Johns Hopkins University

This study tests a procedure called FETO, where a tiny balloon is placed in the unborn baby's windpipe to block fluid and stretch the lungs, helping them grow. It is for pregnant women carrying a fetus with severe left congenital diaphragmatic hernia (CDH), a condition where the …

This study tests whether a smartphone app can help community health workers better support people with both TB and HIV in South Africa. The app helps track treatment, remind patients to take medicine, and catch problems early. The goal is to improve treatment success and reduce d…

This study looks at 22 adults with epilepsy who have been on a modified Atkins diet for at least a year and have high cholesterol. Researchers will test whether reducing saturated fat in the diet or taking a statin can safely lower cholesterol without affecting seizure control. T…

This study looks at the long-term safety of an antioxidant called N-Acetylcysteine (NAC) in 30 adults with retinitis pigmentosa, a disease that causes gradual vision loss and blindness. Participants take NAC tablets twice a day for up to 12 months. The goal is to see if NAC is sa…

This study looks at whether having a nurse case manager helps people with multi-drug resistant TB (MDR-TB) and HIV complete their long treatment. About 3,600 adults in South Africa are involved. Half of the clinics have a nurse case manager to guide patients, while the other half…

This study tests a program that combines trauma-informed care with a safety planning app for women living with HIV who have experienced intimate partner violence. The goal is to improve mental health, HIV management, and safety. About 450 women from a Johns Hopkins clinic will ta…

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can help adults born with a single ventricle who had Fontan surgery. The goal is to see if it lowers pressure in the veins and improves exercise ability. About 29 adults will take the drug daily f…

This study tests a less invasive surgery for unborn babies with spina bifida. Instead of opening the mother's belly and uterus, doctors use a tiny camera (fetoscope) to repair the baby's spine while still in the womb. The goal is to fix the defect and reduce brain pressure, while…

This study looks at whether using hearing aids over the long term can slow down memory loss and reduce the risk of dementia in older adults. It follows 629 people aged 70-84 who already took part in a previous hearing study. Researchers will compare those who got hearing help rig…

This phase 3 trial tests whether an oral antioxidant called N-acetylcysteine (NAC) can slow the loss of vision in people with retinitis pigmentosa, an inherited eye disease that causes night blindness and tunnel vision. About 485 adults aged 18 to 65 will take NAC or a placebo da…

This study tests whether adding fluid into the womb can help babies with missing or failed kidneys grow enough lungs to survive after birth. Pregnant women with this condition can choose to receive the fluid injections or just monitoring. Babies who survive will need lifelong kid…

This study aimed to see if a closed-loop spinal cord stimulator could reduce muscle stiffness (spasticity) and chronic pain in people who had a stroke or brain injury. It was designed for adults with moderate to severe symptoms. However, the study was withdrawn before any partici…

This early-stage study tests whether transferring a parent's healthy nasal bacteria to their newborn can help the baby resist Staph infections. The trial involves 34 infants in the NICU who are not yet colonized with Staph. Researchers will monitor the babies' nose bacteria over …

This study tests a program that combines home blood pressure monitoring with support from community health workers to help adults at risk for high blood pressure. About 600 adults with slightly elevated blood pressure will either get a home monitor and usual care, or the full pro…

This study compares two approaches for treating relapsing-remitting multiple sclerosis: starting with strong medications early versus beginning with milder drugs and switching if needed. Researchers want to see which strategy better prevents long-term disability. About 900 adults…

This study looks at three ways to improve HIV treatment for people who inject drugs in India: starting HIV medicine on the same day, getting care at community centers instead of government clinics, and offering extra support if the first treatment doesn't work. About 800 adults w…

This study looks at whether it is safe for people with HIV to receive a liver transplant from a donor who also had HIV. The main goal is to check for serious problems like organ failure, infections, or HIV complications. About 80 participants who already qualify for a liver trans…

This study tests a new drug called MW189 in 120 people who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling, which often causes further damage. Participants receive the drug within 24 hours of their stroke and…

This program provided HBOC-201, a blood substitute made from cow hemoglobin, to adults with life-threatening anemia who could not receive blood transfusions. The treatment aims to deliver oxygen to tissues when blood is not an option. Participants had very low hemoglobin levels a…

