Johns Hopkins University

This study tested evolocumab, a drug that lowers bad cholesterol, in 60 people who had a specific type of heart attack (NSTEMI). The goal was to see if adding this drug to standard care could reduce cholesterol and inflammation in the heart and blood vessels. Participants receive…

This pilot study tested whether keeping a patient's blood pressure within a specific range during surgery could reduce complications like confusion (delirium) and heart problems. The study involved 27 older adults having hip, knee, or lung surgery. Researchers compared this targe…

This study tested whether treating donated blood with a special technology (Mirasol) can prevent infections like malaria, HIV, and hepatitis from being passed to patients during a transfusion. About 2000 people who needed a blood transfusion took part. The researchers compared th…

This study tested whether giving children with pulmonary hypertension two oral medications (sildenafil and bosentan) right away works better than giving just one (sildenafil alone). The main goal was to see if the combination helped children breathe easier and be more active afte…

This study looked at the best way to give fresh produce to adults who are overweight or obese and have trouble getting enough healthy food. 48 participants were split into two groups: one got weekly vouchers to buy produce, and the other got free produce boxes delivered to their …

This study tested a mobile app-based cardiac rehab program for 259 adults who recently had a heart attack, stent, or heart surgery. The goal was to see if using the app improved walking ability, cholesterol, and overall heart health compared to standard in-person rehab. The progr…

This study tested whether remote hearing care (telehealth) works as well as in-person clinic visits for older adults who already use hearing aids. About 339 people aged 70-84 took part. Researchers measured how many hours a day they used their hearing aids and how satisfied they …

This study tested a 12-month healthy weight program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. The program paired them with a health coach who provided lifestyle counseling and support for weight management, diet, and physical activit…

This study tested a new program to help people living in public housing in Baltimore quit or reduce smoking. The program combined remote support from specialists, access to quit-smoking medicines, and on-site community leaders. 18 adult smokers who wanted to cut back or quit took…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants were fed different diets for 5-week periods. The main goal was to see if the DA…

This study tested whether a mobile health van, combined with a needle exchange program, could improve HIV prevention and treatment for people who inject drugs. 720 participants were enrolled. The van offered services like HIV testing, treatment, and prevention tools. The goal was…

This study tested a new computer simulation, called a 'virtual heart,' to help doctors find the best spots to ablate (burn) heart tissue causing dangerous rapid heartbeats (ventricular tachycardia) in people with prior heart attacks. Ten patients with implanted defibrillators wer…

This study tested a new material called acellular adipose tissue (AAT) to safely and effectively repair modest soft tissue defects (like dents or depressions) on the trunk. Fifteen adults received injections of AAT, and researchers measured how well the material stayed in place a…

This study tested if evolocumab, a drug that lowers cholesterol, could also reduce inflammation after a heart attack. 100 adults who had a recent heart attack received either evolocumab or a placebo. The main goal was to see how much LDL cholesterol dropped after about a month. R…

This study tested two strategies for treating hepatitis C in people who use drugs and are in an opioid treatment program. One group received fast treatment with a peer mentor who had been cured of HCV, while the other group got the usual referral to an offsite clinic. The goal wa…

This study tested a drug called vericiguat in 45 adults with metabolic syndrome (a cluster of conditions like high blood pressure, high blood sugar, and excess belly fat) and poor heart blood vessel function. The goal was to see if the drug could improve blood vessel health using…

This study looked at whether people with HIV can donate a kidney to others with HIV. Only 3 donors took part, and researchers tracked their safety and kidney health over time. The goal was to see if this could be a safe way to get more kidneys for HIV+ patients in need.

