New combo therapy shows promise in reducing veteran suicides
NCT ID NCT03952468
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed study tested a new approach to reduce suicide behavior in high-risk veterans by combining transcranial magnetic stimulation (TMS) with brief cognitive behavioral therapy (BCBT). Fifty-five veterans who had recently attempted suicide or had strong suicidal thoughts took part. The goal was to see if this combination could lower suicide attempts and related behaviors more than existing treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcranial Magnetic Stimulation (TMS) and Brief Cognitive Behavioral Therapy (BCBT)
- What this could lead to
- If successful, this combination therapy could offer a new, practical treatment to reduce suicide behavior in high-risk veterans.
- What could go wrong
- This was a small, early-stage study with only 55 participants, so results may not apply broadly. The effects need confirmation in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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55 people
The number who actually took part.
- Started
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Nov 2019
- Finished
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Apr 2024
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: -Suicide attempt or suicidal ideation with intent to make a suicide attempt within 48 hours of hospitalization as indicated on the hospital chart and confirmed by administration of the C-SSRS. Exclusion Criteria: * Primary psychotic disorder * Bipolar disorder * Cognitive impairment which would interfere with adequate participation in the project (MMSE \< 20). * For safety, participants must meet established screening criteria safety during MRI, which is implemented as a conservative measure given the application of TMS in this population, since MRI involves magnetic fields at similar intensity to those emitted from the stimulation coil. These measures require a patient not having the following (unless MRI-safe): * Cardiac pacemaker * Implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord. * TMS-specific exclusions are: * pregnancy/lactation, or planning to become pregnant during the study * lifetime history of moderate or severe traumatic brain injury (TBI) * Current unstable medical conditions * Current (or past if appropriate) significant neurological disorder * Lifetime history seizure disorder * Primary or secondary CNS tumors * Stroke * Cerebral aneurysm. * Other exclusions are conditions that would like to be worsened by TMS, such as bipolar disorder * Place Veterans at greater risk of seizures from TMS, such as severe and uncontrolled substance use disorder * Inability to participate in CBT * Other conditions or circumstance that, in the opinion of the investigator team, has the potential to prevent study completion and/or to have a confounding effect on outcome assessments
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Providence VA Medical Center, Providence, RI
Providence, Rhode Island, 02908-4734, United States
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Other studies related to the condition(s) this trial covers.
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