Va Office Of Research And Development

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study for veterans with prostate cancer that has returned in a few spots (oligorecurrence) compares standard systemic therapy alone versus standard therapy plus PET-directed local treatment using surgery or radiation. The goal is to see if adding local therapy delays the can…

This study is testing whether empagliflozin (Jardiance), a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. Researchers will enroll 264 veterans and monitor for side effects like infections and changes in kidney function…

This study tests whether a non-invasive device that sends small electrical pulses to the spine, combined with repetitive hand and arm exercises, can improve movement in people with chronic tetraplegia from a cervical spinal cord injury. Researchers will measure changes in muscle …

This phase II trial tests whether adding itraconazole, a common antifungal medication, to standard chemoradiation can improve outcomes for people with resectable esophageal cancer. About 78 participants will receive itraconazole before and after standard treatment, then undergo s…

This study tests a sensory neuroprosthesis—implanted electrodes that send small electrical currents to remaining nerves—to restore sensation of a missing lower limb in people with diabetic peripheral neuropathy and amputation. The 15 participants will also have the option of musc…

This Phase 1 trial tests a custom virtual-reality game that veterans with traumatic brain injury can play at home to improve their near vision. The study enrolls 45 veterans who have trouble focusing on close objects (convergence insufficiency). The main goals are to see if the g…

This phase 2 trial is testing whether a butyrate supplement (Cal-Mag Butyrate) can improve physical function in 120 veterans with Gulf War Illness. The study also looks at effects on fatigue, memory, gut health, and inflammation. Participants take the supplement or a placebo for …

This study tests whether a new combination of two oral drugs, Stenoparib and Temozolomide, works better than the current standard treatment (Lurbinectedin) for people whose small cell lung cancer has returned after initial therapy. Researchers will use a blood test (biomarker) to…

This study tests whether a program of weekly surveys can help veterans with inflammatory bowel disease (IBD) feel better and avoid flare-ups. About 250 veterans at four VA hospitals will either get the usual care or also complete short weekly check-ins for 12 months. The goal is …

This study tests whether a program that combines PTSD treatment with weight management helps Veterans lose more weight and reduce PTSD symptoms better than standard VA care. About 182 Veterans with PTSD and obesity will take part. The program uses counseling and medication to add…

This study tests a computer-based training called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. The training aims to change automatic urges to approach alcohol, helping veterans drink less and recover from alcohol-related problems in work, home, and so…

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study tests whether letting patients manage their own blood pressure medications with guidance from a pharmacist works better than standard care. It includes 160 veterans with chronic kidney disease and high blood pressure. The goal is to see if this approach lowers blood pr…

This study looks at whether genetic testing can help veterans with high cholesterol understand their heart disease risk and feel more comfortable taking statin medications. About 410 veterans aged 40-75 who are not currently on statins will receive genetic test results showing th…

This study tests whether home-based or supervised exercise programs can help older Veterans with chronic kidney disease recover muscle strength and function after being in the hospital. Researchers will measure muscle size, strength, and physical performance in 250 participants. …

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older veterans who have both obesity and signs of muscle loss (sarcopenia). About 50 veterans aged 55 and older will take part. The goal …

This study is testing a surgically implanted device that uses small electrical currents to stimulate nerves and muscles in the trunk and hips. The goal is to help people with spinal cord injury improve their seated posture, balance, breathing, reaching, and ability to push a whee…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study tests whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder drink less heavily. About 330 Veterans will either get medication alone or medication plus the app. The goal is to see if the app makes treatment more effective and ea…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This study looks at whether treating obstructive sleep apnea (OSA) early with a positive airway pressure (PAP) device can improve outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive PAP therapy…

This study tests whether a 6-month online stationary cycling program can improve vision, physical function, and thinking skills in veterans aged 65-89 with intermediate age-related macular degeneration (AMD). Researchers will measure contrast sensitivity, night vision, and visual…

This study tests whether a type of dietary fiber called soluble corn fiber can help older men absorb more calcium and improve bone health. The researchers think the fiber works by changing the bacteria in the gut. Thirty male Veterans aged 60 and older will take the fiber supplem…

This phase 2 trial tests whether adding the targeted drug capivasertib to standard hormone therapy (abiraterone and leuprolide) before prostate removal surgery can shrink or destroy high-risk prostate cancers that have a PTEN gene loss. About 30 men with localized but aggressive …

This study tests whether a dietary fiber supplement called resistant potato starch can improve gut health and quality of life in veterans with Gulf War Illness (GWI). About 52 veterans aged 50-85 with GWI and gut symptoms will take the supplement daily. Researchers will measure c…

This study tests whether MDMA-assisted therapy can help veterans with both PTSD and alcohol use disorder. Eighty veterans will receive either a full dose of MDMA or a low-dose placebo during three therapy sessions. Researchers will measure changes in PTSD symptoms and drinking ha…

This study tests whether exercising more frequently (5 times a week for one month, then three weeks off) is better than exercising once a week with no breaks for people with moderate Parkinson's disease. The exercise is a partnered dance program based on Argentine tango, adapted …

This study looks at 100 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are already taking a BTKi pill (like ibrutinib). Half will keep taking the BTKi alone, while the other half will add a second pill called venetoclax for one year. After …

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming long-term opioid users. About 400 veterans having orthopedic surgery will either receive the program or standard care. The goal is to see if the pr…

This study tests a telemedicine program for 450 Veterans with advanced liver disease. A nurse counselor helps patients understand their illness, discuss what matters most to them, and align treatments—including possible transplant—with their goals. The goal is to improve transpla…

