ALCOHOL USE DISORDER

This study tests whether giving money for staying sober can help people with alcohol use disorder. Participants use a smartphone app and breathalyzer to prove they haven't been drinking. The goal is to make this effective treatment available to more people who need it.

This pilot study tests whether psilocybin (magic mushrooms) or ketamine, combined with talk therapy, can help men aged 25-65 with moderate to severe alcohol use disorder drink less. Twenty participants will receive one of the two treatments and be tracked for changes in drinking …

This study tests a culturally adapted version of motivational interviewing (CAMI) for Latino/a adults who drink heavily and may use drugs. The program includes discussions about immigration-related stress. Researchers will see if CAMI reduces heavy drinking days, drug use, and em…

This study looks at whether offering alcohol use disorder treatment in Black churches helps more people start and stay in treatment compared to traditional specialty clinics. About 137 Black adults with alcohol problems will be randomly assigned to either a church-based program o…

This study tests an experimental drug called mazdutide in 300 adults with alcohol use disorder. Participants receive either the drug or a placebo for several weeks to see if it reduces drinking behaviors. The goal is to find a new treatment option for people who struggle with alc…

This study tests an experimental drug called sunobinop to see if it can help people with moderate to severe alcohol use disorder drink less. About 200 adults who want treatment will receive either the drug or a placebo. The main goal is to see if the drug reduces the number of he…

This study tests new technology-driven programs to help people manage their alcohol use and well-being. The programs focus on setting goals and learning skills to improve health. Researchers want to see if these virtual strategies help people start and stick with treatment and re…

This study tests a behavioral program called contingency management for 30 liver transplant patients who have started drinking again. Half will receive rewards (up to $80 per week) for negative alcohol tests over 10 weeks, while the other half gets standard care. The goal is to s…

This early-phase study tests whether a non-invasive brain stimulation technique called accelerated rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. The goal is to see if the treatment can reduce heavy drinking and improve t…

This study tests whether giving small financial rewards for sober breathalyzer readings, collected remotely via a smartphone app, can help people with alcohol use disorder stay abstinent after detox. About 91 participants who recently completed detox will be monitored for several…

This study tests a telehealth program for people with alcohol use disorder. Participants either get the program right away or join a waitlist. The program includes medical checkups, medications, coaching, videos, and a breathalyzer. The goal is to see if it helps reduce heavy dri…

This study looks at whether a special ketone drink (Kenetik) can help reduce withdrawal symptoms in people with alcohol use disorder during a 5-day detox program. About 50 adults will receive either the ketone drink or a placebo, and researchers will track how much standard withd…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21–65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression sever…

This study tests whether taking a daily probiotic supplement for four weeks can help people with Alcohol Use Disorder reduce their alcohol cravings and improve thinking, mood, and gut health. Thirty-eight participants are randomly assigned to receive either the probiotic or a pla…

This pilot study tests whether a non-invasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury (mTBI) and/or post-traumatic stress disorder (PTSD). Twenty veter…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both PTSD and alcohol use disorder. About 175 veterans will get either oxytocin or a placebo before therapy sessions. Researchers will track changes in d…

This pilot study tests whether a 6-week telephone therapy program (Acceptance and Commitment Therapy) can help young adults in Hong Kong reduce their alcohol use. 60 participants aged 18-25 who drink at hazardous levels will be randomly assigned to either the therapy group or a s…

This early-stage study looks at whether a single dose of diclofenac, a common pain reliever, can alter a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-bli…

This study looks at different methods to help primary care clinics screen more adults for substance use problems. It involves 144 clinic staff from 48 practices. The methods include practice coaching, learning groups, and performance rewards. The goal is to see which approach wor…

This study follows 733 adults with alcohol use disorder to learn what helps people recover and what leads to relapse. Researchers measure thinking, social life, and drinking patterns over time. The goal is to find new ways to prevent relapse and support long-term recovery.

This study looks back at 10,000 hospital patients to understand how often low sodium levels occur, how they are treated, and what complications arise. Researchers will examine factors like how quickly sodium levels are corrected and whether that affects patient outcomes such as b…

This study uses a special PET/CT scan to look for inflammation in the brain and body of people with alcohol use disorder (AUD) compared to healthy volunteers. Up to 90 people (60 with AUD and 30 healthy) will receive one scan with an investigational tracer. The goal is to underst…

This study is testing a new assessment tool called the ANA to better understand how brain functions relate to alcohol use disorder (AUD). Researchers will have 1,400 adults complete computer surveys and tasks that measure thinking, decision-making, and emotions related to drinkin…