This study tested the drug everolimus in 8 adults with idiopathic subglottic stenosis, a condition where scarring narrows the airway. The goal was to see if the drug could reduce the need for repeat surgeries. Researchers measured breathing improvements and time between surgeries…

This study tested whether adding a personalized ablation approach called OPTIMA to the standard pulmonary vein isolation (PVI) procedure could improve outcomes for people with persistent atrial fibrillation (AF). About 67 adults with persistent AF were randomly assigned to receiv…

This study looked at whether adding small rewards to integrated care centers helps people who inject drugs and men who have sex with men in India stay on HIV treatment and achieve viral suppression. Over 2,300 HIV-positive adults took part. The goal was to see which approach work…

This study tested whether telehealth medication management could help adolescents and young adults with uncontrolled asthma take their daily inhaled steroids more consistently. Over 300 participants were randomly assigned to receive either standard care or telehealth coaching. Th…

This study tested a new computer program called C-Raven that uses a virtual counselor to help people quit smoking. The program was tested with 18 adults in two clinics at Johns Hopkins Hospital. Researchers wanted to see if people would use the program and if it helped them stop …

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study tested whether giving Black adults with high blood pressure free produce, personalized dietitian coaching, and resource referrals could help them eat a heart-healthy DASH diet. 80 participants were split into two groups to see if the program was practical and improved …

This study looked at new, fast HIV tests that give results during a single clinic visit. The goal was to see if these tests help more people get linked to HIV treatment or prevention right away. Over 200 adults at high risk for HIV in Baltimore took part. The results showed that …

This study looked at 477 adults with pancreatic cysts to find better ways to tell which cysts are harmless and which might turn into cancer. Researchers combined medical images, patient history, and lab tests on cyst fluid and blood. The goal is to create a more accurate tool to …

This study tested whether a special eye-tracking device (video-oculography, or VOG) can help emergency room doctors more accurately diagnose the cause of severe dizziness or vertigo. The goal was to quickly tell apart harmless inner-ear problems from dangerous conditions like str…

This study tested a radioactive tracer called 11C-PABA to see if it can help doctors find infections deep inside the body using PET scans. 13 healthy people and patients with infections, inflammation, or cancer took part. The goal was to see if this imaging method can tell infect…

This study tested two medications, roflumilast and azithromycin, to see which one works better at preventing hospitalizations or death in people with severe COPD and chronic bronchitis. Over 1,000 participants who had a recent COPD-related hospital stay took one of the two drugs …

This study tested a remote health coaching program for pregnant women with overweight or obesity. Over 500 women received phone coaching and used a web platform to track their health. The goal was to limit weight gain during pregnancy and prevent related problems like gestational…

This study tested a program called Wakȟáŋyeža (Little Holy One) with 124 Native American caregivers and their 2-to-5-year-old children on a Northern Plains reservation. The goal was to reduce trauma and stress in parents, improve parenting skills, and boost children's emotional h…

This study tested whether a registered nurse (RN) could help more women at risk for HIV learn about and start PrEP, a daily pill that prevents HIV. About 440 women from OB/GYN clinics took part. Some received standard care, while others also got counseling and PrEP prescriptions …

This study tested whether a fully-automated digital diabetes prevention program works as well as standard human coach-based programs. 368 adults with prediabetes and overweight took part. The goal was to see if the digital program could help people lose weight, increase physical …

This study tested whether a program for young couples could help prevent sexually transmitted infections (STIs) and HIV. Researchers enrolled 68 people aged 16-25 and their partners. The program added joint health education counseling to standard individual counseling. The goal w…

This study tested a simple change in how clinics prescribe TB prevention medicine to people with HIV. Instead of doctors having to choose to prescribe it, the new approach made TB prevention the automatic option unless the doctor decided to opt out. Over 50,000 adults in South Af…

This study tested a device called Gigstride in 44 adults who have trouble walking due to leg problems. The goal was to see if people liked using it and if it helped with walking speed, stability, and stair climbing. Participants used the device and answered questions about comfor…

This study looked at ways to help older adults become more active after a minimally invasive heart valve replacement called TAVR. Forty people who had the procedure were split into three groups: one received motivational coaching, another got coaching plus a home exercise program…

This study tested a program for caregivers of people with advanced heart failure. The program helped caregivers build on their strengths, find purpose, and set goals for a healthier lifestyle. Researchers wanted to see if it could improve caregivers' quality of life and reduce th…

This study tested different non-surgical treatments to reduce pain and improve daily function in 1,937 people with knee osteoarthritis. The goal was to find effective alternatives to opioids for long-term pain management. Results help doctors choose the best treatment for each pa…

