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Brain's food pleasure linked to insulin resistance in obesity study

NCT ID NCT02241603

Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard and find new ways to treat obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

37 people

The number who actually took part.

Started

Nov 2014

Finished

Jul 2020

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 25-60yoa, inclusive. * BMI 30.0 and 45.0 kg/m2, inclusive. * Normal visual acuity with correction. * Able to travel regularly to the St. Louis VA and Washington University for research visits. * Completed signed informed consent form. Exclusion Criteria: * Current or history of significant psychiatric disease, including Binge Eating Disorder (BED). * Current or history of significant substance abuse or extended use of tobacco. * Contraindications for MRI (e.g., pregnancy, claustrophobia, pacemaker, circumference \> 54 inches, weight \> 400 lbs, etc.); * Significant cardiovascular, pulmonary, renal, liver, neurologic, or metabolic disease. * Diabetes mellitus. * Significant anemia. * Treatment with a medication the affects insulin sensitivity. * Treatment with centrally acting medications. * Frequent shift work. * Significant in-mobility or unable to lay on back still for 1 hour. * History of bariatric surgery. * Food allergies/ intolerance that would prevent completing study. * Symptoms concerning for untreated active mental health disease

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • St. Louis VA Medical Center John Cochran Division, St. Louis, MO

    St Louis, Missouri, 63106, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.