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Brain zaps reveal secrets of aging and awareness

NCT ID NCT03655769

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses a mild brain stimulation technique called transcranial direct current stimulation (tDCS) to temporarily disrupt a brain region involved in learning. Researchers want to see if this disruption changes how aware people are of the connection between a tone and an air puff to the eye. The goal is to understand how aging affects this kind of learning awareness. The study involves 16 healthy adults aged 20-30 and uses fMRI to watch brain activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If successful, this could help scientists understand how awareness and learning change with age, potentially guiding future therapies for cognitive decline.
What could go wrong
This is a very small, early-stage study with only 16 participants. It is designed to measure brain activity, not to treat any condition, so direct health benefits are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 16 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2010

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Educational attainment of at least eight years and English as the native language * Mini-Mental State Examination (MMSE) score of 26 * Normal episodic memory (i.e., CERAD word List Recall \> 5) * Informed consent; 5) age of 20-30 Exclusion Criteria: * Disturbed consciousness * Other neurological or systemic disorder which can cause dementia or cognitive dysfunction * Prior history of a major psychiatric disorder * History of definite stroke * Focal lesion on MRI exam * Use of anxiolytic, antidepressant, neuroleptic, or sedative medication * Predominately left-handed * Has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Transcranial direct current stimulation

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