This study tests a combination of two drugs—tulmimetostat (an EZH2 inhibitor) and pembrolizumab (an immunotherapy)—in 66 veterans with advanced non-small cell lung cancer that has worsened after initial treatment. The goal is to see if the combination can shrink tumors or slow ca…

This study tests if a combination of precise radiation and a targeted radioactive drug can control advanced prostate cancer while allowing men to stop standard hormone therapy. About 60 men with a specific type of prostate cancer that no longer responds to hormone treatment will …

This study looks at two common heart medications, metoprolol and carvedilol, in people on dialysis. The goal is to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 adults on hemodialysis will be randomly assigned to one of the two drugs …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for veterans with heart disease who also have other health problems or frailty. The program provides in-person support to help them start and succeed with home-based cardiac rehab. Researchers will comp…

This study looks at two standard treatments for early-stage lung cancer: surgery and a precise type of radiation called stereotactic radiotherapy. About 670 veterans with stage I non-small cell lung cancer will take part. The goal is to see which treatment leads to longer surviva…

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One combines Dialectical Behavior Therapy (DBT) with a PTSD-focused exposure therapy; the other is the current standard VA care. Researchers want to see which better reduces suicidal behav…

This study looks at how well a combined recovery program and home telehealth support help veterans with alcohol or drug problems. About 195 veterans in a VA inpatient unit will take part. The goal is to see if these extra services reduce substance use and improve recovery compare…

This study tests whether metformin, a safe diabetes drug, can improve walking ability and reduce leg pain in 200 veterans with peripheral artery disease (PAD). Participants will take metformin or a placebo for several months. The goal is to see if metformin can reduce inflammatio…

This study is for veterans with stage 3 non-small cell lung cancer that cannot be removed by surgery. It combines chemotherapy, immunotherapy, and radiation to see if this approach helps control the cancer longer and is safe. About 25 participants will receive the treatment, and …

This study tests whether colchicine, an inexpensive anti-inflammatory drug used for gout, can prevent heart attacks, strokes, and death in heart disease patients undergoing major surgery. Researchers will give the drug to 700 veterans before and after their operation. The goal is…

This study looks at 136 Veterans recently hospitalized for suicide risk. Half will get a longer psychotherapy, half a shorter one, to see which works better at reducing suicidal thoughts and actions. Researchers will also use MRI brain scans to track changes over a year and see i…

This study tests a simple, non-invasive technique called remote ischemic preconditioning in 240 adults with heart failure who are scheduled for heart catheterization. The technique involves briefly inflating a blood pressure cuff on the arm to trigger the body's natural defenses,…

This study aims to improve hand hygiene in VA mental health units, where sinks and alcohol-based sanitizers are limited for safety reasons. Researchers will test a tailored hand hygiene bundle, including alcohol-free hand rubs, with about 4 VA staff participants. The goal is to r…

This study tests whether empagliflozin, a diabetes medication, can make arteries less stiff in veterans with obesity. Fifty participants will take either the drug or a placebo for 12 weeks. The main goal is to measure changes in arterial stiffness, a key marker of heart health.

This study tests whether adding a drug that blocks a cancer cell survival process called autophagy can make standard TACE therapy more effective for liver cancer. TACE cuts off the tumor's blood supply, but cancer cells often survive by eating their own parts for energy. The tria…

This study tests a special therapy program for veterans who have been involved with the criminal justice system. The program, called DBT-J, combines mental health support, substance use help, and case management. Researchers want to see if it lowers the risk of future criminal be…

This study tests if a computer-based brain training program can help people who survived a stay in the Intensive Care Unit (ICU) recover their thinking and memory skills. Many ICU survivors experience long-term cognitive problems similar to dementia. The study will involve 160 ad…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This early-stage trial tests a new treatment for a type of bladder cancer that hasn't been helped by the usual therapy (BCG). The treatment uses tiny particles called micelles that carry a chemotherapy drug and are designed to target and kill cancer cells directly in the bladder.…

This study tests whether mild intermittent hypoxia (short, controlled periods of low oxygen) can help prevent dangerous blood pressure swings in people with spinal cord injuries. The treatment aims to improve autonomic function, reducing episodes of high or low blood pressure. Th…

This study tests a new type of nerve stimulation to help Veterans with bladder control problems caused by nerve damage. A small wireless sensor is placed in the bladder to detect when it is filling and trigger stimulation to prevent leakage. The goal is to see if this approach wo…

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have received a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney function and…

This study tests whether a once-monthly injection of buprenorphine helps veterans with opioid use disorder stay in treatment and avoid opioids better than the standard daily under-the-tongue tablet. About 952 veterans will take part for up to a year. The goal is to find a more ef…

This study tests whether a low dose of thyroid hormone (Synthroid) can help Veterans with NASH, a serious liver condition that can lead to liver failure or cancer. About 128 overweight or obese Veterans with NASH will receive either the hormone or a placebo daily for 52 weeks. Th…

This study tests if a smartphone app can detect early knee osteoarthritis by measuring how the knee moves during activities like walking. Researchers will compare the app's results to standard motion capture systems and patient symptoms. The goal is to help doctors diagnose knee …

This study tests a digital tool called CAPP-FIT to help prevent community-acquired pressure injuries in veterans with spinal cord injury. The tool includes a patient survey and a provider report in the electronic health record. Researchers will roll it out at 7 VA clinics and mea…

