New study reveals how Hemp-Derived THC impairs driving
NCT ID NCT06218550
First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times
Summary
This study tested 30 healthy adults to see how Delta-8-THC and Delta-9-THC affect driving in a simulator. Participants took the drugs by vaping or eating, then performed driving and sobriety tests. The goal is to understand how Delta-8 impairs driving compared to Delta-9, helping guide safety rules and public education.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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30 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Be between the ages of 18 and 55 2. Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests 3. Test negative for recent cannabis use prior to each experimental test session 4. Test negative for drugs of abuse and alcohol prior to each experimental test session 5. Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission 6. Have a body mass index (BMI) in the range of 19 to 36 kg/m2 7. Report use of cannabis in the past 3 years (both sub-studies) and prior experience inhaling cannabis (either via smoking or vaporization) for vaporization sub-study participation 8. Have not donated blood in the prior 30 days. 9. Have a current government-issued driver's license Exclusion Criteria: 1. Non-medical use of psychoactive drugs other than nicotine, alcohol, or caffeine in the month prior to study participation. 2. History of or current evidence of health issues judged by the investigator to put the participant at greater risk of experiencing an adverse event due to drug exposure or completion of other study procedures. 3. Current concomitant medication use that may interact with the study drug (∆8-THC and ∆9-THC). 4. History of xerostomia (dry mouth), or the presence of mucositis, gum infection or bleeding, or other significant oral cavity disease or disorder that in the investigator's opinion may affect the collection of oral fluid samples. 5. Participation in other research projects that could impact the present study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins Behavioral Pharmacology Research Unit
Baltimore, Maryland, 21224, United States
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Other studies related to the condition(s) this trial covers.
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