Magnetic pulses to the brain: a new hope for veterans with PTSD?
NCT ID NCT04207346
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic fields to stimulate specific brain areas — can improve daily functioning in veterans with PTSD. Researchers compared real TMS to a sham (fake) treatment in 59 veterans. The goal was to see if TMS could reduce PTSD symptoms and help veterans get back to normal activities.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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59 people
The number who actually took part.
- Started
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Dec 2020
- Finished
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Sep 2025
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age between 19 and 70 2. Moderate to severe PTSD as determined by the CAPS within 7 days of randomization. 3. Agree to have CAPS audio-recorded. 4. Ability to obtain a Motor Threshold using the TMS device during screening. 5. Patient eligible for VA healthcare. 6. If female with childbearing potential, use of acceptable method of birth control (i.e., use of contraceptives, abstinence). 7. Able to read, understand, and sign the informed consent document. Exclusion Criteria: 1. Pregnant or lactating woman. 2. Current use of clozapine (any dose) or bupropion (more than 300mg per day). 3. Cardiac pacemaker or implantable defibrillator. 4. Presence of any metal object in the head, including cochlear implants, but excluding dental work in the mouth. 5. Significant central nervous system disorder (stroke, brain mass, epilepsy). 6. Seizure in past one year. 7. Current psychosis or mania. 8. Prior use of TMS. 9. Significant suicidal ideation. 10. Unstable medical conditions. 11. Current alcohol or substance use disorder (except nicotine) that interferes with the patient's ability to participate. 12. CPT or PE for PTSD in the past 2 months. 13. Changes in Fluoxetine, Paroxetine, Sertraline, or Venlafaxine in the past 2 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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White River Junction VA Medical Center, White River Junction, VT
White River Junction, Vermont, 05001-3833, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a therapist on a screen ease both trauma and pain?
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- Can six short writing sessions ease PTSD in underserved patients?
- Can a psychedelic compound help veterans and first responders with PTSD and alcohol use disorder?