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Can magnetic pulses ease alcohol and brain injury struggles in veterans?

NCT ID NCT04043442

Disease control Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it with magnetic pulses over several sessions. The goal is to reduce disability and help veterans function better in everyday life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) device
What this could lead to
If successful, this could provide a new, non-invasive treatment option to improve daily functioning for veterans with both alcohol use disorder and mild traumatic brain injury.
What could go wrong
This is a Phase 2 trial with only 100 participants, so results may not apply to everyone. rTMS is generally safe but can cause headache or discomfort, and its long-term effectiveness for this specific group is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2019

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Can read and speak English * Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for AUD * Symptom Attribution and Classification (SACA) criteria (Pape, Herrold et al 2016, JHTR) for mTBI (without requirement of clinical neuropsychological impairment) Exclusion Criteria: * History of moderate to severe TBI * Neurodegenerative disease (e.g., Alzheimer's disease, Parkinson's disease, multiple sclerosis) * History of or current psychotic spectrum disorders (i.e., schizophrenia, schizoaffective and bipolar disorders) * Intellectual disability (WTAR predicted full-scale IQ score \< 70)42 * Are pregnant or nursing * Use of benzodiazepines, opiates, cocaine, or amphetamines in the past 30 days * Meet DSM-5 criteria for moderate to severe cannabis use disorder * Contraindications to MRI (e.g., claustrophobia, ferromagnetic metal in eyes or face, congestive heart failure, implanted cardiac pacemaker or defibrillator, cochlear implant, nerve stimulator) * Meet SACA criteria for 'Questionable Validity' of performance effort and symptom reporting

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Conditions

The condition(s) this trial relates to.

alcohol abuse Brain Concussion traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alcohol use disorder Mild traumatic brain injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Edward Hines Jr. VA Hospital, Hines, IL

    Hines, Illinois, 60141-3030, United States

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