Johns Hopkins University

This study tests if a 2-month combination of TB drugs works as well as the usual 4-6 month treatment for children under 10 with drug-susceptible TB. The shorter regimen aims to be easier for kids to complete and reduce side effects. About 860 children will take part to compare sa…

This study aims to find the best way to encourage more Latino adults and their friends to get the COVID-19 vaccine. Researchers will compare two methods: teaching people motivational interviewing skills versus simply providing vaccine information. The goal is to see which approac…

This study tests the RSV vaccine Arexvy in 170 adults with weakened immune systems to see if one or two doses work better. Participants will receive three vaccine doses over a year and be monitored for side effects and immune response. The goal is to find the best way to protect …

This study tests whether metformin, a common diabetes medication, can improve asthma control in overweight or obese adults whose asthma is not well-managed by their current inhalers. About 100 participants will take either metformin or a placebo for 24 weeks, with remote check-in…

This study tests a program called Full-SPARCS, where trained peers help people with HIV stay on their medication and in care after they leave prison in South Africa. About 400 participants will either get this support or standard care. The goal is to see if the program helps keep…

This study tests whether giving adults with obesity and food insecurity access to healthy groceries or vouchers, along with behavioral weight loss coaching, leads to greater weight loss than coaching alone. About 300 participants will be followed for a year. The goal is to see if…

This study is for adolescents and young adults living with HIV who are already on treatment but may struggle to keep the virus suppressed. It helps them choose the best treatment option, including a long-acting injectable, and provides support to access it. The goal is to help mo…

This study tests a program that combines home blood pressure monitors, a mobile app, community health workers, and pharmacist support to help adults with uncontrolled high blood pressure plus diabetes or kidney disease. About 425 participants from 16 clinics will either get usual…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help adults with obesity and binge-eating disorder reduce binge episodes and lose weight. About 105 participants will receive either tirzepatide, a placebo, or another drug (lisdexamfetamine), plu…

This study tests if the drug tesamorelin can help nerves regrow and muscles recover after a nerve injury in the arm. 36 adults with a cut ulnar nerve will either receive tesamorelin or no extra treatment after surgery. Researchers will check nerve function, muscle strength, and h…

This study tests whether sildenafil, a drug that relaxes blood vessels, can improve walking distance and heart function in 30 people with scleroderma who have mildly high blood pressure in their lungs. Participants will receive either sildenafil or a placebo for up to 12 months. …

This study tests whether a drug originally used for diabetes can slow brain and eye damage in people with multiple sclerosis (MS). About 120 adults with stable MS will receive either the study drug or a placebo for 96 weeks. The main goal is to see if the drug reduces brain shrin…

This study tests a brain implant that records and stimulates brain areas to help adults with paralysis control assistive devices like computers or wheelchairs and receive sensory feedback. The trial enrolls 5 people with conditions like spinal cord injury or ALS. The main goal is…

This study tests a new approach to hand and arm transplantation for people who have lost a hand or arm due to injury. The goal is to help the body accept the new limb while using much lower doses of anti-rejection drugs, which can cause serious side effects like infection and can…

This study tests whether a mobile app and text message reminders can help adolescents and young adults (ages 13-25) take their daily anti-rejection medication on time after a kidney or liver transplant. Participants use an electronic pillbox that tracks when they take their medic…

This study tests whether a 6-month program combining exercise training, problem-solving skills, and support from community health workers can improve fitness and health in 210 adults with type 2 diabetes, obesity, and early signs of heart trouble. Participants have low income and…

This study tests a program called PICU Up! that helps critically ill children start moving early in the ICU. The program combines gentle activity, better sedation management, and family involvement. Researchers want to see if it reduces time on breathing machines and improves rec…

This study tests whether a modified Atkins diet can control absence seizures in children aged 3-12 who have not yet tried any medication. For 3 months, one group follows the diet while another group takes standard seizure drugs. The goal is to see if the diet is a safe and effect…

This study compares group postpartum and well-child care to standard individual care for mothers and infants in Malawi. About 1,125 women and their babies will participate, with researchers tracking depression scores and vaccination rates. The goal is to see if group visits impro…

This study tests whether treating drug-resistant tuberculosis (TB) at local clinics by nurses works as well as treatment at hospitals by doctors. About 3,000 people in South Africa will take part. The goal is to make care easier to access and lower the financial burden on patient…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with cannabis use disorder reduce their cannabis use. Twelve adults will receive two psilocybin sessions with psychological support over 12 weeks, with follow-ups at 3 and 6…

This study looks at whether children aged 1 to 17 with well-controlled eczema can safely take less dupilumab or stop it altogether. About 30 kids who have been on the drug for at least a year will be randomly assigned to reduce their dose or stop. The goal is to see if they can m…

This study tests whether an 8-week or 24-week pulmonary rehabilitation program helps people recover lung function after tuberculosis (TB) treatment. 690 adults with confirmed TB will be randomly assigned to one of two rehab programs or standard care. The main goal is to see if re…

