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New combo therapy shows promise in reducing veteran suicides

NCT ID NCT03952468

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed study tested a new approach to reduce suicide behavior in high-risk veterans by combining transcranial magnetic stimulation (TMS) with brief cognitive behavioral therapy (BCBT). Fifty-five veterans who had recently attempted suicide or had strong suicidal thoughts took part. The goal was to see if this combination could lower suicide attempts and related behaviors more than existing treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial Magnetic Stimulation (TMS) and Brief Cognitive Behavioral Therapy (BCBT)
What this could lead to
If successful, this combination therapy could offer a new, practical treatment to reduce suicide behavior in high-risk veterans.
What could go wrong
This was a small, early-stage study with only 55 participants, so results may not apply broadly. The effects need confirmation in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

55 people

The number who actually took part.

Started

Nov 2019

Finished

Apr 2024

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: -Suicide attempt or suicidal ideation with intent to make a suicide attempt within 48 hours of hospitalization as indicated on the hospital chart and confirmed by administration of the C-SSRS. Exclusion Criteria: * Primary psychotic disorder * Bipolar disorder * Cognitive impairment which would interfere with adequate participation in the project (MMSE \< 20). * For safety, participants must meet established screening criteria safety during MRI, which is implemented as a conservative measure given the application of TMS in this population, since MRI involves magnetic fields at similar intensity to those emitted from the stimulation coil. These measures require a patient not having the following (unless MRI-safe): * Cardiac pacemaker * Implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord. * TMS-specific exclusions are: * pregnancy/lactation, or planning to become pregnant during the study * lifetime history of moderate or severe traumatic brain injury (TBI) * Current unstable medical conditions * Current (or past if appropriate) significant neurological disorder * Lifetime history seizure disorder * Primary or secondary CNS tumors * Stroke * Cerebral aneurysm. * Other exclusions are conditions that would like to be worsened by TMS, such as bipolar disorder * Place Veterans at greater risk of seizures from TMS, such as severe and uncontrolled substance use disorder * Inability to participate in CBT * Other conditions or circumstance that, in the opinion of the investigator team, has the potential to prevent study completion and/or to have a confounding effect on outcome assessments

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Conditions

The condition(s) this trial relates to.

Suicide Suicide Prevention

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Providence VA Medical Center, Providence, RI

    Providence, Rhode Island, 02908-4734, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.