This study tested whether suvorexant, a sleep medication, could help reduce drug use and cravings while improving sleep and stress in 20 adults being treated for both opioid and stimulant use disorders. Participants were already stable on methadone or buprenorphine. The study mea…

This study tested a program called MEMORI Corps, where trained volunteers aged 55+ spend time with people who have dementia, doing fun and meaningful activities together. The goal was to see if this companionship could reduce loneliness and improve quality of life for people with…

This study tested a hearing care program for older adults with dementia and hearing loss. Speech-language pathologists provided the care instead of audiologists. The goal was to see if this approach could reduce troubling symptoms like agitation and improve quality of life. 77 pe…

This study tested a new device called Incremental Velocity Error (IVE) to see if it improves dizziness and balance better than standard vestibular rehabilitation. 24 adults with mild traumatic brain injury or inner ear problems took part. The goal was to measure how well the eyes…

This study compared two endoscopic procedures to relieve stomach blockage caused by advanced cancer. 112 adults who could not eat or only drink liquids were randomly assigned to get either a new ultrasound-guided bypass or a standard stent. The goal was to see which approach bett…

This study tested a new type of knife used to make the first cut when placing a central venous catheter (a large IV in a neck or chest vein). Doctors rated how easy and safe the knife was to use, and researchers tracked problems like needing to re-cut or restart the procedure. Th…

This small pilot study tested whether bright light therapy can reduce sleep problems in people with multiple sclerosis (MS). 27 adults with MS and sleep issues used a bright light device. The goal was to see if the light improves sleep and daily function by helping regulate the b…

This study tested a personalized activity plan for 61 people with early-stage dementia. The goal was to see if meaningful activities could help maintain thinking skills, memory, and mood as the disease progresses. Researchers worked directly with participants to design activities…

This study tested whether a therapy delivered by phone and home visits could help people who survived respiratory failure in the ICU. The therapy combined treatment for depression with physical rehabilitation. 52 adults who had been on life support took part. The goal was to see …

This study tested a two-session computer program plus a community health worker to help hospitalized people with HIV quit smoking. 22 participants joined to see if the approach was practical and liked by patients. The goal was to boost readiness to quit and use of nicotine replac…

This study looked at whether a short sleep therapy program (BBTI) helps people with substance use disorders who live in a residential treatment center. About 83 participants wore sleep trackers, completed surveys, and did sleep diaries. The goal was to see if better sleep helps t…

This study looked at whether a sleep medication called suvorexant can improve sleep and reduce stress in people recovering from opioid use disorder. About 138 adults on medication-assisted treatment (like methadone or buprenorphine) took either suvorexant or a placebo for 8 weeks…

This study tested a program called DAPPER for African American women aged 50 and older who had pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study measured changes in pain intensity and d…

This study tested a small nerve-stimulating device called the Bridge to see if it can reduce opioid withdrawal symptoms. 46 adults with opioid use disorder stayed in a research unit for 2-3 weeks. Some used the active device, some used a sham device, and some took a standard with…

This study tested whether combining grocery delivery with health coaching helps adults with high blood pressure and limited food access eat a heart-healthy diet. 67 participants received an Instacart+ membership, weekly grocery lists, and coaching via text and video for 4 months.…

This study tested whether playing music helps children with glaucoma pay better attention during visual field exams. 38 children took part, and researchers measured how often they missed signals or got distracted. The goal was to see if music could make the test more reliable and…

This study tested whether dupilumab, an injectable drug, can improve symptoms of chronic sinusitis in people who do not have nasal polyps. 33 adults took part in a randomized, double-blind, placebo-controlled phase 2 trial. The main goal was to see if the drug reduces symptom sco…

This study tested a program called CAPABLE for older adults (65+) who had been in the hospital. It combined help with medications, strength and balance exercises, pain management, and home modifications. The goal was to see if these services could improve their ability to walk, b…

This study tested a program where a pharmacist works with people with dementia, their caregivers, and their doctor to review and safely stop medications that may no longer be helpful. The goal was to reduce the number of pills taken, making life simpler and safer. The study inclu…