This study tests a device that electrically stimulates the balance nerve to help people with severe, long-term dizziness and unsteadiness. Researchers will implant the device in up to 8 adults aged 22-90 whose balance problems did not improve with standard therapy. The goal is to…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from Johns Hopkins HIV Clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and improve th…

This study follows people who have received a hand or arm transplant to see how they are doing over the long term. Researchers will measure hand function, pain, quality of life, and mental health. Participants must be at least 5 years post-transplant and agree to take immunosuppr…

This study tests whether providing healthy groceries and lifestyle coaching can help adults with high blood pressure and type 2 diabetes who live in areas with limited access to healthy food. About 80 participants from Baltimore will be randomly assigned to receive either standar…

This study looks at whether adding Dysport (a muscle-relaxing injection) to standard back bracing can slow or improve spine curvature in teens with scoliosis. About 90 adolescents aged 10-16 with mild to moderate curves will take part. Two-thirds will get the real injection plus …

This study tests whether combining video directly observed therapy (vDOT) with financial incentives helps more people complete treatment for latent tuberculosis. About 399 adults in Baltimore starting latent TB treatment will either receive usual care or the extra support. The go…

This study compares getting flap surgery within 72 hours of injury versus standard timing for people with severe open fractures or dislocations below the knee. About 356 adults will be randomly assigned to one of the two groups. The goal is to see if faster surgery reduces death,…

This study tests a device that electrically stimulates the balance nerve to help older adults (ages 65-90) who suffer from chronic imbalance, unsteady walking, and blurry vision due to inner-ear balance loss. The implant aims to improve stability and quality of life. Fifteen part…

This study tests whether providing tailored meals and fresh food to Black mothers who had gestational diabetes can help them lose weight after childbirth and prevent type 2 diabetes. About 40 low-income women will receive either prepared meals or a mix of meals and fresh grocerie…

This study follows 32 adults with severe balance disorders caused by inner ear damage, including from certain antibiotics. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve. Researchers will measure improvements in wa…

This study tests if people with atrial fibrillation (AFib) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with AFib and low-to-moderate stroke risk will be randomly assigned to either standard daily blood thinners …

This study tests whether switching from IV (intravenous) antibiotics to oral (pill) antibiotics early is just as safe and effective for treating Gram-negative bloodstream infections. Researchers will compare outcomes like recovery and side effects in 1,030 hospitalized adults. If…

This study tests whether wearing a custom-made external skull prosthetic can prevent Sunken Flap Syndrome—a condition where the brain sinks after a large piece of skull is removed to relieve pressure. About 72 adults who had this surgery will be offered the prosthetic. Researcher…

This early study tests a brain implant system that may allow people with tetraplegia (paralysis from the neck down) to control assistive devices like robotic arms using only their thoughts. The study involves 5 participants and focuses on safety and whether the implant can help t…

This study looks at the best time to give Hepatitis C (HCV) medication to people without HCV who receive a kidney from a donor with HCV. One group starts the medicine before transplant and takes it for 2 weeks; the other starts after transplant and takes it for 12 weeks. The goal…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past 2 years. The program teaches skills to manage stigma, improve communication, and connect with HIV care and safety resources. Researchers will check if t…

This study looks at whether a stepped-care digital health program can help adults with obesity maintain at least 5% weight loss for a year. Participants first lose weight through group counseling and meal replacements, then are randomly assigned to usual care, self-monitoring wit…

This study tests whether eating more omega-3s (found in fish and certain oils) can improve breathing and quality of life for people with COPD. Two hundred adults with moderate to severe COPD will receive either a special diet or their usual meals. Researchers will track changes i…

This study tests a drug called mirdametinib in adults with NF1 who have at least 24 skin tumors (cutaneous neurofibromas). The goal is to find a safe dose and see if the drug can shrink the tumors. The trial has two phases: first finding the right dose, then testing how well it w…

This study compares two approaches to help teenagers reduce alcohol use: brief counseling alone versus brief counseling plus a smartphone app that teaches mindfulness. About 1,500 teens aged 12-17 from pediatric primary care clinics will participate. Researchers will track drinki…

This study tests whether using a special walking analysis and custom shoe inserts can reduce the chance of new foot ulcers or amputations in people who have had a diabetic foot ulcer before. About 69 adults with healed foot ulcers will be followed to see if this approach lowers t…

This study is for people with a type of dementia that first affects language, called primary progressive aphasia. Researchers want to see if adding a mild electrical current to specific brain areas can make language therapy work better. The trial involves 60 adults aged 50-80 and…

This early-stage study tests if a drug called IMLYGIC, already used for certain skin cancers, can safely treat painful or disfiguring skin bumps (cutaneous neurofibromas) in adults with NF1. Ten participants will receive up to 4 cycles of injections directly into their tumors. Th…

This study tests a new way to help adults in Baltimore quit smoking. Participants will use a computer program with an avatar that gives advice on quitting, plus get support from a community health worker who can also help arrange lung cancer screening. The study will see if this …