This study tests a program called PICU Up! that helps critically ill children in the intensive care unit start moving earlier. The program combines sleep support, delirium prevention, and less sedation to encourage safe mobility. Researchers will see if this approach reduces time…

This study was designed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment helps people with opioid use disorder stay off illicit opioids. Participants would have received either psilocybin or a very low dose, and researchers planned to …

This study looks at whether having a trained peer case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either usual care or extra support from a peer. T…

This study tests a new device called a multichannel vestibular implant for people who have lost most of their balance function due to inner ear damage. The implant electrically stimulates the balance nerve to help improve stability and vision during movement. Up to 30 adults with…

This study looks at whether psilocybin, a hallucinogenic drug, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression symptoms and drinking…

This study tests whether a brain shunt surgery helps people with idiopathic normal pressure hydrocephalus (iNPH), a condition that causes trouble walking and thinking. About 100 adults aged 60 and older will either get the real surgery or a placebo procedure. The main goal is to …

This study tests advanced ultrasound techniques to make breast images clearer, helping doctors spot microcalcifications, cysts, and tumors more accurately. About 252 women with certain breast findings will undergo standard and experimental ultrasound imaging. The goal is to impro…

This study tests whether adding home nurse visits and text message support to standard care helps young women (ages 13-25) with pelvic inflammatory disease avoid repeat sexually transmitted infections. Participants in Baltimore receive 30 days of nurse check-ins and health tips. …

This study looks at whether collecting sexual health information through electronic forms can help doctors identify women who could benefit from PrEP, a daily pill that prevents HIV. About 1,170 women ages 15-65 attending routine gynecologic visits took part. The goal is to see i…

This study looks at whether a program called ACTFAST can help prevent firearm injuries in people treated at trauma centers. About 1,776 adults admitted for injuries will take part. The program includes screening, brief advice, and referrals to promote safe firearm storage and red…

This study tests a training program called ACTFAST that helps doctors and nurses at three children's trauma centers talk to families about safe firearm storage. The goal is to prevent firearm injuries in kids by increasing counseling and safe storage practices. About 1,000 parent…

This study tests a new tool that helps doctors have better conversations with patients who have prediabetes. The tool uses a questionnaire to understand how ready a patient is to make healthy changes, then suggests resources like health coaches or diabetes prevention programs. Ab…

This study tests whether a high-intensity swallowing therapy program helps stroke survivors recover the ability to swallow safely. Researchers will enroll 60 adults who have trouble swallowing after an ischemic stroke. Participants will receive a standardized therapy protocol, an…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help adults with chronic PTSD who are already on antidepressants. Twenty participants will receive psilocybin therapy, with some also getting trauma-focused talk therapy. The goa…

This study gives 30 family child care providers and the parents they serve a smartphone app with self-care tips, parenting support, and early learning games for kids. A nurse helpline is also available. The goal is to see if this support lowers stress and improves child behavior.…

This study looks at whether a gentle brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake tDCS for 30 minutes over 10 sessions. The goal is to see if …

This study aims to see if a low-cost hearing device and training program, delivered in the community, can improve communication and quality of life for older Korean Americans (age 60+) with hearing loss. About 800 participants and their communication partners will be enrolled. Ha…

This study tests whether listening to musical patterns and receiving mild brain stimulation can improve arm and hand function in people with corticobasal syndrome, a rare brain disorder. Twenty participants will be split into two groups: one gets music therapy alone, the other ge…

This study aimed to compare two treatments for chronic low back pain caused by worn-out discs: injections of a person's own bone marrow stem cells versus standard steroid injections. It was designed for adults with long-term pain who had not improved with other treatments. Howeve…

This study tests a care program called COORDINATE for older adults (50+) with two or more chronic conditions who are leaving a special hospital unit. The program includes a nurse-guided needs assessment, goal-setting, and follow-up calls over 3 months. Researchers want to see if …

This study looks at whether using HEPA air purifiers at home can improve asthma symptoms in children, and if overweight kids benefit more. About 200 children with asthma from Baltimore, half overweight and half normal weight, will receive either real or fake air purifiers. The go…

