HIV INFECTION

This early-stage study tests a new experimental drug, MK-4646, in 28 people with HIV-1 who have never taken HIV medication. The main goals are to see if the drug is safe and tolerable, and to measure how much it lowers the amount of virus in the blood. Participants will take the …

This study compares heart transplants from HIV-positive and HIV-negative donors in 50 HIV-positive patients with advanced heart failure. Participants receive whichever donor heart becomes available first, and researchers track survival, graft function, and serious side effects fo…

This study tests whether giving very early, intensive anti-HIV drugs, with or without an added antibody, can help infants living with HIV achieve remission — meaning the virus stays undetectable even after stopping treatment. Researchers will enroll over 1,100 mothers and their b…

This study tests whether taking 75 mg of zinc daily can improve immune function in people with HIV who still have low CD4 counts despite effective antiretroviral therapy. Researchers will randomly assign 120 participants to receive zinc supplements or continue their usual care. T…

This phase 1 trial is testing a CAR-T cell therapy (axicabtagene ciloleucel) in 20 adults with HIV and aggressive B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to recognize and attack cancer c…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and achieve undetectable viral loads. About 716 men will be randomly assigned to different le…

This study tests whether a smartphone app designed for people with HIV can help them quit smoking when they also get a lung cancer screening scan. About 100 participants will use the app and have a low-dose CT scan. The goal is to see if this approach is practical and helps peopl…

This study is checking if a new self-test for HIV and syphilis is accurate and easy for people to use at home. About 900 adults in Canada will try the test and compare results with standard lab tests. The goal is to make testing more accessible, especially for people experiencing…

This study tests whether giving HIV prevention medication (PrEP) on a mobile medical van is a good option for people who inject drugs or are sexually active. Researchers will enroll 20 adults and track how many start and stay on PrEP, and how many remain HIV-free over 6 months. T…

This study looks at immune cells in the gut, spinal fluid, lymph nodes, and blood of 232 adults in Thailand, both with and without HIV. The goal is to understand how HIV changes the immune system in different body compartments. Participants provide samples for analysis, and no ne…

This study follows 450 HIV patients who can naturally control the virus without taking antiretroviral therapy. Researchers want to understand how their immune systems keep the virus in check and why some eventually lose control. The goal is to learn more about HIV control and imm…

This study tests whether setting up special HIV teams in hospitals can help find undiagnosed HIV in patients who have conditions linked to HIV. About 5,200 patients across ten European countries will be included. The teams will review medical records, remind doctors to offer HIV …