This study tests whether connecting high-risk veterans leaving the military with trained peer sponsors and mental health services can ease their return to civilian life and reduce suicide risk. About 2,700 veterans from four Army bases will be randomly assigned to usual transitio…

This study tests whether a brief, two-session alcohol counseling program can help Veterans reduce their drinking and prevent intimate partner violence. Researchers will compare this program to alcohol education or standard check-in calls. 300 Veterans who are already in a partner…

This study tests whether a smart mat that measures foot temperature at home can help prevent diabetic foot ulcers in 800 Veterans with diabetes who have had a foot ulcer or amputation. Participants use the mat daily, and a remote team monitors the data to catch early signs of tro…

This study tests if a faster MRI scan, combined with a blood test, can find liver cancer earlier than the standard ultrasound in people with cirrhosis. The goal is to catch cancer at an early, more treatable stage and reduce deaths from liver cancer. About 4,700 veterans with cir…

This study looks at whether metformin, a medicine used for diabetes, can lower the risk of death, heart attacks, or strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will be followed over time. The goal is to see if…

This study tests a drug called CORT108297, which blocks the stress hormone cortisol, as a short-term treatment for PTSD in veterans. Forty veterans with PTSD will take either the drug or a placebo daily for one week. The goal is to see if it reduces PTSD symptoms and to check its…

This early-stage trial is testing whether stem cells taken from a patient's own bone marrow can reduce the long-term pain caused by chronic pancreatitis. Researchers will also check if the treatment improves pancreas function and quality of life. The study involves 40 adults with…

This study tests whether methylphenidate (Ritalin), a drug used for ADHD, can improve attention and memory in adults with epilepsy. 226 participants will be randomly assigned to take either the drug or a placebo for 8 weeks, then all can take the drug for another 8 weeks. The goa…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will randomly receive either tadalafil or a placebo pill for 6 months, and research…

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will enroll 190 veterans and provide 12 sessions of CBT designed for chronic pain. T…

This study tests a new clinical decision support tool that helps physical therapists tailor rehabilitation after total knee replacement. Instead of a one-size-fits-all approach, the tool uses each patient's recovery data to personalize therapy. The goal is to improve knee functio…

This early study tests a device called intermittent theta burst stimulation (iTBS), which uses magnetic pulses to activate brain cells. Researchers want to see if it can safely reduce impulsivity and suicidal thoughts in 55 veterans who have had a mild traumatic brain injury. The…

This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers wi…

This study tests whether a dietary supplement called MitoQ, combined with exercise rehabilitation, can improve blood vessel function in older Veterans (age 50+) who have Long-COVID. The goal is to speed up recovery and reduce long-term health problems. Researchers will measure ch…

Many blast-exposed veterans struggle to hear in noisy places even though their standard hearing tests are normal. This study tests whether a new fitting method called speech-based audiometry can make low-gain hearing aids more effective than the usual approach. Eighty veterans wi…

This study tests whether adding memory-support strategies to a standard PTSD therapy, called cognitive processing therapy (CPT), helps older veterans learn and remember the therapy content better. The goal is to improve treatment response, since many older adults struggle with me…

This study tests a home-based telerehabilitation program for 40 veterans who recently finished curative treatment for early-stage lung cancer. The program lets participants choose from breathing exercises, walking, resistance training, or mindfulness to target their specific symp…

This study tests a short behavioral therapy called T-SIB designed to help veterans reduce nonsuicidal self-injury (like cutting or burning) and improve how they function day-to-day. Researchers will enroll 40 veterans who have self-injured at least twice in the past month. Half w…

This VA study tests a 40-minute web-based program designed to teach veterans coping skills for suicidal thoughts. 180 veterans with recent suicidal ideation will be randomly assigned to the web program or standard care. Researchers will measure changes in suicidal thoughts and be…

This study tests whether a combination of flywheel resistance and aerobic exercise can reduce fatigue and improve muscle function in veterans with chronic kidney disease who are not yet on dialysis. Thirty participants will undergo exercise training, and researchers will measure …

This study tests three group psychological treatments—Cognitive-Behavioral Therapy, Emotional Awareness and Expression Therapy, and Mindfulness Meditation—delivered over video for chronic musculoskeletal pain in older U.S. military veterans (ages 60-95). Researchers aim to see wh…

This study tests whether giving oxytocin nasal spray before couples therapy can help veterans with PTSD feel better and improve their relationships. About 240 veterans and their partners will take part. Half get oxytocin, half get a placebo, and all receive eight sessions of brie…

This study tests whether adding a cream containing imipramine (an antidepressant) to standard photodynamic therapy (PDT) can improve treatment of actinic keratosis, a common pre-cancerous skin condition. About 48 US veterans with fair skin and many pre-cancers will receive PDT on…

This study tests a short, 3-session program called MERA (Manage Emotions to Reduce Aggression) for veterans with PTSD who struggle with impulsive aggression. The program teaches skills to manage emotions using cognitive-behavioral and acceptance-based techniques. Researchers will…

This study looks at whether high intensity interval training (HIIT) can reduce frailty and improve resilience in older veterans. Researchers will enroll 200 veterans aged 65 and older who are not severely frail. Participants will do supervised and home-based HIIT exercises. The g…

This study is for veterans with mild traumatic brain injury (mTBI) and PTSD. It tests a non-invasive device that stimulates the vagus nerve (nVNS) to see if it can improve memory and reduce PTSD symptoms. Participants will use the device twice daily and be monitored for changes i…

This study looks at whether a supervised exercise program can improve balance and mobility in older adults who have moderate narrowing of the carotid artery (50-69% blockage) but no stroke symptoms. About 50 participants will do aerobic and balance exercises to see if their walki…

This study tests whether a program of water-based exercise followed by memory training can help Veterans with long COVID symptoms like brain fog and fatigue. About 50 people will take part over 8 months. The goal is to see if the program is safe, doable, and helpful.