This study tests if watching telenovela-style educational videos can lower anxiety and boost confidence in African-American and Hispanic family caregivers of hospice patients. 62 caregivers will either receive usual hospice care or add twice-weekly video sessions. The goal is to …

This study looks at whether giving fewer opioid pain pills after laparoscopic hysterectomy still keeps pain under control. About 120 adults having this surgery for non-cancer reasons will be randomly assigned to get either a standard or a reduced opioid prescription. The goal is …

This study tests a home-based digital literacy program for adults aged 65 and older. The goal is to help them better communicate with their healthcare team, manage their health information, and feel more socially connected. Twenty participants will learn to use digital tools in a…

This study tests whether a safe, painless brain stimulation technique called tDCS can boost memory and word learning in people with Alzheimer's disease. About 90 participants with either typical memory-loss Alzheimer's or a language-focused form will receive either real or fake s…

This study looks at whether tetracycline, an antibiotic, is tolerable and can reduce fatigue in people with Post-Treatment Lyme Disease (PTLD) — symptoms that persist after standard treatment. About 60 adults aged 18–80 will receive either tetracycline or a placebo for 3 months, …

This study tests whether taking a commercially available ketone drink (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use CPAP therapy. Participants will try two different doses and have their blood ketone levels and sleep…

This study tests whether an injection of hyaluronidase, a natural enzyme, can help reduce muscle stiffness and spasticity in the arm after a stroke. Fifty-six adults who had a stroke 4 months to 15 years ago will receive either the study drug or a placebo, and later switch to the…

This early-phase study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help reduce symptoms of obsessive-compulsive disorder (OCD). Thirty-five adults with OCD who have not responded well to standard treatments will receive psilocybin in a controlle…

This study tests whether a low dose of ketamine, given through an IV, can help reduce fatigue in people with multiple sclerosis (MS). About 110 adults with MS who experience significant fatigue will receive either ketamine or an active placebo. The main goal is to see if ketamine…

This study follows 80 people with Neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans and blood samples to track changes in nerve tumors. The goal is to find imaging …

This early-stage study tests whether a cream made from sulforaphane, a compound found in broccoli, can improve skin aging and protect against damage from ultraviolet (UV) and visible light. Twelve adults with healthy or moderately aged skin will have small skin samples taken befo…

This study aims to find new antibodies that may cause autoimmune gastrointestinal motility disorders, where the gut doesn't move food properly. Researchers will analyze blood samples from 300 people over age 13 with chronic gut symptoms. The goal is to better understand these con…

This study looks at how to best help people with serious mental illness take part in a heart disease risk reduction program called IDEAL Goals. Researchers will compare different support strategies, like coaching and extra help, to see which works best. About 72 staff and their c…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older already on a keto diet or starting the modified Atkins diet.…

This study looks at whether trained community health workers can help Korean American elders with dementia and their caregivers. About 288 pairs (elder and caregiver) will either get the program or usual care. The goal is to see if the program helps elders get medical care and im…

This study looks for early DNA changes in blood and tissue that might warn of esophageal cancer in people with Barrett's esophagus or chronic reflux. Researchers will follow 600 participants who are already having an upper endoscopy. The goal is to find markers that predict cance…

This study tests a program called CONNECT that helps women and Black/Latino adults learn about and join heart health research. About 1,000 adults with heart disease or risk factors like high blood pressure or diabetes will receive text messages with health info and study opportun…

This study looks at how often acid reflux (GERD) happens in people with obesity after they have a weight-loss procedure, either surgery or an endoscopic treatment. Researchers will track 250 adults over time to see who develops reflux symptoms, silent reflux, or related complicat…

This study looks at how listening to music that is personally meaningful, compared to standard playlists, changes the experience of psilocybin in healthy adults aged 21 to 75. One hundred participants will take a single dose of psilocybin and listen to different types of music wh…

This research study collects blood or skin samples from 100 adults with inherited heart rhythm problems (like Long QT Syndrome or Brugada Syndrome) and healthy volunteers. Scientists will turn these samples into stem cells that can become heart muscle cells in a lab. The goal is …

This study looks at how information from wearable devices (like activity trackers) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare data from 60 adults—some with HFpEF and some without—using devices, blood tests, a…