This study tested a new way to help staff at mental health programs provide better care for heart health risks like diabetes, high blood pressure, and high cholesterol. 85 staff and people with serious mental illness took part. The goal was to see if the program improved how staf…

This study looked at whether a stroke unit designed for local needs in Zambia could improve care and survival for 300 adults with stroke. Researchers compared the care and outcomes of these patients to a similar group treated before the unit opened. The goal was to see if more ev…

This pilot study looked at how well the antibiotic azithromycin works alone during the first 14 days of treatment for Mycobacterium avium complex (MAC) lung disease. Ten adults with MAC lung disease took azithromycin daily, and researchers measured changes in bacteria levels in t…

This study followed 41 adults who had skull base surgery to see how their sense of smell and taste changed afterward. Researchers also tested whether a simple smell training program could help them recover faster. The goal was to better understand these side effects and find ways…

This study looked at 43 people with scleroderma or unexplained pulmonary hypertension to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures to measure heart function and changes over 6 months. The goal was …

This study looked at how aging changes certain enzymes (proteins) in the blood and colon. Researchers collected blood and colon tissue samples from 21 adults, both younger (18-50) and older (65-80). They also checked whether the HIV medications tenofovir and emtricitabine affect …

This study tested whether a computer-based virtual counselor, along with support from a community health worker, could help adults in public housing quit smoking and get screened for lung cancer. Five people aged 50 or older who smoked took part. The goal was to see if the progra…

This completed study tested if having a Diabetes Navigator (a personal guide) helps people with type 1 diabetes use advanced technology like continuous glucose monitors and insulin pumps more effectively. 148 participants were randomly assigned to get navigator support or standar…

This study tested whether a virtual group session for Spanish-speaking mothers of newborns could help them learn about postpartum depression and connect with support resources. 26 mothers participated in a single group session alongside their baby's regular checkup. The goal was …

This study looked at how Delta-8 THC affects mood, thinking, and body functions compared to Delta-9 THC and a placebo. 28 healthy adults took part, either inhaling or eating the substances. The goal was to understand the differences, not to treat any disease.

This pilot study tested whether a computer program featuring an avatar (a digital guide) could help adults in low-income housing in Baltimore quit smoking and connect them with lung cancer screening. Ten participants were enrolled and followed for 6 months. The main goal was to s…

This study looked at 27 postmenopausal women with frequent urinary tract infections (UTIs) to understand why vaginal estrogen therapy works for only about half of them. Researchers examined changes in vaginal and bladder bacteria and immune responses before and after treatment. T…

This study followed 300 pregnant women with and without mood disorder histories to uncover why some develop postpartum depression or psychosis. Researchers collected genetic, hormonal, and environmental data like sleep and stress to identify risk factors. The goal is to eventuall…

This study involved 13 transgender women to see how Truvada® (a daily pill to prevent HIV) interacts with feminizing hormones like estrogen. Participants took Truvada® alone and then with added hormones, and researchers measured drug levels in blood and tissues. The goal was to f…

Infantile spasms are a serious seizure type that can harm development if not treated quickly, but they are often mistaken for normal movements. This study trained a computer program to tell the difference by analyzing videos taken by parents of 61 infants. The goal was to create …

This pilot study tested whether a new program to prevent low blood sugar (hypoglycemia) is practical and well-liked by patients, doctors, and clinic staff. It involved 35 adults with diabetes who take medications that can cause low blood sugar. The goal was to gather feedback and…

This study looked at 3000 adults with pancreatic cysts to find better ways to tell which cysts might turn into cancer. Current tests are not always accurate, so researchers used imaging, fluid from the cyst, and genetic markers to improve detection. The goal was to develop and te…

This study tested 30 healthy adults to see how Delta-8-THC and Delta-9-THC affect driving skills. Participants took the drugs by vaping or eating, then drove in a simulator. The goal was to measure lane weaving and other signs of impairment to help guide safety rules and public e…

This study measured the pressure inside the chest of 37 adults with a collapsed lung (pneumothorax) before their chest tube was placed. The goal was to better understand how pressure changes, especially in a dangerous type called tension pneumothorax. Researchers tracked whether …