This study looks at a surgery called FETO, done while the baby is still in the womb, to treat a severe birth defect where the diaphragm muscle has a hole. The goal is to see if FETO helps more babies survive after birth and have fewer health problems compared to standard care. Ab…

This study tests whether a simpler two-drug HIV regimen (dolutegravir/lamivudine) works as well as the standard three-drug regimen for people starting HIV treatment while also being treated for tuberculosis. About 150 participants will be randomly assigned to one of three treatme…

This study tests whether adding a patient's own concentrated bone marrow cells to a standard hip surgery (core decompression) can prevent the hip ball from collapsing and delay or avoid the need for a hip replacement. It enrolls 192 adults with early-stage osteonecrosis (bone dea…

This study compares two types of light used during bladder cancer surgery: standard white light and blue light, which makes cancer cells glow. The goal is to see if blue light helps surgeons remove more cancer and lowers the chance of the cancer coming back. About 200 adults with…

This early-stage trial tests whether giving two medicines—erythropoietin and melatonin—together is safe for very premature babies who have bleeding in the brain. About 60 infants will receive either the drug combo or a placebo, plus standard care. The goal is to see if this treat…

This study tests a program to help 800 adults in Africa control their high blood pressure. The program includes support for patients, healthcare providers, and the health system. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney disease.

This study tests a digital health program called Corrie Lipids in about 1,000 adults with high LDL cholesterol and elevated heart disease risk. Participants use a smartphone app, get clinician coaching, and have their care streamlined to help them reach cholesterol goals. The goa…

This study tests if omalizumab, an allergy drug, can reduce serious breathing flare-ups in people with COPD who also have allergies. About 334 adults over 40 who smoke or used to smoke will receive the drug or a placebo for 12 months. The goal is to see if the drug helps control …

This early-stage study tests if giving a newborn a dose of their parent's nasal bacteria can safely increase the variety of germs in the baby's nose. The goal is to see if this can help prevent dangerous infections like staph. The study involves 175 premature babies in the NICU a…

This study tests whether the drug Isturisa can improve health in people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers will measure changes in blood sugar, cholesterol, weight, bone density, and quality of life over…

This study tests a robot-assisted ultrasound biopsy to improve how doctors take tissue samples from the prostate. About 483 men with elevated PSA or abnormal exams will be enrolled. The goal is to see if the robot helps find more aggressive cancers and reduces missed diagnoses co…

This study is testing a simple, non-invasive method to detect early signs of Barrett's esophagus, esophageal cancer, and stomach cancer. Participants swallow a capsule attached to a string that collects cells from the esophagus and stomach. Researchers then analyze the DNA in tho…

This study tests whether a special camera with artificial intelligence can help screen more young people with diabetes for a condition called diabetic retinopathy, which can lead to vision loss. The study will include 500 children and teens with type 1, type 2, or cystic fibrosis…

This study tests a new robot called ProBot that helps doctors perform prostate biopsies with greater precision and less discomfort. The robot uses a special ultrasound probe and can be used for both standard and targeted biopsies. The trial will enroll 60 men aged 40 to 75 who ar…

This study looks at whether a new MRI contrast agent called Elucirem can detect scarring in the heart muscle as well as the standard agent Dotarem, but using a much lower dose. Researchers will compare images from 25 adults who previously had a heart MRI with Dotarem. If successf…

This study tests whether a new ultra-high resolution CT scan is better than a standard CT at finding blocked heart arteries. About 140 adults with suspected heart disease will get one scan, and the ultra-high resolution images will be compared to standard-quality images made from…

This study compares a 4-week course of the drug bedaquiline to standard longer treatments for preventing tuberculosis (TB) in people living with HIV and in close contacts of TB patients. About 2,530 participants will be followed for 72 weeks to see if the shorter regimen is as sa…

This study tests whether adding an oral medication (tacrolimus) before an ERCP procedure can prevent pancreatitis, a common complication. About 4,874 adults undergoing ERCP will be randomly assigned to receive either the standard rectal medication alone or that plus oral tacrolim…

This study looks at how a single dose of two F/TAF tablets (a common HIV prevention pill) works in the body over 14 days. It involves 24 healthy volunteers to measure drug levels inside cells. The goal is to see if a higher single dose could be used for HIV prevention.

This study tests a new way to prevent HIV among people who inject drugs and their friends. Researchers will train some participants to become peer educators, teaching their social network about HIV testing, PrEP (a daily pill that prevents HIV), and treatment for opioid use. The …

This study aims to make HIV and STI testing easier for men who have sex with men (MSM) in Baltimore by using a mobile van and online ads to reach them. Participants will either get help from a peer health navigator to connect to PrEP or HIV care, or just receive referrals. The go…

This study tests whether adding testing for common sexually transmitted infections (STIs) to standard risk screening helps more young women in Uganda start and stay on PrEP, a daily pill that prevents HIV. About 5,560 women aged 15-39 will be randomly assigned to either standard …

This study tests whether personalized, virtual music therapy sessions can boost memory and mood in people with mild Alzheimer's disease or mild cognitive impairment. Sixty participants will receive two 30-minute music sessions per week for 8 weeks. Researchers will measure change…