This study tests whether an educational program and a mobile health app can help adults with kidney failure find a living donor for a transplant. About 775 participants who haven't yet identified a donor will take part. The main goal is to see if more people receive a live donor …

This study was designed to test a new medical device called the Artemis Proximal Femoral Nail (PFN) for fixing a common type of hip fracture. The goal was to see if it is safe and works well compared to older devices. However, the study was withdrawn before any participants were …

This study tests three new pulse oximeters (devices that measure oxygen levels) in 936 children under 2 years old with pneumonia in Cape Town, South Africa. The goal is to see if these devices help healthcare workers correctly identify low oxygen levels and refer children for pro…

This study involves 95 cancer patients with fluid buildup around the lung (malignant pleural effusion) who have a tunneled pleural catheter. Researchers want to find out if a protein called TGF-B in the fluid can predict when the fluid stops coming back (pleurodesis), which would…

This pilot study looks at whether the type of anesthesia used during hip fracture surgery affects the risk of bone cement implantation syndrome (BCIS), a serious complication that can cause breathing problems, low blood pressure, and even cardiac arrest. Researchers will compare …

This study looks at the genes and environment of 2,500 people to understand what causes Crohn's disease and ulcerative colitis. It includes adults and children with IBD, their family members, and healthy volunteers for comparison. The goal is to find out why some people get IBD a…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) progresses over time. Researchers use non-invasive scans to measure liver fat and stiffness at the start and after one year. The goal is to fill major knowledge gaps, since people with HI…

This study looks at whether a computer-delivered alcohol intervention plus help from a community health worker can reduce heavy drinking and improve HIV prevention in women. About 12 women who drink heavily and are either living with HIV or at high risk will take part. The goal i…

This study aims to better understand inflammatory bowel disease (IBD) by collecting tissue samples from people with and without the condition. Researchers will analyze gene activity and other biological markers to uncover what causes IBD. Up to 1,100 participants aged 7 and older…

This study looks at whether a mobile health app can help living kidney donors complete their required follow-up visits after donating a kidney. About 400 donors will be randomly assigned to use the app or receive standard care. The goal is to see if the app improves compliance wi…

This study was designed to see how different drugs and drug combinations change mood, pain tolerance, and thinking skills in healthy adults aged 18 to 55. Researchers planned to measure how much of a drug people would take and how much they would pay for it. The study was withdra…

This study looks at Cleidocranial Dysplasia (CCD), a rare genetic condition affecting bones and teeth. Researchers want to understand how specific gene changes relate to symptoms and how the condition impacts daily life. About 300 people with CCD or their caregivers will complete…

This study tests a program to help doctors decide when to test for lung infections in critically ill children on breathing machines. The goal is to reduce unnecessary antibiotic use by avoiding tests that may lead to overtreatment. Researchers will track how well hospitals adopt …

This study looks at whether muscle twitching during a common neck pain treatment (radiofrequency ablation) can help predict if the treatment will be successful. Researchers will grade the twitching and compare it to pain relief results in 60 adults with chronic neck pain. The goa…

This study involves 150 people with relapsing-remitting multiple sclerosis (MS) and their doctors. The goal is to create a questionnaire that can confirm MS relapses without requiring an in-person visit, saving patients time and travel. Researchers will also test if better commun…

This study aims to reduce health gaps in Black and Latino communities by connecting people with health and social services. Researchers will track how many participants use these services and how satisfied they are. The goal is to build trust and improve health for those with dia…

This study looks at whether a comprehensive sexual education program in rural middle schools in Madagascar can reduce violence and bullying among students. About 4,500 students aged 10 and older, along with teachers, will be surveyed before and after the program. The goal is to s…

This study follows 500 people with neurofibromatosis type 1 (NF1) to see how their skin tumors (cutaneous neurofibromas) grow and change over five years. Researchers use 3D cameras to track tumors and study genetic links. The goal is to better understand these tumors to help doct…

This study looks at whether a patient navigator—a person who helps guide patients through the healthcare system—can improve timely follow-up after an abnormal breast imaging result. The study includes 196 people who had an abnormal screening mammogram and had not yet completed di…

This study follows 300 patients with severe alcoholic hepatitis who receive an early liver transplant (before 6 months of sobriety). Researchers track survival and whether patients return to drinking within a year. The study also surveys public opinion on this practice. It aims t…

