * Neurologic disease limiting ambulation (requiring assist device) * End stage liver disease (decompensated liver disease) * Chronic renal failure (requiring dialysis) * Severe pulmonary disease (home O2, admission for dyspnea or pneumonia within 1 month) * Use of systemic steroids (testosterone or glucocorticoids) or growth hormone (within 6 months) * Dementia (based on Evaluation to Consent) * Signs or symptoms of any medical comorbidity that would preclude exercise testing or training * Exercise on routine basis (structured aerobic exercise \> 3 times per week) within 1 month * Past medical history of COPD or emphysema AND mMRC score =4

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV infection

Contacts and locations

Locations

  • Atlanta VA Medical and Rehab Center, Decatur, GA

    Decatur, Georgia, 30033, United States

  • Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

    Baltimore, Maryland, 21201, United States

  • Salem VA Medical Center, Salem, VA

    Salem, Virginia, 24153-6404, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.