This study tests whether methylphenidate (a drug used for ADHD) can improve concentration, memory, and PTSD symptoms in veterans. About 70 veterans with PTSD and thinking complaints will take the drug or a placebo in alternating periods over 20 weeks. The goal is to see if this a…

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests a non-invasive method called sensory augmentation for people who have had a stroke at least 6 months ago and still have balance problems. Small vibrations are applied to the skin to enhance the body's natural sense of position, aiming to make standing steadier an…

This study tests a type of talk therapy called Exposure and Response Prevention (ERP) to see if it helps veterans with obsessive-compulsive disorder (OCD) function better at work, home, and socially. About 160 veterans with OCD, half of whom also have PTSD, will receive either ER…

This study tests whether a non-invasive device that gently stimulates the vagus nerve can reduce withdrawal symptoms, anxiety, and cravings in 80 veterans with moderate-to-severe alcohol use disorder. Participants will receive the stimulation and complete questionnaires and a bra…

This study looks at whether a program combining walking and Tai Chi, supported by technology, can improve physical function in veterans who have both COPD (a lung disease) and long-term muscle or bone pain. About 136 veterans aged 40 and older will take part. The goal is to see i…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via video calls at home, can improve social functioning and mood in Veterans recently hospitalized for heart disease. About 132 participants will receive either 12 therapy sessions or standard…

This study tests a new bandage called exciflex that delivers small electrical pulses to help heal chronic wounds in Veterans with diabetes or spinal cord injury. The bandage can stay on for up to seven days without being changed. Researchers will measure wound size, temperature, …

This study tests whether wearing bright light therapy glasses can reduce daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who still feel tired despite using their CPAP machine. Sixty participants will wear the glasses for four weeks of active trea…

This study tests a simple, non-surgical program for older veterans with lumbar spinal stenosis, a common cause of back and leg pain when walking or standing. The program includes using a modified rolling walker and changing sleep positions to relieve symptoms. Researchers will tr…

This study tests whether a small device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. 80 veterans will use the device at home twice a day for three months. Researchers will measure changes in brain activity, heart function, and PTSD symptoms com…

This study tests a therapy called Targeted Cognitive Training (TCT) for veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. The goal is to improve thinking skills and daily functioning by using EEG brain scans to identify who will benefit most. A…

This study tests whether goal-oriented cognitive training delivered via video calls can help veterans with mild to moderate traumatic brain injury (TBI) improve attention, planning, and daily functioning. 80 veterans with lasting cognitive difficulties will participate remotely. …

This study tests whether a single dose of intravenous ketamine can quickly improve depression in 80 veterans with Parkinson's disease. Depression is common in Parkinson's and hard to treat, but ketamine has shown promise for other types of depression. The researchers will also me…

This study tests whether hearing aids can improve daily hearing for veterans who have normal hearing tests but still struggle to understand speech in noisy places. About 142 veterans will either get hearing aids or standard communication advice. The goal is to see if the devices …

This pilot study is testing whether ketamine infusions, followed by a short behavioral intervention, can help veterans with chronic low back pain and depression. About 44 veterans will receive four ketamine infusions over two weeks, and some will also get a brief narrative therap…

This study compares two ways of delivering a combined attention and strategy training program to veterans with mild traumatic brain injury and PTSD. One group receives the training in person, the other via telehealth. The goal is to see if remote delivery works just as well for i…

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This study tests a home-based program for veterans aged 60+ with multiple chronic conditions and poor physical function. The program combines high-intensity exercise, education, and motivational coaching delivered via video calls. Researchers want to see if it improves strength a…

This study tests whether a powered prosthetic knee (Ossur Power Knee) helps people with above-knee amputations walk better than a standard microprocessor knee. Twenty adults aged 45-75 who have used a prosthetic leg for at least a year will try both knees for a month each. Resear…

This study tests a suicide prevention program called VA BIC for Veterans who recently received mental health care outside the VA system. The program includes a one-hour education session and follow-up support. Researchers will measure whether it reduces suicidal thoughts in 120 V…

This study tests whether a home-based, supervised group exercise program can help high-risk Veterans recover their fitness after COVID-19. 80 Veterans with conditions like high blood pressure or diabetes will do guided workouts from home. The goal is to improve heart and lung fun…

This study tests whether a special type of sleep therapy, adapted for trauma, can help women veterans with both insomnia and PTSD feel more ready to engage in PTSD treatment. About 100 women veterans will be randomly assigned to either the sleep therapy or a general education pro…

This pilot study tests a non-invasive device that stimulates the vagus nerve through the neck to improve walking and balance in veterans with Parkinson's disease. About 40 veterans who experience freezing of gait will use the device at home. The goal is to see if this approach ca…

This study is for people with spinal cord injury who also have depression. It tests a new method to dose a brain stimulation treatment called rTMS, which is already approved for depression but usually requires a thumb movement to set the dose. Since many with spinal cord injury h…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This study tests a short, skills-based program called PST-Concussion for Veterans who have had a mild traumatic brain injury (concussion) and also struggle with mental health symptoms like depression or PTSD. The program teaches practical problem-solving skills to help with daily…

