Johns Hopkins University

This study tests whether injecting steroids into the narrowed part of the windpipe after a dilation procedure can delay the need for another surgery. It involves 226 adults with idiopathic subglottic stenosis, a rare condition where the airway narrows. The goal is to see if this …

This study tests whether daridorexant, a medication that blocks certain brain signals related to wakefulness, can reduce alcohol cravings and improve sleep in people with alcohol use disorder and sleep problems. About 150 adults with moderate to severe alcohol use disorder and po…

This study tests whether a natural sugar called GlcNAc can safely help control Crohn's disease in people with a specific genetic change. About 40 adults with Crohn's will take either GlcNAc or a placebo for several weeks, then switch. The goal is to see if GlcNAc reduces flare-up…

This study tests whether peer support specialists can help liver transplant recipients with a history of alcohol-related disease stay sober and keep up with medical care. About 95 participants who have been alcohol-free for 1-3 years will be assigned to work with a peer supporter…

This study tests a new way to help Black and Hispanic women control high blood pressure by bringing health services right into beauty salons. Hair stylists will be trained to check blood pressure, and participants will get home monitoring, coaching, and pharmacist support. The go…

This pilot study tests if deep brain stimulation (DBS) can help people with schizophrenia whose symptoms don't improve with medication. The device targets a brain area linked to hallucinations and delusions. Fifteen adults with treatment-resistant schizophrenia will receive DBS a…

This study tests whether a program led by community health volunteers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic lung diseases like asthma or COPD. The program focuses on reducing tobacco smoke and air pollution, preventing infections,…

This study tests a program called iTHRIVE for 100 Black and Hispanic adults with high blood pressure and related conditions like diabetes. Participants get access to healthy foods, personalized dietitian coaching, and a home blood pressure monitor. The goal is to see if these too…

This study looks at whether using a low sodium salt substitute is safe for adults with high blood pressure who are already on medication. About 607 people in Bangladesh will replace regular salt with the substitute and be monitored for changes in potassium levels and blood pressu…

This study tests whether emetine, an old drug, can help people with dengue fever avoid severe illness or death. About 600 adults aged 18-65 will take either a low or high dose of emetine or a placebo pill for 7 days. Researchers will track their health and virus levels for 28 day…

This study tests whether using an AI-powered stethoscope can help doctors in rural Bangladesh safely reduce antibiotic use in children with pneumonia-like symptoms. About 2,500 children will be randomly assigned to standard care or care guided by the AI stethoscope. The goal is t…

This study looks at whether a new finger-stick test for hepatitis C is acceptable to patients in the emergency department. About 200 adults who have tested positive for hepatitis C antibodies but don't know if they have an active infection will be randomly assigned to get either …

This study looks at whether telling adults with prediabetes about their personal risk for diabetes helps them take action to prevent it. About 120 participants will either have a 30-minute talk with a healthcare team member, get a message through their patient portal, or receive …

This study tests whether N-acetylcysteine (NAC), an antioxidant supplement, can reduce repetitive and self-injurious behaviors in people with Cornelia de Lange syndrome (CdLS). Ten participants aged 13-35 will receive either NAC or a placebo for 8 weeks, then switch to the other …

This study tests a non-invasive device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bones. About 70 children will receive the treatment, and researchers will measure changes in pain intensity and medication use. The goal is to impr…

This early study tests whether applying nitropaste (a cream that widens blood vessels) during high-risk leg surgeries can improve blood flow to the wound and reduce complications like infection or poor healing. Researchers will use a special camera (SPY imaging) to measure blood …

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. About 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care, …

This study tests whether a handheld robot that vibrates and talks can help older adults with mild memory problems sleep better. 100 participants will compare robot-guided meditation to standard audio-only meditation. The goal is to see if the robot's touch and rhythm make it easi…

This study looks at whether racism-related stress makes it harder for Black adults with insomnia to benefit from a common sleep therapy (CBTi). About 100 Black adults aged 18-65 with insomnia and depressive symptoms will use a digital CBTi program for 6 weeks. Researchers will tr…

This study tests a biofeedback breathing system called Freespira in 73 youth aged 9-17 with anxiety or panic disorders. Participants use the device to learn breathing techniques that may reduce symptoms. The goal is to see if it lowers anxiety scores on a standard child anxiety q…