This study looks at 250 women who have had early-stage breast cancer and now struggle with both insomnia and being overweight. Researchers want to see if a special sleep therapy before a weight loss program helps them lose more weight than just learning about sleep. The goal is t…

This study looks at whether cannabidiol (CBD) can reduce stress and withdrawal symptoms in people who smoke cigarettes. About 90 smokers will take CBD and then be exposed to stress. Researchers will measure mood, pain, heart rate, and stress hormones to see if CBD helps. Some par…

This study tests a wellness program for adults with cystic fibrosis who struggle with fatigue and poor sleep. About 80 participants will either join the program or continue their usual care. The program includes coaching sessions and uses a fitness tracker to monitor activity and…

This study tests a special hearing program for older adults with Alzheimer's or related dementias who also have hearing loss. The goal is to see if addressing hearing loss can reduce troubling symptoms like agitation and confusion, and lessen the stress on caregivers. About 300 p…

This study tests if entering an MRI machine more slowly can reduce or prevent vertigo and dizziness. Researchers will have 100 people who are already scheduled for a 7 Tesla MRI enter at different speeds (1, 2, or 3 minutes instead of the usual 20 seconds) and report any spinning…

This study tests whether vestibular therapy—exercises for the inner ear balance system—can reduce falls in people with Alzheimer's disease. About 100 older adults with mild to moderate Alzheimer's and balance problems will receive either the therapy or a control activity. Researc…

This study tests whether trazodone, a medication used for sleep, can improve sleep quality and memory in people with early Alzheimer's disease and sleep problems. Researchers will compare trazodone to a placebo in 100 adults with mild cognitive impairment. The goal is to see if b…

This study looks at whether giving patients IV fluids at home for four weeks after bladder cancer surgery can lower the chance of being readmitted to the hospital. About 130 adults having their bladder removed for cancer will be randomly assigned to either standard care or standa…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. Forty adults will receive either psilocybin or a control drug, then complete surveys and pain tests over one mon…

This study compares two language therapies for people with aphasia (trouble speaking or understanding language) after a stroke. One therapy aims to stimulate the right side of the brain to improve storytelling and conversation, while the other focuses on word-finding. The trial i…

This study tests a trauma-informed digital program designed to improve health and safety for immigrant women who have experienced violence and have symptoms of PTSD or depression. Researchers will measure changes in stress, depression, PTSD, self-protection behaviors, and empower…

This early-phase study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The main goal is to see if depres…

This study tests a program called CAPABLE Transplant to help people with kidney failure who are waiting for a transplant. The program aims to solve problems like depression, physical weakness, or lack of support that keep them from being active on the waitlist. About 43 adults wi…

This study tests whether a mild electrical current applied to the back of the head (cerebellar tDCS) can improve language therapy for people with aphasia after a stroke. About 60 adults who had a stroke at least 6 months ago and have trouble naming objects will receive either rea…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who are not having surgery will be randomly assigned to standard care or standard care plus yoga…

This study tests whether a low-dose, slow-release form of the drug levetiracetam (AGB101) can reduce overactivity in a key memory region of the brain in healthy older adults. Over 60 participants aged 50–80 will receive both the drug and a placebo in random order for two weeks ea…

This study tests if a procedure called bilateral middle meningeal artery embolization is safe and possible for people with hard-to-treat chronic migraines. The procedure uses a plug-like material (Onyx) to block arteries in the scalp, which may reduce migraine-causing substances …

This study tests whether listening to a steady beat (like a metronome) can improve walking in people with Parkinson's disease who have a brain pacemaker (deep brain stimulation). Ten participants will walk with and without the beat, and with their brain pacemaker on and off. Rese…

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking abilities in people with early-stage behavioral variant frontotemporal dementia (bvFTD). About 50 participants will receive the drug for 12 weeks and undergo brain scans and memory tes…

This study looks at whether cannabidiol (CBD) can help reduce anxiety, mood problems, sleep issues, and agitation in adults with autism spectrum disorder. About 40 adults will take CBD pills for six weeks and a placebo for six weeks to compare effects. The goal is to see if CBD i…

This study tests whether the antidepressant escitalopram can make language therapy work better for people with aphasia (trouble speaking or understanding language) after a stroke. About 88 adults who had a stroke within the past 3 months will receive either escitalopram or a plac…

This study tests whether a mobile health program (mPATH) can improve memory and sleep in low-income older adults who are not very active and have trouble sleeping. About 176 participants will use a smartphone app to guide physical activity. The goal is to see if this approach hel…

This study looks at 200 cancer patients with fluid buildup around the lungs (malignant pleural effusion). It compares two ways to drain the fluid—using gravity or a vacuum bottle—to see which causes less chest pain. The goal is to find a method that improves comfort and quality o…

This study tests whether a low-dose epilepsy drug, AGB101, can reduce hallucinations and delusions in people with Parkinson's disease. About 30 adults will take the drug and a placebo at different times to compare effects. The trial lasts about 20 weeks and includes brain scans a…

