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Which anesthesia is safer for hip fracture surgery? new study aims to find out
NCT ID NCT06952257
First seen Jun 25, 2026 · Last updated Jul 22, 2026 · Updated 3 times
Summary
This pilot study at Johns Hopkins will enroll 24 older adults having hip fracture surgery with bone cement. It compares general anesthesia to epidural (neuraxial) anesthesia to see which one lowers the risk of bone cement implantation syndrome—a serious complication that can cause breathing problems, low blood pressure, or even cardiac arrest. The study also measures histamine and complement levels to understand why the syndrome happens.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- General anesthesia (intravenous) and neuraxial analgesia (epidural)
- What this could lead to
- If it works, this could point toward safer anesthesia choices to reduce serious complications during hip fracture surgery.
- What could go wrong
- This is a very small pilot study with only 24 participants, so results may not apply broadly. It is early-stage research, not a treatment trial.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 24 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients \>18 years old that are indicated for cemented hemiarthroplasty for hip fracture. Exclusion Criteria: * Patients with medical comorbidities that preclude randomization to an anesthetic regimen (e.g., severe aortic stenosis contraindicating general anesthesia or therapeutic anticoagulation contraindicating neuraxial anesthesia) or * a severe cognitive impairment that precludes the ability to provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Dept of Orthopadic Surgery, Johns Hopkins Hospital, JHOC 5221, 601 N. Caroline St.
Baltimore, Maryland, 21287, United States
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