This study tests a personalized brain stimulation method for 10 people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. The approach uses AI to tailor electrical stimulation to each person's unique brain signals, combined with c…

This study tests a new, personalized brain stimulation method for people with mild cognitive impairment (MCI). Using AI and real-time brain readings, the device customizes electrical pulses to target each person's specific memory-related brain areas. Ten participants will receive…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and mental flexibility in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personaliz…

This study tests whether combining semaglutide (a diabetes drug) with naltrexone (an addiction medication) is safe and helps reduce drinking in people with alcohol use disorder. About 45 adults enrolled in a 4-week inpatient program will take the combination and report any side e…

This early-stage study tests whether a shortened LSD experience, combined with the drug risperidone, is safe and effective for people with severe major depression. Ten adults with moderate to severe depression will receive LSD followed by risperidone 45 minutes later. The goal is…

This study tests whether a daily supplement called lithium orotate is safe and can reach the brain in people with early Alzheimer's. Forty adults will take either the supplement or a placebo for 9 weeks. Researchers will check for side effects, measure lithium levels in spinal fl…

This study tests a program called SPARK for adults aged 50 and older who have ongoing pain, depressive symptoms, and trouble moving around. Participants will receive 8 nurse visits at home to learn ways to cope with pain and improve mood. The goal is to see if this approach reduc…

This study tests whether simple changes to the bedroom environment and basic sleep tips can improve sleep in older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to make agreed-upon adjustmen…

This study looks at how blocking a certain serotonin receptor (5-HT1a) changes the effects of psilocybin, the active ingredient in magic mushrooms. Researchers will give 18 healthy adults psilocybin with or without a blocker drug and measure their experiences using surveys and br…

This study tests a mobile app called Health-E You/Salud iTu that teen boys use before a doctor's visit. The app helps them and their doctors talk about sexual and reproductive health. About 2752 males aged 13-21 who have had sex in the past year will take part. The goal is to see…

This study will test 70 healthy adults aged 21-55 to see how cannabis labeled as indica, sativa, or generic affects memory, driving ability, and feelings like sedation or stimulation. Participants will complete tasks and questionnaires after using each type. The goal is to unders…

This study tests if 3D printed splints made inside the hospital work as well as those ordered from outside companies. About 70 people having jaw surgery will take part. Researchers will compare cost, delivery time, and surgeon satisfaction between the two types of splints.

This study looks at how beta-myrcene, a compound found in cannabis, affects the body's response to THC. Researchers will give 32 healthy adults vaporized THC with or without beta-myrcene and measure drug effects and sleepiness. The goal is to understand how these compounds intera…

This study will test a new smartphone app called SOAR that uses artificial intelligence to analyze videos of laparoscopic surgeries. The goal is to give surgical trainees quick, detailed feedback on their technical skills and decision-making. About 100 participants, including sur…

This pilot study tests a new approach to help Black parents of preterm infants with chronic lung disease become more involved in their child's healthcare. Parents will fill out a short questionnaire before a doctor's visit to set goals for their baby. The study will see if this t…

This study looks at how the optic nerve responds to lower eye pressure in people who do not have glaucoma. Researchers will take pictures of the optic nerve before and after using a daily glaucoma eye drop for two weeks. The goal is to compare these results with those from glauco…

This study looks at how different doses of THC (the active ingredient in cannabis) affect eye movements and attention in people who use cannabis often versus rarely. Researchers will give 40 healthy adults either a placebo, a low dose, or a high dose of THC and test their eye con…

This study looks at whether a 50-minute education session is helpful for pregnant or new mothers being treated for opioid use disorder and a person who supports them. The session gives correct information about medications and newborn withdrawal. About 80 women and their support …

This study looks at whether a leaky blood-brain barrier and immune changes cause thinking and mood problems in people with ME/CFS (chronic fatigue syndrome). Researchers will compare people who got ME/CFS before the COVID-19 pandemic with those who developed it after. They will u…

This early-phase study tests a new radioactive tracer called [11C]CPPC for PET scans in 20 people with ALS and healthy volunteers. The goal is to see if the tracer can safely detect brain inflammation linked to ALS and track changes over time. This research aims to improve unders…

This study looks at whether a home-based exercise program (resistance training and stationary cycling) can protect or improve vision in people with glaucoma, a disease that damages eye nerves. Researchers will measure changes in vision, eye blood flow, and quality of life in 150 …