HIV INFECTION

This study tested four different combinations of experimental HIV vaccines in healthy volunteers to see which approach was safest and best at triggering an immune response. Ninety-two participants at low risk of HIV infection received different sequences of vaccine shots over sev…

This study tested whether people who received an experimental antibody (VRC01) before getting HIV could better control the virus without needing daily medication. Thirteen participants who had been taking HIV drugs for at least a year temporarily stopped their medication under ve…

This study tested if people with well-controlled HIV could safely switch from their current daily medications to a new, single once-daily pill containing two drugs, doravirine and islatravir. It involved 672 participants whose virus was already suppressed. The main goal was to se…

This study tested if people with well-controlled HIV could safely switch from a standard three-drug daily pill to a new two-drug daily pill. Researchers compared the new combination (doravirine/islatravir) against continuing the original treatment to see if it kept the virus supp…

This study tested a new dose of three proven HIV medicines (dolutegravir, emtricitabine, and tenofovir alafenamide) in children under 10 years old in Africa. The goal was to find the right dose to create a single, easy-to-take tablet that works for all children, just like adults.…

This study tested whether a 12-week, high-intensity exercise program delivered by video could slow down the accelerated aging process seen in older Veterans living with HIV. Researchers enrolled 89 Veterans over age 50 with stable HIV to see if the no-equipment circuit training c…

This study tested whether having a personal guide, called a systems navigator, could help men in Malawi stick with their HIV prevention medication (PrEP) for six months. The study involved 199 heterosexual men who were already seeking care for other sexually transmitted infection…

This study tested whether the HPV vaccine could help prevent high-grade cervical lesions from developing or returning in women living with HIV. 536 HIV-positive women who also had HPV received either the actual vaccine or a placebo (saltwater shot) after their cervical lesions we…

This study is observing children who started HIV medication within weeks of birth to understand their long-term health, immune system, and virus levels. About 250 children will be followed for up to seven years with regular check-ups and sample collection. The goal is to gather d…

This study aimed to understand how the body's own immune system might be involved in causing or worsening pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers compared blood samples from over 600 people, including patients wi…

This study aimed to understand if HIV infection causes hidden problems with how the kidneys process water, even when standard blood and urine tests appear normal. Researchers compared 30 adults with HIV to people without HIV using a special kidney function test. The goal was to g…