This study tests whether a wearable robotic arm brace (MyoPro) combined with movement training can help people who had a stroke more than 6 months ago and have severe arm weakness. The brace reads muscle signals to assist arm movement. About 60 adults aged 18-89 will be randomly …

This study tests a new type of supervised exercise for people with peripheral artery disease (PAD), which causes leg pain when walking due to blocked arteries. Researchers want to see if using muscle oxygen levels to guide exercise is better than standard therapy. The study invol…

This study tests whether a gentle brain stimulation technique called tDCS, combined with cognitive training, can help veterans with obesity reduce impulsive behavior and lose weight. About 124 veterans will be randomly assigned to receive either real or fake stimulation during tr…

This study tests a simple, 3-session writing program to help sexual minority Veterans cope with stress related to their identity and reduce symptoms of depression and anxiety. About 85 Veterans who identify as gay, lesbian, bisexual, or queer and have significant depressive or an…

This study is testing whether using a weighted blanket at night can reduce chronic pain and improve sleep in veterans. Researchers will give 160 veterans either a light (3-pound) or heavy (15-pound) blanket to use at home for 6 weeks. The goal is to see if the heavier blanket pro…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a brief writing therapy can better reduce PTSD symptoms in veterans. About 98 veterans with PTSD will receive either real or fake rTMS along with the therapy. The goal is to see if the combi…

This study helps Veterans with long-term muscle or joint pain find ways to manage it without medication. Participants work with a coach to explore their personal values and goals, and see how non-drug approaches like exercise or relaxation might fit. The goal is to reduce how muc…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, and r…

This study looks at whether oxygen, finasteride, or acetazolamide can help reduce sleep apnea in adults aged 60 and older with mild to moderate sleep apnea. Researchers will measure breathing stability and sleep quality. The goal is to find new, effective treatments for elderly V…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

This study aims to develop and test a 12-week exercise program designed specifically for women veterans who have experienced sexual violence. The program is tailored to their needs and delivered virtually. Researchers will check if the program is feasible and acceptable, and expl…

This study tests whether dronabinol, a drug related to cannabis, can help treat obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep tests before and after treatment will measure if breathing problems improve.

This study tests whether targeted practice in a driving simulator can improve driving skills for veteran stroke survivors. One hundred participants will each receive both active training (focusing on speed, lane position, collision avoidance, and dashboard attention) and a contro…

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. Researchers want to see if this approach is practical and helps veterans stay smoke-free for at least 3 months. About 50 veter…

This study tests a program called Contingency Management that gives Veterans rewards for quitting smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger trial…

This study tests a new way for people with Parkinson's disease to exercise at home using a special stationary bike that can be monitored and adjusted remotely. The goal is to improve movement and reduce symptoms without needing to travel to a clinic. About 72 veterans will partic…

This study compares a 3-session couples program (Brief Relationship Checkup) to standard individual care for 360 veterans and their partners who have relationship and mental health concerns. The goal is to see which approach better reduces suicide risk factors by improving relati…

This study is for Veterans who smoke and want to quit. Each Veteran picks a friend or family member to support them during the quitting process. Researchers will track whether this support helps Veterans use proven treatments like medication or counseling. The goal is to find bet…

This study tests if using mild electrical pulses inside the rectum can help people with spinal cord injury empty their bowels faster and easier. Currently, a finger is used to stretch the rectum, but electricity might work just as well. The study will compare the two methods in 1…

This study tests a mobile app designed to help veterans with PTSD who struggle with anger. 150 veterans will be randomly assigned to use either the anger-reduction app or a health education app. The goal is to see if the anger app helps more veterans get their anger under control…

This study looks at whether a special intermittent fasting diet can help people with advanced lung cancer who are already receiving immunotherapy. Researchers want to see if the diet is safe and doable for patients. The study will enroll 66 participants and track how many can com…

This study tests whether a drug called pimavanserin can improve sleep in veterans with post-traumatic stress disorder (PTSD) who also have insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. The goal is to see if it reduces insomnia severity and imp…

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both posttraumatic stress disorder (PTSD) and a substance use disorder. About 170 veterans will complete five writing sessions about their trauma. The goal is to see …

This study looks at whether walking on an incline is better than walking faster on flat ground for people with COPD. The goal is to find ways to improve exercise programs so patients feel less short of breath. About 54 veterans with COPD will take part, and researchers will measu…

This study looks at whether adding aerobic exercise (like walking or cycling) to standard physical therapy can help stroke survivors recover better. The goal is to improve arm movement, thinking, and mood. About 40 people who had a stroke at least 6 months ago will take part. Res…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 participants will take these medications and be tested on how well t…

This study compares two ways to deliver a home-based walking program for veterans with peripheral artery disease (PAD), a condition that causes leg pain while walking. Participants will either use a website, get telehealth support, or receive usual care. The goal is to see which …

This study tests a mobile app called MIST designed to help veterans reduce suicidal thoughts. The app uses techniques to change negative thinking patterns linked to suicide. About 50 veterans from one VA hospital will try the app alongside their usual care. The goal is to see if …

This study looks at whether giving Veterans who have trouble hearing a small personal amplifier in the emergency room can help them understand their discharge instructions better and lower their chances of coming back to the ER within 3 or 30 days. About 1,050 Veterans from six V…

This study tests a home-based exercise program for Veterans with peripheral artery disease (PAD), a condition that causes leg pain and limits walking. Instead of traveling to a facility, participants use a wearable activity monitor and join group coaching sessions through a mobil…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD. The training combines exercises to recognize emotions in faces and voices with attention training, since paying attention is key to understanding emotions in daily life…