This study tested a new radioactive dye called 18F-FDS that lights up on PET scans where certain bacteria or fungi are growing. Researchers wanted to see if it could help find infections in the body. Sixteen people with known or suspected infections or cancer took part. The study…

This study used a special PET scan to track where the tuberculosis (TB) drug pretomanid goes in the body. Ten people with TB received a tiny radioactive version of the drug so researchers could see how much reaches infected areas in the lungs. The goal was to learn more about how…

This study explored whether hearing and vision loss are linked to delirium (sudden confusion) in hospital patients. Over 1,500 adults answered screening questions and had their hearing and vision tested. Researchers also tested if providing hearing devices and communication tips …

This study tested a program called SHARE that helps older adults with memory problems and their family caregivers talk to their doctors about healthcare wishes. About 248 patient-caregiver pairs took part across 9 primary care clinics. The goal was to see if the program improves …

This study followed 200 children and young adults who are overweight or have high blood pressure. Researchers collected health information from their medical records to learn how weight affects the heart over time. The goal is to better understand these risks, not to test a new t…

This study looked at how two types of poor sleep—waking up often or having broken sleep—change the way a painkiller works in the brain. Healthy adults aged 18-48 took part in sleep experiments and then received a study drug to measure pain relief and addiction risk. The goal was …

This study looked at how taking cannabis by mouth and drinking alcohol, alone or together, affects a person's thinking, balance, and driving. Sixty healthy adults aged 21 to 55 took part. Researchers measured things like attention, memory, and driving performance to understand th…

This study tested a web-based toolkit to help jails provide better care for pregnant people with opioid use disorder. Jail staff used the toolkit and gave feedback through surveys and interviews over 12 months. Pregnant individuals in custody also shared their experiences. The go…

This study tested a computer tool that helps doctors identify social needs—like trouble getting food or housing—in African American patients with chronic diseases such as diabetes or high blood pressure. The tool gave doctors a risk score and suggested referrals to community orga…

This study looked at how common prescription and over-the-counter medications affect mood and medication preference in 25 healthy adults. Participants rated their drug liking and value after taking the medication. The goal was to understand these effects, not to treat any disease…

This study looked at whether training staff in community mental health clinics can improve how they help patients quit smoking. Researchers worked with 91 clinic staff members to see if their knowledge and confidence in providing smoking cessation support increased. The goal was …

This study tested a program that helps people waiting for a liver transplant find a living donor. Participants, along with a chosen 'Live Donor Champion,' received education and training over 2-3 months. The goal was to see if this support increases the number of donor inquiries …

This study looked at how eating dinner early or late affects metabolism in healthy adults aged 18-30. Researchers timed meals based on each person's internal body clock. Participants ate either before or after their natural melatonin rise, and blood samples were taken to measure …

This study tested whether a special PET scan tracer is safe for people with long COVID. Six adults who had COVID-19 at least 6 months earlier, some with ongoing symptoms and some without, received the tracer and MRI scans. The goal was to see if the imaging could spot differences…

This study tested whether a new, thinner freezing probe (cryoprobe) works better than the usual forceps for taking lung tissue samples during a bronchoscopy. About 500 adults with lung disease took part. The main goal was to see which tool leads to a clear diagnosis more often, w…

This study tested a program where trained community health workers helped primary care clinics better identify and support Latinx teenagers at risk for suicide. The program included safety planning, parent education, and care coordination over 6-8 phone sessions. Researchers meas…

This study looked at what influences trust in primary care doctors. Over 1,100 adults completed surveys after reading short stories about doctor visits. The goal was to see if these stories could change how much people trust their doctor, which may help reduce unnecessary medical…

This study tested a program that helps people with end-stage kidney disease find a living kidney donor. Patients on the transplant waitlist were encouraged to bring family and friends to educational sessions. These 'champions' then helped spread the word about the patient's need …

This study looked at whether playing an immersive computer game that mixes physical movement with mental challenges can improve thinking, memory, and brain structure in adults aged 40 and older who had a traumatic brain injury (TBI) years ago. 23 participants completed the 12-wee…