This study looks at how women with bladder cancer cope with emotional distress and sexual health issues. Researchers will compare standard care to an educational support program. Participants complete surveys about mood and sexual function. The goal is to see if extra education a…

This study looks at a new way to treat shoulder pain that often happens after a stroke. The pain is thought to be caused by a buildup of a natural substance called hyaluronic acid in the muscles, making them stiff and painful. Researchers will give injections to reduce this build…

This study tests a 8-10 week program for caregivers with disabilities who care for a loved one. The program offers help finding resources, personal self-care planning, emergency and end-of-life planning, and support from peers. Researchers want to see if it lowers stress, burden,…

This study tests whether using smartphone-based personalized assessments can make cognitive-behavioral therapy (CBT) more effective for children with obsessive-compulsive disorder (OCD). About 30 youth aged 8-17 with moderate OCD will either receive standard CBT or CBT guided by …

This study tests if a special laser can safely improve the rough, bumpy skin caused by keratosis pilaris (KP), a common but harmless condition. Researchers will treat one arm of 25 adults and compare it to the untreated arm. The goal is to see if the laser reduces redness and mak…

This study compares Scrambler Therapy—a non-invasive device that sends mild electrical signals to the skin—to standard pain medications for people with ongoing pain after a stroke. Researchers want to see if the therapy can cut pain by at least half. The study will enroll 100 adu…

This study tests a self-administered rehabilitation tool that gently guides people to move their heads more to reduce motion sickness and improve balance. It is for adults with inner ear disorders, motion sickness, or who have had surgery for a vestibular schwannoma. Participants…

This study tests a digital toolkit (smartphone app) designed to help people with atrial fibrillation (AFib) learn about their condition, stick to treatments, and handle AFib episodes with less anxiety. Researchers will measure if the tool improves quality of life and reduces AFib…

This study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain how the brain perceives pain. Adults with chronic pancreatitis and persistent abdominal pain not helped by standard treatments will receive 5-10 sessions and be fol…

This study is testing whether a compound from cannabis called cannabidiol (CBD) can help people stop smoking tobacco. Researchers will give oral CBD to 50 adults who smoke at least 10 cigarettes daily and want to quit. The goal is to see if CBD increases short-term tobacco abstin…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help ease depression and improve quality of life in people with ALS. About 24 adults with ALS and depressed mood will receive the therapy in a controlled setting. The goal is to see if this approac…

This study tests a special belt that vibrates to give feedback, helping people with balance problems walk more steadily. Researchers at Johns Hopkins will enroll 90 adults aged 18-80 who have balance disorders, ataxia, or vestibular dysfunction. Participants will use the belt and…

This study looks at whether switching from ocrelizumab to ublituximab can reduce or delay the return of MS symptoms in 50 adults aged 18-65. Participants must have relapsing MS and have been on ocrelizumab for at least one year. The goal is to improve quality of life by easing fa…

This study tests a device called ScentCare, which delivers different scents to train the sense of smell in adults aged 60 and older who have lost or reduced smell. Participants will use the device twice daily for three months, while a comparison group does Sudoku puzzles. The goa…

This study compares two types of bladder removal surgery in 70 men with bladder cancer. One method spares the prostate capsule, the other spares nerves. The goal is to see which approach better preserves erectile function and urinary control after surgery. Participants will compl…

This study tests whether a natural hormone called pregnenolone can reverse the effects of being high on cannabis. Researchers will give 20 healthy adults who have used cannabis before either pregnenolone or a placebo, then measure their drug effects, thinking, and vital signs. Th…

This study tests whether online physical therapy sessions, tailored to each person's risk level, can reduce pain and disability in adults with chronic low back pain living in rural communities. About 434 participants will receive either personalized telerehabilitation or standard…

This study tests whether a gentle brain stimulation technique called tDCS, combined with computer-based thinking exercises, can improve memory and thinking in people who have had a mild stroke. About 60 adults who had a stroke within the past week will be randomly assigned to rec…

This study tests whether a pain management plan without opioids works just as well as one with opioids after a tubal sterilization procedure. About 120 women having minimally invasive surgery will be randomly assigned to one of two pain control approaches. The goal is to see if w…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS can improve language skills in people with primary progressive aphasia (PPA), a condition that slowly destroys the ability to speak and understand language. About 180 adults aged 50-90 with cert…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have persistent pain after a serious bone or muscle injury. Researchers want to see if it's practical to run a larger study later. About 30 adults will attend weekly th…

This study tests two short, proven therapies for young people ages 12-24 who are at risk for suicide and visiting emergency rooms. One approach helps youth create a safety plan and get follow-up calls, while the other teaches skills to handle relationship problems that can lead t…

This study tests whether a relaxation technique called progressive muscle relaxation (PMR) works better when combined with virtual reality (VR) for burn survivors. About 34 adults who have had a burn injury for at least 6 months and still have symptoms like pain, itch, or sleep p…

This study tests whether a mindfulness-based program can help adults with Tourette syndrome or persistent tic disorders reduce their tics. Participants will be randomly assigned to either mindfulness training or a relaxation and support group. The goal is to see which approach be…