This study looks at how to best offer cognitive behavioral therapy for chronic insomnia to older veterans at 20 VA clinics. About 20 veterans will take part to see if the therapy helps them sleep better and feel better. The goal is to find the best way to bring this effective tre…

This study looks at how to best offer group physical therapy to veterans with knee osteoarthritis. About 20 VA clinics will take part to see if this approach helps more patients start and stick with therapy. The goal is to make it easier for veterans to manage knee pain and stay …

This study compares a single therapy (Transdiagnostic Behavior Therapy) to separate treatments for social anxiety and PTSD in 264 veterans. The goal is to see if one therapy can effectively reduce symptoms and improve daily life. Participants will be assessed before, during, and …

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with moderate to severe anxiety and depression. About 84 veterans will take pregnenolone or a placebo for several weeks. The goal is to see if it helps with mood, sleep, pain,…

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury and chronic pain. Ten veterans will test the program, which will be adapted to their needs. The goal is to see if VR is a practical and acceptable way to deliver mindf…

This study looks at whether a smartphone app called PE Coach can help veterans with PTSD do better in a proven type of talk therapy called prolonged exposure. About 124 veterans will be randomly assigned to receive therapy with or without the app. The goal is to see if the app im…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device is designed to improve sleep quality by interrupting nightmares. Researchers also want to see if better sleep leads to improved cardiovascular health. …

This study tests four different programs to help cancer survivors who have been using opioids for a long time reduce their opioid use while still managing chronic pain. The goal is to find which approach works best to lower opioid doses without making pain worse. About 294 Vetera…

This study aims to find the most effective non-surgical treatments for chronic low back pain in Veterans. Over 2,500 participants will first try either continued care, an online pain self-management program, or enhanced physical therapy. Those who don't improve can then choose fr…

This study tests a new wheelchair design that lets users change gears, making it easier to push uphill, over carpet, or from a stop. Researchers will compare the multi-speed chair to a standard manual wheelchair in 30 adults with spinal cord injuries or diseases. The goal is to s…

This study tests whether cannabis compounds (THC, CBD, or both) can reduce chronic nerve pain better than a placebo in 320 Veterans. Participants will take the study drugs for 6 weeks, and researchers will measure pain levels and side effects. The goal is to provide clear evidenc…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study tests a new type of prosthetic foot that can change shape to fit different shoes, giving women veterans with below-knee amputations more footwear options. Researchers want to see if having more shoe choices improves body image and helps them take part in more social ac…

This study tests a strength training program using blood flow restriction (BFR) in people with advanced multiple sclerosis (MS) who need help walking or use a wheelchair. BFR uses a device that partially blocks blood flow to the exercising limb, allowing low-intensity exercise to…

This study looks at whether a daily supplement called glutamine can help veterans with Gulf War Illness who have ongoing stomach issues like pain, diarrhea, and bloating. Researchers will give 80 veterans either glutamine or a placebo for 12 weeks to see if it reduces symptoms an…

This study tests a mobile app that guides veterans through mental exercises to reduce phantom limb pain—pain felt where a leg used to be. About 36 veterans with a below-knee amputation will use the app at home with telehealth support. The goal is to see if the app is easy to use …

This study tests two treatments for insomnia in veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, and the other is a relaxation technique. Researchers want to see which one improves sleep and daily life more, and if benefits last over time. A…

This study looks at whether daily growth hormone shots for 6 months can improve quality of life in veterans who have both mild traumatic brain injury and adult growth hormone deficiency. About 172 veterans aged 21-55 will receive either the hormone or a placebo. The main goal is …

This study tests a 12-session workshop called STEP-Home-SP for veterans who left the military within the last three years. The workshop teaches skills to manage the transition, provides suicide prevention education, and helps connect veterans to VA healthcare. The goal is to redu…

This study tests a smartphone tool called the Virtual Hope Box Enhanced Facilitation (VHB-EF) to see if it lowers suicide risk in veterans after they leave a psychiatric hospital. About 928 veterans who recently had a suicidal crisis will use the tool, which provides coping resou…

This study compares two support programs for family and friends caring for Veterans with dementia after a hospital stay. One program, Hospital GamePlan4Care, offers a handbook, online training, and phone coaching tailored to the caregiver. The other provides general education and…

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy: a game-like reward system with social support, and health coaching. About 254 veterans will use a Fitbit and smartphone app to track their progress. The goal is to see if t…

This study is testing a web-based program called Calm Moms for pregnant veterans who have experienced trauma and are feeling anxious, stressed, or down. The program uses proven techniques to help manage these symptoms and is tailored to the unique concerns of pregnancy. About 36 …

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who lost a leg due to diabetes or artery disease will take part.

