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4,000 young adults join landmark lung health study

NCT ID NCT04543461

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will follow 4,000 adults aged 25-35 without severe lung disease over time. Researchers will measure lung function to learn what healthy lungs look like and find early warning signs of chronic lung disease. Participants do not receive any treatment—the goal is to gather knowledge to prevent future lung problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 4,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2021

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Young adults between 25 and 35 year of age at baseline

Ages

25 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1- Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation. 5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant Exclusion Criteria: 1. Severe asthma, which is defined as any of the following: 1. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = \>250 fluticasone, propionate =100 fluticasone furoate, \>200 beclomethasone, \>400 budesonide, \>220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS. OR 2. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR 3. One asthma hospitalization in the past 12 months 2. History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension 3. Current pregnancy 4. History of cancer other than non-melanoma skin cancer 5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease) 6. Inability to comply with study procedures, including 1. Inability or unwillingness to provide informed consent 2. Inability to perform study measurements 3. Inability to be contacted by phone (via calls and/or text messaging) or email 7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit). 8. Institutionalization

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Conditions

The condition(s) this trial relates to.

lung disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    30 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baylor College of Medicine

    RECRUITING

    Houston, Texas, 77030, United States

  • Brigham and Women's

    WITHDRAWN

    Boston, Massachusetts, 02115, United States

  • Columbia University

    NOT_YET_RECRUITING

    New York, New York, 10032, United States

  • Cornell University

    RECRUITING

    New York, New York, 10032, United States

  • Duke University

    RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Email: •••••@•••••

  • Johns Hopkins University

    RECRUITING

    Baltimore, Maryland, 21218, United States

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Mt. Sinai, NYC

    RECRUITING

    New York, New York, 10029, United States

  • National Jewish Health

    RECRUITING

    Denver, Colorado, 80206, United States

  • Nemours Children's Jacksonville

    RECRUITING

    Jacksonville, Florida, 32207, United States

    Contact Email: •••••@•••••

  • New York Medical College

    RECRUITING

    Hawthorne, New York, 10532, United States

  • New York University

    WITHDRAWN

    New York, New York, 10016, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Presbyterian Brooklyn Methodist Hospital

    NOT_YET_RECRUITING

    Brooklyn, New York, 11215, United States

  • Rush Universtiy

    RECRUITING

    Chicago, Illinois, 60612, United States

  • St. Vincent's Health System

    WITHDRAWN

    Indianapolis, Indiana, 46260, United States

  • Temple University

    RECRUITING

    Philadelphia, Pennsylvania, 19140, United States

  • University Of Alabama

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • University of Arizona-Tuscon

    RECRUITING

    Tucson, Arizona, 85724, United States

  • University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

  • University of Chicago

    WITHDRAWN

    Chicago, Illinois, 60637, United States

  • University of Colorado

    ACTIVE_NOT_RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Florida, Jacksonville

    RECRUITING

    Jacksonville, Florida, 32209, United States

  • University of Illinois at Chicago

    RECRUITING

    Chicago, Illinois, 60608, United States

  • University of Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Kansas

    RECRUITING

    Kansas City, Kansas, 66103, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of North Carolina Hospital

    ACTIVE_NOT_RECRUITING

    Chapel Hill, North Carolina, 27517, United States

  • University of Pittsburg-Emphysema/COPD Research Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Rochester

    RECRUITING

    Rochester, New York, 14642, United States

  • University of Vermont

    RECRUITING

    Colchester, Vermont, 05446, United States

  • University of Washington

    NOT_YET_RECRUITING

    Seattle, Washington, 98108, United States

  • University of Wisconsin Madison

    WITHDRAWN

    Madison, Wisconsin, 53792, United States

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37235, United States

  • Wake Forest School of Medicine

    RECRUITING

    Winston-Salem, North Carolina, 27104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.