This study tests if wearing special tape over the mouth at night can reduce snoring and improve sleep for people with mild sleep apnea. Researchers will have 100 adults and their bed partners try the tape at home and report on snoring, sleep quality, and how easy the tape is to u…

This early-stage study at Johns Hopkins University is testing whether psilocybin, a psychedelic compound, is safe for people who had a stroke at least one year ago. The study will enroll 20 adults and closely monitor their blood pressure and any psychiatric changes. The goal is t…

This study tests whether giving a single dose of methadone during laparoscopic or robotic hysterectomy can reduce the need for opioid painkillers after surgery. The goal is to lower the risk of opioid abuse and side effects. About 100 adults having a hysterectomy for non-cancer r…

This study tests a new mental health program for preschool children from low-income families. About 160 parents and their children from Head Start programs in Maryland will take part. The program offers virtual sessions to help parents manage their child's behavior and improve so…

This early-stage study tests whether giving both psilocybin and MDMA together is safe and can help reduce PTSD symptoms in 40 military veterans. Participants will be closely monitored for side effects and changes in PTSD severity. The goal is to gather initial safety data and see…

This study tests two types of talk therapy—cognitive behavioral therapy (CBT) and mindfulness-based therapy—to see which works better for treating insomnia and related depression in people who have had a mild to moderate traumatic brain injury (TBI) and also have post-traumatic s…

This study will compare physical therapy done through video visits (telerehabilitation) with in-person clinic visits for people with chronic low back pain. Researchers will enroll 1000 adults in Maryland and Utah who have had low back pain for at least 3 months. The goal is to se…

This study tests if scrambler therapy, a non-invasive nerve stimulation treatment, can reduce chronic pain in people with corticobasal syndrome (CBS). About 25 adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scrambler therapy or standard TE…

This study tests a new digital tool and communication training for doctors to improve conversations with parents about safe sleep for babies. About 350 parents and their infants will take part. The goal is to see if this approach leads to safer sleep practices and reduces the ris…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. 140 healt…

This study is testing a web-based app that helps people on the kidney or liver transplant waiting list share their story on social media to find a living donor. The goal is to see if this approach brings in more potential donors and leads to more transplants. The study involves 1…

This study uses a special eye scan (OCT angiography) to track changes in retinal blood vessel diseases like diabetic retinopathy and vein occlusion. Researchers will follow over 1,000 participants, including healthy volunteers, to see how imaging patterns relate to disease stage.…

This study looks at how your internal clock (chronotype) affects blood sugar control in overweight young adults aged 18-23. Researchers will compare what happens when meals and glucose tests are timed to match or mismatch your natural sleep-wake cycle. The goal is to understand i…

This study tests a program called Heart-to-Heart, where a community health worker helps heart patients with low income decide about joining cardiac rehab. About 50 adults from Johns Hopkins hospitals will take part. The goal is to see if the program is practical and if patients f…

This study is testing an AI-powered tool that helps emergency room doctors detect and manage acute kidney injury (AKI) earlier. Researchers will roll out the tool at three hospitals and track whether it improves care and outcomes for up to 200,000 adult patients. The goal is to s…

This study looks at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called ablation. Researchers want to see if more scarring means a higher chance of AF coming back or needing hospital care. …

This study looks at whether detailed heart scans (MRI) can better predict who is at risk for sudden cardiac death compared to the usual method of measuring heart pumping strength. Researchers will follow 400 people with weak hearts who are getting a defibrillator (ICD) to see if …

This study aims to find out if very small doses of psilocybin (the active ingredient in magic mushrooms) are safe for healthy adults to take at home. Twenty participants will receive increasing doses and a placebo on different days in a lab, with close monitoring of blood pressur…

This study looks at how nicotine pouches affect both regular smokers and people who rarely use nicotine. Researchers will measure nicotine levels in the blood and ask participants how the pouches make them feel. The goal is to understand the potential risks and appeal of these pr…

This study will follow 4,000 adults aged 25-35 without severe lung disease for many years. Researchers will measure lung function and track changes over time to learn what keeps lungs healthy and how to spot early signs of chronic lung disease. Participants will not receive any t…

This study looks at how heart failure might cause changes in brain volume. Researchers will use MRI scans to measure brain structures in 100 adults with heart failure and compare them to people with normal heart function. The goal is to understand the connection between heart hea…

This study is creating a new tool to measure opioid cravings in people receiving treatment for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to develop a more accurate …

This study looks at how natural brain chemicals change across the menstrual cycle in women with PMDD, a severe form of PMS. Researchers will compare blood levels of certain hormones and brain receptors in 288 women with and without PMDD. They will also test how a low-dose antidep…

This study aims to create a lab test to measure resilience in people with opioid use disorder. Researchers will see if tasks that test thinking and emotional control match how people rate their own resilience. The study involves 125 adults who currently use opioids or are in trea…