This study is testing a portable, wearable exoskeleton that helps stretch the legs and improve walking in people with spasticity caused by spinal cord injury. Ten veterans will wear the device during stretching, treadmill, and overground walking exercises. The goal is to see if t…

This study tests a new, non-invasive brain stimulation technique called LIP-tES neurofeedback to help reduce light sensitivity in Veterans who have had a mild traumatic brain injury. The goal is to see if the treatment is practical and well-liked by participants. Researchers will…

This study tests a personalized brain and spinal cord stimulation technique to strengthen hand muscles in people with ALS. Researchers will first tailor the stimulation for each participant, then compare two weeks of paired stimulation with or without hand exercises. The goal is …

This study compares a new adjustable prosthetic socket to a standard one in 40 veterans with below- or above-knee amputations. The goal is to see if the adjustable socket improves walking, comfort, and satisfaction. Participants will try both sockets so researchers can find which…

This study compares a new type of below-knee amputation (Ewing amputation) to the standard surgery in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the two surger…

This study looks at whether a 15-week lifestyle program combining weight loss and exercise can improve walking and daily life for obese veterans who had a stroke at least 6 months ago. About 99 veterans will take part. The goal is to see if this approach helps with physical movem…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This study is testing whether a lightweight, wearable exoskeleton can help people with Parkinson's disease walk better and reduce falls. Thirty veterans with mild to moderate Parkinson's will use the device during supervised walking sessions twice a week for eight weeks. Research…

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study tests a brief, two-session program for family members of Veterans with PTSD. The goal is to see if this family support helps Veterans stay in their regular PTSD therapy longer and have fewer symptoms. About 200 Veterans and their family members will take part. If it wo…

This study looks at why central sleep apnea happens and how to treat it better. Researchers will test a combination of a drug (acetazolamide), extra oxygen, and a breathing machine (PAP therapy) in 200 veterans with this condition. The goal is to understand the body's breathing c…

This study looks at whether a direct-to-patient teledermatology app and an artificial intelligence system can make it easier and faster for veterans to get skin care. Researchers will track wait times, travel distance, and satisfaction among over 63,000 new dermatology patients a…

This study is looking for biological clues to explain why some stroke survivors improve their walking with high-intensity interval training (HIIT) while others do not. Researchers will measure blood lactate, brain chemicals, and blood flow in 55 veterans with chronic stroke. The …

This study aims to help Veterans with substance use disorder by identifying what triggers their urges and substance use, such as anxiety or PTSD. Researchers will create a personalized model for each participant showing these links and test whether sharing this model with feedbac…

This study is creating and testing a program to help veterans with mental illness or substance use disorders adjust to life after prison. Researchers will work with 20 veterans who have been out of prison for up to three years. The goal is to develop tools that support a smoother…

This study is developing and testing a behavioral activation program for older veterans at risk of losing the ability to do daily tasks on their own. The program, delivered via video telehealth, helps veterans engage in activities that matter to them. The study will first adapt t…

This study looks at whether having both sleep apnea and COPD (called Overlap Syndrome) causes more thinking and memory problems in elderly veterans than having either condition alone. Researchers will test treatments like CPAP and extra oxygen to see if they improve brain functio…

This study tests a new care pathway to help primary care doctors at the VA better identify and treat non-alcoholic fatty liver disease (NAFLD) in Veterans. The program automatically flags at-risk patients and educates care teams. Researchers will compare this approach to usual ca…

This study is using a special X-ray technique (dynamic stereo X-ray) to see exactly how the bone and skin of a residual limb move inside a prosthetic socket. Researchers will compare two suspension methods—suction and elevated vacuum—in 21 people with below-knee amputations. The …

This study looks at two ways to introduce a mobile app called MyHealtheBladder to women veterans who have had urinary incontinence for at least three months. The app is designed to help manage bladder leakage. Researchers will compare how well each approach works in getting women…

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use non-invasive brain scans (fNIRS and EEG) to compare brain connectivity in SCS users and those being evaluated for SCS. The goal is to understan…

This study tests whether small electric currents applied to nerves can give upper limb amputees a sense of where their missing hand is in space. Researchers will try different stimulation placements to see which ones create these sensations. The goal is to use this feedback to he…

This study tests whether a helper (like a family member) can use a simple digital scanner to capture the shape of a veteran's leg for a new prosthetic socket. The goal is to see if this remote method works as well as the traditional in-person casting by a prosthetist. 25 veterans…

This study looks at a specific kind of tinnitus (ringing in the ears) that gets louder or softer when you move your head, neck, or jaw. Researchers want to better understand this condition and test a new way to treat it. About 72 adults with constant, bothersome tinnitus that cha…

This study reviews medical records from up to 400,000 U.S. Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. It also looks at RSV and flu patterns. The goal is to improve treatment strategies for respiratory viruses in the VA he…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study looks at whether a 3-month online nutrition program, including food delivery and cooking demonstrations, can improve diet and reduce loneliness in older veterans who have trouble walking. About 180 veterans aged 65 and older with slow walking speed or who use a walker …

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

This study is testing a new group program called Qnnections, designed to help LGBTQ+ veterans feel more connected to others and reduce suicidal thoughts. The program was created with input from veterans themselves. Researchers will work with 66 veterans to see if the program is p…

This study looks at how to better measure and treat a condition called neglect after a stroke, where people have trouble paying attention to one side of their body or space. Researchers will test a treatment that combines repetitive task practice with a mild brain stimulation tec…

This study aims to understand why many people with Long-COVID have trouble with walking and balance. Researchers will compare 136 veterans with and without Long-COVID by testing their thinking, vision, muscle strength, and movement. The goal is to create better ways to diagnose a…

This study compares two remote rehabilitation programs for Veterans who have had a mild to moderate traumatic brain injury (TBI) and struggle with attention, memory, or staying on track. About 120 Veterans will take part from home using digital apps. The goal is to see which appr…

This study tests a training program for VA doctors to improve how they care for Veterans with Long-COVID. The training focuses on listening to patients, building a shared understanding of the condition, and creating a personalized care plan. About 348 Veterans and their doctors w…