This study collects blood and tumor tissue from 360 people with early-stage liver cancer who had surgery to remove their tumors. Researchers look for specific markers in these samples to better predict if the cancer will return and to guide future immune-based treatments. The goa…

This study tests whether a simple video can accurately measure vital signs like blood oxygen levels, heart rate, and blood pressure. Researchers at Johns Hopkins are recording 94 adults (ages 18-75) with both video and standard medical sensors to build a database. The goal is to …

This study creates a registry of 2,000 people with gastroesophageal reflux disease (GERD) and related conditions like Barrett's esophagus. Participants will be followed for up to 5 years to collect information from medical records and questionnaires. The goal is to better underst…

This study aims to find the genes and other factors that explain why some people with cystic fibrosis develop diabetes while others do not. Researchers will analyze DNA from 1,500 participants with cystic fibrosis and their parents. The goal is to better understand the causes of …

This study compares two ways of taking tissue samples from lung cancer patients to see which method provides better samples for genetic testing. About 349 adults with known or suspected non-small cell lung cancer will be randomly assigned to have a biopsy with or without a cytote…

This study looks at how well people with sarcoidosis take their prescribed medicines and whether taking them as directed leads to better health. Researchers will follow 150 adults with lung sarcoidosis for one year, tracking their medication use, lung function, and quality of lif…

This study was designed to test whether tartrazine, a common food dye, could temporarily make skin transparent in healthy volunteers. Researchers planned to apply different doses to the skin and take pictures to see if it improved visibility of structures beneath the skin. The st…

This study looks at whether giving families in rural Congo a youth-friendly economic program (raising rabbits) and a gender equality course for parents can improve mental health in teens aged 10-14. Over 3,000 adolescents and their parents from 30 villages took part. The goal is …

This study was designed to see if a new ultrasound device with a needle guide could help doctors insert needles into the femoral artery more safely and accurately. It was planned for adults with liver cancer who were already scheduled for a procedure called chemoembolization. How…

This study looks at whether placing a premature baby on their belly (prone) or back (supine) during delayed cord clamping helps them breathe better and reduces the need for a breathing tube. About 89 preterm infants will be observed for 30-60 seconds after birth. The goal is to f…

This study uses a huge database of over 5 million patients' cholesterol test results to better understand blood fat disorders. Researchers are looking at patterns and rare cases to improve future treatments. No new treatments are being tested; instead, the goal is to gather knowl…

This study aims to find genes that cause inflammatory bowel disease (IBD) specifically in African Americans. Researchers will collect health information and a blood sample from 2,400 African American volunteers, both with and without IBD. The goal is to better understand the gene…

This study looks at how getting older might change a person's ability to become aware of patterns in a simple learning task. Researchers used a mild electrical current to temporarily affect a part of the brain in 16 healthy adults aged 20-30. They then measured how well participa…

This study screens 1500 adults for oral HPV infection and related antibodies to identify those at higher risk for HPV-related throat cancer. Researchers follow participants over time to see which infections persist and what factors (like mouth bacteria or immune response) play a …

This study aimed to see if giving extra oxygen at night could improve blood sugar control in people living at high altitudes who have sleep breathing problems. It was designed for permanent residents of Puno, Peru, but was withdrawn before any participants were enrolled. The goal…

This study aims to find undiagnosed heart disease, diabetes, and obesity risks in adults living in urban Cameroon. Researchers will screen 200 volunteers over age 18 to see how many have these conditions without knowing it. The goal is to improve early detection and treatment in …

This study collects information from patients who undergo a procedure called percutaneous cholangiopancreatoscopy, where a thin scope is used to look at and treat bile duct issues like stones or blockages. Researchers will track how many patients can have their drainage tube remo…

This study planned to see if delivering medically tailored meals to Black women after pregnancy could help them control weight and blood pressure. It focused on women who had high blood pressure during pregnancy and were low-income. The study was withdrawn before any participants…

This study looks at whether MRI scans are safe for people with pacemakers or implanted defibrillators without the usual strict pre-screening. Researchers will enroll up to 4,500 participants who need an MRI for medical reasons. The goal is to see if current safety rules can be re…

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and TMS. The goal is to understand how p…