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New combo treatment aims to help veterans quit smoking and manage PTSD

NCT ID NCT03978442

Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tested a treatment called CPT-SMART that combines PTSD therapy, smoking cessation counseling, medication, and financial incentives to help veterans quit smoking. 120 veteran smokers with PTSD were randomly assigned to either the full program or a control group. The goal was to see if this combined approach leads to higher quit rates and better engagement in treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupropion (Zyban)
What this could lead to
If successful, this approach could provide an effective way to help veterans with PTSD quit smoking, reducing smoking-related illness and death.
What could go wrong
This is a completed Phase 4 trial with 120 participants, so results are available but may not apply to all smokers with PTSD. The intervention is complex and may not be widely adopted.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

115 people

The number who actually took part.

Started

Nov 2019

Finished

Oct 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Is Veteran * Is between the ages of 18 and 80 * Smokes ten or more cigarettes per day for the past year * Has been smoking for at least the past year * Meets criteria for current PTSD * Speaks and writes English * Is willing to attempt smoking cessation and trauma-focused psychotherapy Exclusion Criteria: * Has had myocardial infarction in the past 6 months * Uses other forms of nicotine that he/she is unwilling to stop * Is pregnant * Has a primary psychotic disorder * Has a current substance use disorder other than tobacco use disorder * Has a contraindication to bupropion use with no medical clearance to use it * Is unwilling to use bupropion * Is receiving other behavioral smoking counseling or trauma-focused therapy or plans to do so during the study period * Is currently imprisoned or in psychiatric hospitalization

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Conditions

The condition(s) this trial relates to.

nicotine dependence post-traumatic stress disorder Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Smoking Stress disorders, post-traumatic

Contacts and locations

Locations

  • Durham VA Medical Center, Durham, NC

    Durham, North Carolina, 27705-3875, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.