This study looks at why some veterans experience ongoing brain fog and other mental health issues after COVID-19. Researchers will track 200 veterans over time, using memory tests and blood samples to find clues. The goal is to better understand these symptoms and identify target…

This study looks at how different amounts and types of exercise can improve thinking and memory in Veterans aged 65 and older. Researchers will measure changes in cognitive skills and blood markers related to brain health. The goal is to understand which exercise habits work best…

This study is developing and testing a group therapy called Continuous Identity-Cognitive Therapy (CI-CT) for veterans who have recently experienced a suicidal crisis. The goal is to help them recover, regain hope, and build a positive sense of self and future. About 57 veterans …

This study tests whether a mild electrical current applied to the ear can help the brain learn and control hand movements. Researchers want to understand how this stimulation affects brain chemicals that support learning. The study involves 110 adults, including some who have had…

This study looks at how emotions and brain inflammation are connected to pain in veterans with fibromyalgia, a chronic pain condition. Researchers will measure mood, pain sensitivity, and markers of inflammation in 60 veterans. The goal is to use this information to create an exe…

This study looks at whether walking backwards can help Veterans who have had a stroke improve their walking and balance. About 48 participants will try either 18 or 27 sessions of backward walking training. Researchers will also use brain scans to see how the brain changes and to…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study looks at whether a genetic test can better identify which men ages 55-69 are at risk for serious prostate cancer and which are not. Current screening methods often lead to unnecessary biopsies. The goal is to see if using genetic information can help high-risk men get …

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study looks at how a moderate traumatic brain injury (TBI) from early or middle adulthood might speed up physical and mental decline in older age. Researchers will test balance and thinking in 70 Veterans aged 50-75 who had a TBI at least 15 years ago, even if they feel fine…

This study aims to create brain-based tools to identify which veterans with chronic psychosis are most likely to benefit from cognitive rehabilitation. Researchers will use EEG recordings to measure brain activity and see if these signals can predict improvements in thinking skil…

This study looks at how deep brain stimulation (DBS) in the subthalamic region affects the ability to align and focus both eyes on objects at different distances in people with Parkinson's disease. Researchers will use eye-tracking technology and brain models to find the best sti…

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study looks at whether a brief PTSD therapy called Written Exposure Therapy (WET) works for veterans who also have a serious mental illness like schizophrenia or bipolar disorder. About 48 veterans will try the therapy, and researchers will check if it's practical and liked …

This study looks at whether a brain scan can identify which stroke survivors with spatial neglect—a condition that makes it hard to notice or act on the left side—will benefit most from prism adaptation therapy. About 244 Veterans who had a right-brain stroke will be tested. The …

This study looks at whether mild traumatic brain injuries (mTBIs) in Veterans increase the risk of dementia. Researchers will measure memory, brain waves, brain structure, and certain proteins linked to brain injury and dementia. The goal is to better understand how mTBI may cont…

This study aims to help Veterans and their primary care doctors decide whether an in-person, phone, or video visit is best for each situation. Researchers will survey 600 Veterans and their doctors to understand what they value in each type of visit. Then, they will test a new te…

This study aims to understand why people with Parkinson's disease have balance problems and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes in 100 Veterans. The goal is to find brain pathways linked to balance issues so new…

This study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…

This study looks at whether older adults (75+) who had precancerous polyps removed in the past still benefit from repeat colonoscopies. Researchers will analyze health records from 130,000 Veterans and interview patients and doctors. The goal is to create clear guidelines on who …

This study looks at how to train therapists so they can better help veterans with PTSD. It compares different training methods to see which ones work best. About 240 mental health providers will take part over 9 months. The goal is to create a personalized training program that i…

This study tests whether a computer-based working memory training program can help veterans with PTSD learn to reduce fear responses. About 120 veterans will undergo memory training or a sham version, then have their brain activity and fear reactions measured. The goal is to see …

This study looks at how a single dose of nasal testosterone affects nerve and automatic body functions (like heart rate) in male veterans with spinal cord injury. Many men with spinal cord injury have low testosterone, which may worsen nerve problems. The study will test 15 men t…

This study aims to create and test a telehealth program to help veterans with psychogenic nonepileptic seizures (PNES) improve their thinking skills and daily functioning. About 47 veterans with PNES who report cognitive difficulties will give feedback to design a cognitive treat…

This study is testing a new type of prosthetic arm that uses an implanted wireless device to help people who have lost an arm or hand. The goal is to see if the device is safe and if it can improve how well the prosthetic works and feels. About 15 adults who have had an amputatio…

This study looks at a program where volunteers act as personal sponsors for veterans leaving the military. The goal is to ease their transition to civilian life, reduce stress, and prevent suicide. Researchers will track 630 veterans in Texas to see if the program helps them feel…

This study looks at 200 people with rheumatoid arthritis to understand why some have symptoms when lowering their steroid dose while others do not. Researchers will track inflammation, brain processing, and hormone levels to find patterns. The goal is to develop better, personali…

This study looks at whether a simple wearable device can reliably measure balance in veterans who have lost part of a leg. Better balance is linked to more physical activity and strength. The goal is to give doctors an easy, affordable tool to help improve mobility and quality of…

This study tests a new program that combines counseling and mobile phone tools to help homeless veterans with serious mental illness (like schizophrenia or severe mood disorders) better connect with their community. Fifty veterans will be randomly assigned to either the new progr…

This study tests whether smartphone location data can give early warning of mood episodes (mania or depression) and drops in social activity for 200 veterans with bipolar disorder. Participants use an app that tracks their phone's GPS, and researchers will build computer algorith…