Magic mushroom compound tested for dual depression and alcohol problems
NCT ID NCT04620759
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 36 times
Summary
This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with both major depression and alcohol use disorder. Researchers at Johns Hopkins will give 90 adults either psilocybin or a placebo and track changes in mood and drinking habits. The goal is to see if this psychedelic drug can reduce depressive symptoms and heavy drinking.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Johns Hopkins Center for Psychedelic and Consciousness Research
Baltimore, Maryland, 21224, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin
What this could lead to
If successful, this could point toward a new treatment option for people struggling with both depression and alcohol use disorder.
What could go wrong
This is a small, early-phase trial with only 90 participants. The results may not apply to everyone, and psilocybin can cause intense psychological effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.