This study looks at how using vaporized cannabis and drinking alcohol at the same time affects thinking, coordination, and driving skills. Healthy adults aged 21 and older will take part in seven sessions where they receive different combinations of cannabis and alcohol. The goal…

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes and how their bodies react. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and cannabis. They will measure cigarette cravings, hea…

This study aims to understand why the right side of the heart fails in people with heart failure and high blood pressure in the lungs. Researchers will look at heart muscle samples from 50 adults to find the best ways to diagnose and test new treatments for this condition. The go…

This study looks at how a brain area called the cerebellum helps with thinking, not just movement. Researchers will use mild brain stimulation and fMRI scans in 50 healthy adults to see if it changes brain activity during tasks that involve remembering sequences. The goal is to b…

This study looks at why some children become overweight or obese by examining their eating behaviors, brain activity, and genetic factors. Researchers will study 210 children aged 7-12 from a larger family study. The goal is to find early clues that could lead to better ways to p…

This study looks at how estrogen and hormonal birth control affect bone health in adolescent and young adult women with cystic fibrosis (CF). In one part, researchers observe bone changes over a year in women using different contraceptives. In another small part, a few women try …

This study creates a database of 400 children and young adults with eczema who are using or will start systemic (whole-body) treatments. Researchers will track how well these treatments work by reviewing medical records and patient surveys. The goal is to make it easier to recrui…

This study from Johns Hopkins University looks at how commercial kratom extract products affect people who use them regularly. Researchers will measure changes in mood, thinking, heart rate, and pupil size after taking the product. The goal is to better understand the drug's effe…

This study gives healthy volunteers psilocybin (the active compound in magic mushrooms) or a placebo, then uses brain scans and thinking tasks to see how the drug alters thoughts and brain patterns. About 30 adults aged 18-75 will participate. The goal is to understand the drug's…

This study explores whether skin can be changed from one type to another, specifically making normal skin more like the thick skin on palms and soles. Researchers will inject participants' own skin cells (fibroblasts) into small areas and later remove the skin for lab analysis. T…

This study tests two strategies for finding tuberculosis (TB) cases and linking people to preventive treatment in peri-urban Uganda. One approach screens people at health clinics, while the other sends mobile teams into neighborhoods thought to have the most undiagnosed TB. Resea…

This study tests whether a drink containing ketones can change how healthy people breathe. Twenty volunteers will be monitored in a sleep lab after taking the drink or a placebo. The goal is to see if ketones might one day help with conditions like sleep apnea or high-altitude br…

This early-stage lab study uses nasal cells from people with chronic sinusitis and nasal polyps to see how the drug mepolizumab affects inflammation and cell barrier health. The study is small (8 participants) and takes place in a lab, not in patients directly. It aims to underst…

This study follows 5,000 adults with pancreatic cysts to understand how these cysts grow and change over time. Researchers aim to create a better way to tell which cysts are harmless and which may turn into cancer. Participants provide medical records and test results over up to …

This study looks at how old, worn-out cells (senescent cells) might cause uterine fibroids. Researchers will analyze tissue samples from 150 women to map these cells and their signals. The goal is to better understand the disease, not to test a treatment.

This study looks at whether a special parenting program can help 4- and 5-year-olds from low-income families do better in kindergarten. About 840 children and their parents will take part. The program teaches parents ways to support their child's social and behavioral skills, wit…

This study will test all patients who come to two busy emergency rooms in Cape Town, South Africa for HIV. The goal is to find out how many people have HIV or are at high risk and could benefit from a daily pill that prevents HIV (called PrEP). Researchers will then connect those…

This study looks for chemical changes in the blood that may be linked to premenstrual dysphoric disorder (PMDD), a severe form of PMS. Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women—some with PMDD and some without. The goal i…

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes and their body's reactions. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. They will measure how many puff…

This study looks at 150 people who had a stroke to see if damage to the blood-brain barrier (the brain's protective shield) can predict who will have memory or thinking problems in the next 3 years. Participants will have their brain scanned and then take short phone tests every …

This study aims to find brain-based markers that can predict how well people with ADHD will respond to the medication methylphenidate. Thirty adults with ADHD will undergo brain scans and thinking tests after taking either the drug or a placebo. The goal is to better understand t…

This study is testing whether a program called CAPABLE can help homebound older adults who feel socially isolated or lonely. The program works with home-based primary care to improve daily function and quality of life. Researchers will enroll 450 participants from Johns Hopkins H…

This study watches 22 regular kratom users to see how their usual dose affects them right away and what happens when they stop taking it. Participants take their own kratom product once, then stay in a research unit for a few days while researchers measure withdrawal symptoms, th…

This study is testing a new imaging method called full-field optical coherence tomography (FFOCT) on small lung biopsy samples. The goal is to see if FFOCT can give the same information as the standard lab analysis, but faster. About 20 adults with lung cancer or sarcoidosis who …

This study aims to find out if certain psychoactive substances can produce experiences similar to classic psychedelics. Researchers will give up to 6 different drugs or a placebo to 50 healthy volunteers aged 25-55, and measure their subjective effects using questionnaires. The g…

