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Mind over phantom pain: brain training offers Drug-Free hope for amputees

NCT ID NCT05880251

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jul 2023

Finished

Aug 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * An upper (or lower limb) amputation more than 6 months ago, that has produced a moderate to severe hand/arm (or foot/leg) phantom limb pain, * Male or female age 18 years or older, * Medical clearance to participate, * Reasonable expectation that ongoing medications, if any, will be maintained without change for at least 4 months from the start of the study, * Able to provide informed consent and to understand the study instructions, * Able to participate in the specific study procedures. Exclusion Criteria: * Presence of other medically unstable and/or infectious condition (e.g., uncontrolled diabetes with recent weight loss, diabetic coma, frequent insulin reactions), * A cardiac condition (e.g., history of myocardial infarction or congestive heart failure), * Cognitive and/or attention difficulties affecting participant's ability to follow study directions, * Known skin disorders or damaged skin at the anticipated at the scalp for EEG recording (e.g., unhealed wounds, broken skin). * Metal implants above the chest

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Lower limb amputation Phantom limb pain after amputation Phantom pain Upper limb amputation

Contacts and locations

Locations

  • Albany VA Medical Center Samuel S. Stratton, Albany, NY

    Albany, New York, 12208-3410, United States

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