ALCOHOL USE DISORDER

This phase 2 study tests whether mazdutide, a drug originally developed for diabetes, can help people with alcohol use disorder drink less. About 300 participants will receive either mazdutide or a placebo for up to 36 weeks. The study tracks drinking behaviors using a timeline f…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it w…

This study tests a behavioral program called contingency management for people who have had a liver transplant due to alcohol-related liver disease and have started drinking again. Participants are randomly assigned to either receive escalating gift card rewards for negative alco…

This study tests a single 75-minute counseling session called CAMI, which is a motivational interview adapted for Latino/a immigrants who drink heavily. Researchers will train community health workers to deliver CAMI at a primary care clinic and follow 220 participants for 12 mon…

This study tests a telehealth program called Ria for people with alcohol use disorder. Participants receive medication, coaching, educational videos, and a Bluetooth breathalyzer to track drinking. The goal is to see if this approach helps reduce heavy drinking more than simply w…

This study tests whether citicoline, an over-the-counter supplement, can reduce brain inflammation and improve thinking skills in teens and young adults (ages 16-22) who drink alcohol. Participants receive either citicoline or a placebo pill for a period, and researchers measure …

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The g…

This pilot study tests a web-based program called Let's Do Addiction Recovery Together! (LDART) for adults with alcohol use disorder. Participants use the website daily for a month to set recovery goals, watch motivational messages from people in recovery, and learn about local s…

This study compares two ways to treat alcohol use disorder in Black adults: a computer-based therapy offered in a Black church versus traditional care at a specialty clinic. Researchers want to see which setting gets more people to start and stay in treatment, and leads to more d…

This study tests whether a brain stimulation technique called deep rTMS can help people with alcohol use disorder drink less. Participants receive either real or sham rTMS over 3 weeks while staying in the hospital. Researchers measure changes in alcohol self-administration and c…

This early-phase study tests whether a type of brain stimulation called rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Participants receive 50 sessions of stimulation over one week. Researchers will measure changes in thi…

This study tests a program for couples to help adolescent girls and young women (ages 15-24) living with HIV in Uganda stay engaged in their HIV care. The approach works with male partners to reduce heavy drinking and intimate partner violence, which often interfere with women ta…

This study tests whether giving small monetary rewards for sober breathalyzer readings, collected remotely via a smartphone app, helps people with alcohol use disorder stay abstinent after completing detox. About 91 participants will use the app and breathalyzer at home, and rese…

This study tests whether combining online sessions with in-person therapy helps people with alcohol use disorder stay in treatment longer and drink less. About 1800 adults seeking public alcohol treatment in Denmark will take part. The goal is to see if this blended approach work…

This study tests a stepped alcohol treatment program delivered via telemedicine for 180 adults with chronic liver disease and unhealthy alcohol use. Participants are randomly assigned to either the treatment program (motivational interviewing sessions plus possible referral to ad…

This early-stage study tests whether a drug called apremilast can help people with Alcohol Use Disorder drink less alcohol. Ten adults will take the medicine and then have their drinking measured in a lab setting. The goal is to see if the drug reduces alcohol consumption, especi…

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Thirty participants who have HIV, smoke, and drink heavily will receive the medication along with counseling. The goal is to see if this approach is practic…

This study tests whether online mindfulness classes help people with alcohol use disorder stay in recovery longer than online support groups. About 470 adults who want to cut back or stop drinking will take part. The goal is to see if mindfulness helps with long-term recovery and…

This study tests new technology-driven programs to help people with alcohol use disorder manage their drinking and well-being. The programs focus on personal goals and healthy behaviors. Researchers will see if these virtual tools help people start and stick with treatment and re…

This study tests whether a smartphone app and breathalyzer can help people with alcohol use disorder stay sober by rewarding them for not drinking. Participants use the app to take breathalyzer tests remotely, and those who stay abstinent receive money. The goal is to make this e…

This small study tests whether psilocybin or ketamine, combined with talk therapy, can help men aged 25-65 reduce heavy drinking. Participants must have moderate to severe alcohol use disorder and at least 4 heavy drinking days per month. The study tracks alcohol use and brain ch…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This early study tests whether a drug called brexanolone is safe and feasible for people who have both PTSD and alcohol use disorder. The goal is to see if it can reduce stress-induced drinking. The study involves 25 adults aged 21-55 and focuses on safety and side effects.

This study tests a cognitive behavioral therapy (CBT) group designed specifically for women Veterans who have alcohol use disorder. About 162 women will take part, and the therapy focuses on changing drinking habits and related behaviors. The goal is to see if this female-only ap…

This study tests whether a 6-week phone-based therapy (Acceptance and Commitment Therapy) can help young adults aged 18-25 in Hong Kong who drink heavily. 60 participants will either receive the therapy or supportive calls. The main goal is to see if the approach is practical and…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both alcohol use disorder and PTSD. About 175 veterans will get either oxytocin or a placebo along with therapy. The goal is to see if oxytocin helps the…

This study tests whether taking a probiotic supplement for four weeks can help reduce alcohol cravings and improve thinking, mood, and gut health in people with alcohol use disorder. 38 participants are randomly assigned to receive either the probiotic or a placebo, and neither t…

This study tests whether a ketone supplement called Kenetik can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink during their 5-day inpatient treatment. The goal is to see i…

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This study observes 20 adults in Oregon who are receiving psilocybin services for alcohol use disorder. Researchers watch how their heavy drinking changes over time without interfering in their care. The goal is to learn whether this new model of care helps reduce drinking days.

This study uses a special PET/CT scan to measure inflammation in the brain and body of people with alcohol use disorder compared to healthy volunteers. Up to 90 participants will receive one scan with an investigational tracer. The goal is to understand how alcohol affects inflam…

This study tracks 10,000 hospital patients with low sodium levels (hyponatremia) to see how common it is, how fast doctors correct it, and what complications arise. Researchers will also look at rare brain damage from overly rapid correction. The goal is to improve treatment guid…

This study looks at how alcohol disrupts sleep in women versus men, and whether menstrual cycle phase plays a role. Healthy adults aged 21-45 who drink regularly will have their sleep monitored in a lab after receiving alcohol or a placebo. The goal is to understand if female sex…

This study follows 733 adults with alcohol use disorder to learn what helps them recover and what leads to relapse. Participants complete surveys and tasks about their drinking, emotions, and daily life over time. The goal is to find new ways to prevent relapse and support long-t…

This study looks at how alcohol changes brain activity when people interact with each other. Researchers will use special brain scans (EEG) on pairs of people while they drink and do tasks. The goal is to understand the brain processes behind alcohol's social effects. 240 adults …

This study follows 250 adults with Alcohol Use Disorder who receive 12 weeks of talk therapy. Researchers track their drinking habits, dependence severity, and quality of life for a year after treatment. The goal is to better understand the different ways people recover and what …

This study is testing a new assessment tool to understand how brain function relates to drinking behavior in people with alcohol use disorder. Researchers will have 1,400 adults complete computer surveys and tasks measuring thinking, decision-making, and emotions. The goal is to …

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study looks at whether a single dose of diclofenac, a common pain reliever, can change a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-blind fashion.…