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Scientists map Brain's reaching circuits after stroke

NCT ID NCT04286516

Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after stroke, not to provide treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 76 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria (control participants): * Be 45-90 years of age * Have adequate language and neurocognitive function to participate in training and testing * Be medically stable to participate in the study * Be English speaking Inclusion Criteria (participants with stroke): * Be 45-90 years of age * Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis * Stroke onset at least 6 months before enrollment * Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe) * Present with mild to moderate arm dysfunction * Be medically stable to participate in the study * Be English speaking Exclusion Criteria: (for both groups) * Unable to give informed consent * Have a serious complicating medical illness that would preclude participation * Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities * Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor * Unable to comply with requirements of the study * Enrollment in another greater-than-minimal risk study * Presence of medical condition or implant that prevents safe administration of TMS or MRI * Pregnancy

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Conditions

The condition(s) this trial relates to.

brain disorder cardiovascular disorder central nervous system disorder nervous system disorder stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain disease Cardiovascular diseases Central nervous system diseases Nervous system diseases Stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

    RECRUITING

    Pittsburgh, Pennsylvania, 15240, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.