This study looks at how different forms of cannabis edibles—chocolates, gummies, and drinks—affect thinking, coordination, and blood levels of THC. Healthy adults aged 21-55 will take part in nine sessions where they consume these products and then complete tests of memory, atten…

This study tests a program that sends educational videos and messages through a patient portal to older adults with mild cognitive impairment or dementia and their care partners. The goal is to help them discuss and reduce medications that may be harmful or unnecessary. About 100…

This study looks at how well a nerve stimulation device (Inspire) works for people with obstructive sleep apnea who cannot use a CPAP machine. Researchers will measure airway changes during a sleep endoscopy to find out who will benefit most. The goal is to improve success rates …

This study looks at how the immune system of adults over age 75 responds to the annual flu vaccine. Researchers want to know if a common virus called CMV affects how well the vaccine works. About 1,025 healthy or frail older adults will join, and they will receive the flu shot fo…

This study explores whether the standard BCG treatment for non-muscle invasive bladder cancer causes mood changes. About 42 participants will provide blood and urine samples and complete mood questionnaires and daily diaries. The goal is to understand the link between the body's …

This study follows 10,000 healthy adults for up to 20 years to find ways to detect cancer earlier. Participants give blood samples and answer questionnaires about lifestyle and medications. The goal is to identify changes in proteins, RNA, and DNA that signal cancer before sympto…

This study is screening 9,000 people at high risk for pancreas cancer to find early warning signs. Participants include those with strong family history or certain genetic mutations. Researchers will analyze pancreatic juice and cyst fluid to detect cancer markers before the dise…

This study aims to document how TRPV4 neuropathy changes over 6 years in people with a confirmed TRPV4 gene mutation. Researchers will track symptoms, physical function, and disability through annual visits at Johns Hopkins. The study includes both adults and children (ages 3-80)…

This study looks at adults who survived acute respiratory failure (ARF) and the family members or friends who help them after they come home. Researchers want to see if what survivors and their caregivers expect from recovery is linked to their mental health. About 235 pairs will…

This study tests a program called Communities Care, which works to change harmful social norms that lead to violence against women and girls. About 3,500 adults and teens (ages 10 and older) in Somalia will take part. Researchers will measure changes in experiences of violence, b…

This study looks at whether aspirin can help people with COPD by reducing inflammation caused by overactive blood cells called platelets. Researchers will test two different aspirin doses in 48 former smokers with COPD to see which one works better. The goal is to find the right …

This study tests a new device that continuously measures pressure in the leg to detect a dangerous condition called compartment syndrome in patients on ECMO. Because these patients are sedated and can't report symptoms, early detection is hard. The study compares three methods to…

This study uses special MRI scans to measure the heart's energy levels without needles or tissue samples. Researchers want to see if heart failure is linked to lower energy production in the heart muscle. The study includes healthy volunteers and people with different heart condi…

This study looks at whether older adults (60+) with HIV have more trouble exercising due to how their leg muscles use energy. Researchers will compare people with and without HIV using MRI scans and walking tests. The goal is to understand the link between HIV, muscle metabolism,…

This early-phase study tests whether transferring a parent's nasal bacteria to a child can restore the child's nasal microbiome diversity after they've been treated with antibiotics for staph bacteria. About 175 children under 18 who have completed staph treatment will receive th…

This study looks at 1000 healthy people aged 25 to 35 to understand how their body, environment, and overall lung health relate to lung structure and function. Participants will take simple breathing tests to measure air movement, lung size, and gas exchange. The goal is to learn…

This study looks at how COVID-19 infection and mRNA vaccines impact pregnant women, their newborns, and breastfeeding. Researchers will collect blood, placenta, and breast milk samples from 300 participants to understand immune responses and pregnancy outcomes. The goal is to fil…

This study follows 1,500 people with heart failure who already have an implantable defibrillator (ICD). The goal is to learn which patients are at highest risk of sudden cardiac death by looking at heart structure, electrical signals, genetics, and blood markers. This information…

This study looks at how a commercially available ketone drink, Ketone-IQ, affects sleep and breathing in 20 healthy adults. Participants will take two different doses of the drink before bed at home. They will measure their ketone levels and wear a headband to track sleep pattern…

This study looks at whether sending text messages to first-time fathers, recruited through social media, can help them feel more confident and engaged in caring for their baby and partner. About 180 dads-to-be across the U.S. will receive texts from pregnancy until two months aft…

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study looks at how the cerebellum, a part of the brain, influences alcohol cravings and the brain's reward system in people with alcohol use disorder (AUD). Researchers will compare 122 adults with AUD to healthy volunteers using brain scans and mild electrical stimulation. …

This study looks at why people with heart failure with preserved ejection fraction (HFpEF) have trouble exercising. Researchers will measure energy use in the heart and leg muscles using special scans. The goal is to understand the problem better, not to test a treatment. About 1…

This study is creating a database of health information from people with achondroplasia, a bone growth condition. Researchers will collect data from medical records of up to 1,500 patients across several U.S. hospitals. The goal is to better understand growth patterns, surgeries,…